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Thoracic Society of Australia and New Zealand (TSANZ) position statement on chronic suppurative lung disease and bronchiectasis in children, adolescents and adults in Australia and New Zealand.
Chang AB, Bell SC, Byrnes CA, Dawkins P, Holland AE, Kennedy E, King PT, Laird P, Mooney S, Morgan L, Parsons M, Poot B, Toombs M, Torzillo PJ, Grimwood K. Chang AB, et al. Among authors: grimwood k. Respirology. 2023 Apr;28(4):339-349. doi: 10.1111/resp.14479. Epub 2023 Mar 2. Respirology. 2023. PMID: 36863703 Free PMC article.
Eradicate Pseudomonas aeruginosa when newly detected in lower airway cultures. Individualize therapy for long-term antibiotics, inhaled corticosteroids, bronchodilators and mucoactive agents. ...
Eradicate Pseudomonas aeruginosa when newly detected in lower airway cultures. Individualize therapy for long-term antibiotics, inhal …
Human bocavirus-1 infections in Australian children aged < 2 years: a birth cohort study.
Saha S, Fozzard N, Lambert SB, Ware RS, Grimwood K. Saha S, et al. Among authors: grimwood k. Eur J Clin Microbiol Infect Dis. 2023 Jan;42(1):99-108. doi: 10.1007/s10096-022-04529-x. Epub 2022 Nov 25. Eur J Clin Microbiol Infect Dis. 2023. PMID: 36434280 Free PMC article.
Data were from the Observational Research in Childhood Infectious Diseases (ORChID) study, a Brisbane, Australia-based birth cohort of healthy, term, newborns followed prospectively for 2 years. ...
Data were from the Observational Research in Childhood Infectious Diseases (ORChID) study, a Brisbane, Australia-based birth cohort o …
Long-term Azithromycin in Children With Bronchiectasis Unrelated to Cystic Fibrosis: Treatment Effects Over Time.
Vicendese D, Yerkovich S, Grimwood K, Valery PC, Byrnes CA, Morris PS, Dharmage SC, Chang AB. Vicendese D, et al. Among authors: grimwood k. Chest. 2023 Jan;163(1):52-63. doi: 10.1016/j.chest.2022.08.2216. Epub 2022 Aug 27. Chest. 2023. PMID: 36030839 Clinical Trial.
BACKGROUND: Following evidence from randomized controlled trials, patients with bronchiectasis unrelated to cystic fibrosis receive long-term azithromycin to reduce acute respiratory exacerbations. However, the period when azithromycin is effective and which patients are l …
BACKGROUND: Following evidence from randomized controlled trials, patients with bronchiectasis unrelated to cystic fibrosis receive long- …
European Respiratory Society statement for defining respiratory exacerbations in children and adolescents with bronchiectasis for clinical trials.
Chang AB, Zacharasiewicz A, Goyal V, Boyd J, Alexopoulou E, Aliberti S, Bell L, Bush A, Claydon A, Constant C, Fortescue R, Hill AT, Karadag B, Powell Z, Wilson C, Grimwood K, Kantar A; other members of Child-BEAR-Net; Chalmers J, Collaro A, Douros K, Griese M, Grigg J, Hector A, Mazulov O, Midulla F, Möller A, Proesmans M, Yerkovich S. Chang AB, et al. Among authors: grimwood k. Eur Respir J. 2022 Nov 3;60(5):2200300. doi: 10.1183/13993003.00300-2022. Print 2022 Nov. Eur Respir J. 2022. PMID: 35728974
Respiratory exacerbations are associated with an impaired quality of life, poorer long-term clinical outcomes, and substantial costs to the family and health systems. ...
Respiratory exacerbations are associated with an impaired quality of life, poorer long-term clinical outcomes, and substantial costs …
Reducing exacerbations in children and adults with primary ciliary dyskinesia using erdosteine and/or azithromycin therapy (REPEAT trial): study protocol for a multicentre, double-blind, double-dummy, 2×2 partial factorial, randomised controlled trial.
Chang AB, Morgan LC, Duncan EL, Chatfield MD, Schultz A, Leo PJ, McCallum GB, McInerney-Leo AM, McPhail SM, Zhao Y, Kruljac C, Smith-Vaughan HC, Morris PS, Marchant JM, Yerkovich ST, Cook AL, Wurzel D, Versteegh L, O'Farrell H, McElrea MS, Fletcher S, D'Antoine H, Stroil-Salama E, Robinson PJ, Grimwood K. Chang AB, et al. Among authors: grimwood k. BMJ Open Respir Res. 2022 May;9(1):e001236. doi: 10.1136/bmjresp-2022-001236. BMJ Open Respir Res. 2022. PMID: 35534039 Free PMC article.
Our planned RCT seeks to address some of these unmet needs by employing a currently prescribed (but unapproved for long-term use in PCD) macrolide antibiotic (azithromycin) and a novel mucolytic agent (erdosteine). ...
Our planned RCT seeks to address some of these unmet needs by employing a currently prescribed (but unapproved for long-term use in P …
Extended Versus Standard Antibiotic Course Duration in Children <5 Years of Age Hospitalized With Community-acquired Pneumonia in High-risk Settings: Four-week Outcomes of a Multicenter, Double-blind, Parallel, Superiority Randomized Controlled Trial.
McCallum GB, Fong SM, Grimwood K, Nathan AM, Byrnes CA, Ooi MH, Nachiappan N, Saari N, Morris PS, Yeo TW, Ware RS, Elogius BW, Oguoma VM, Yerkovich ST, de Bruyne J, Lawrence KA, Lee B, Upham JW, Torzillo PJ, Chang AB. McCallum GB, et al. Among authors: grimwood k. Pediatr Infect Dis J. 2022 Jul 1;41(7):549-555. doi: 10.1097/INF.0000000000003558. Epub 2022 Jun 7. Pediatr Infect Dis J. 2022. PMID: 35476706 Clinical Trial.
Additional research will identify if an extended course provides longer-term benefits....
Additional research will identify if an extended course provides longer-term benefits....
Study Protocol for Preventing Early-Onset Pneumonia in Young Children Through Maternal Immunisation: A Multi-Centre Randomised Controlled Trial (PneuMatters).
Chang AB, Toombs M, Chatfield MD, Mitchell R, Fong SM, Binks MJ, Smith-Vaughan H, Pizzutto SJ, Lust K, Morris PS, Marchant JM, Yerkovich ST, O'Farrell H, Torzillo PJ, Maclennan C, Simon D, Unger HW, Ellepola H, Odendahl J, Marshall HS, Swamy GK, Grimwood K. Chang AB, et al. Among authors: grimwood k. Front Pediatr. 2022 Jan 17;9:781168. doi: 10.3389/fped.2021.781168. eCollection 2021. Front Pediatr. 2022. PMID: 35111703 Free PMC article.
Background: Preventing and/or reducing acute lower respiratory infections (ALRIs) in young children will lead to substantial short and long-term clinical benefits. While immunisation with pneumococcal conjugate vaccines (PCV) reduces paediatric ALRIs, its efficacy for redu …
Background: Preventing and/or reducing acute lower respiratory infections (ALRIs) in young children will lead to substantial short and long- …
Cord-blood respiratory syncytial virus antibodies and respiratory health in first 5 years of life.
Takashima MD, Grimwood K, Sly PD, Lambert SB, Chappell KJ, Watterson D, Young P, Kusel M, Holt B, Holt P, Ware RS. Takashima MD, et al. Among authors: grimwood k. Pediatr Pulmonol. 2021 Dec;56(12):3942-3951. doi: 10.1002/ppul.25688. Epub 2021 Sep 29. Pediatr Pulmonol. 2021. PMID: 34549896
OBJECTIVE: To determine the potential longer-term effects of maternal antenatal respiratory syncytial virus (RSV) vaccination, we examined the association between cord-blood RSV-neutralizing antibodies (RSV-NA) and RSV infections in the first 2 years of life, RSV-NA at 3 y …
OBJECTIVE: To determine the potential longer-term effects of maternal antenatal respiratory syncytial virus (RSV) vaccination, we exa …
Invasive Haemophilus influenzae Infections after 3 Decades of Hib Protein Conjugate Vaccine Use.
Slack MPE, Cripps AW, Grimwood K, Mackenzie GA, Ulanova M. Slack MPE, et al. Among authors: grimwood k. Clin Microbiol Rev. 2021 Jun 16;34(3):e0002821. doi: 10.1128/CMR.00028-21. Epub 2021 Jun 2. Clin Microbiol Rev. 2021. PMID: 34076491 Free PMC article. Review.
It discusses those now at risk of invasive Hib disease, describes the emergence of other severe invasive H. influenzae infections, and emphasizes the importance of long-term, comprehensive, clinical and microbiologic surveillance to monitor a vaccine's impact....
It discusses those now at risk of invasive Hib disease, describes the emergence of other severe invasive H. influenzae infections, and empha …
European Respiratory Society guidelines for the management of children and adolescents with bronchiectasis.
Chang AB, Fortescue R, Grimwood K, Alexopoulou E, Bell L, Boyd J, Bush A, Chalmers JD, Hill AT, Karadag B, Midulla F, McCallum GB, Powell Z, Snijders D, Song WJ, Tonia T, Wilson C, Zacharasiewicz A, Kantar A. Chang AB, et al. Among authors: grimwood k. Eur Respir J. 2021 Aug 26;58(2):2002990. doi: 10.1183/13993003.02990-2020. Print 2021 Aug. Eur Respir J. 2021. PMID: 33542057 Free article.
The outcomes for each PICO were decided by voting by the panel and parent/patient advisory group.This guideline addresses the definition, diagnostic approach and antibiotic treatment of exacerbations, pathogen eradication, long-term antibiotic therapy, asthma-type therapie …
The outcomes for each PICO were decided by voting by the panel and parent/patient advisory group.This guideline addresses the definition, di …
38 results