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The cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread.
Gomes AC, Baraniak IA, Lankina A, Moulder Z, Holenya P, Atkinson C, Tang G, Mahungu T, Kern F, Griffiths PD, Reeves MB. Gomes AC, et al. Among authors: griffiths pd. Nat Commun. 2023 Feb 23;14(1):1041. doi: 10.1038/s41467-023-36683-x. Nat Commun. 2023. PMID: 36823200 Free PMC article.
Here, we show that vaccination of CMV seronegative patients induces an antibody response against a region of gB we term AD-6. Responses to the polypeptide AD-6 are detected in >70% of vaccine recipients yet in <5% of naturally infected people. ...
Here, we show that vaccination of CMV seronegative patients induces an antibody response against a region of gB we term AD-6. Respons …
Cortical formation abnormalities on foetal MR imaging: a proposed classification system trialled on 356 cases from Italian and UK centres.
Righini A, Genovese M, Parazzini C, Severino M, Scola E, Pinelli L, Conte G, Derrico I, Di Maurizio M, Talenti G, Mandefield L, Jarvis D, Palumbo G, Guerrini R, Rossi A, Triulzi F, Griffiths PD. Righini A, et al. Among authors: griffiths pd. Eur Radiol. 2020 Oct;30(10):5250-5260. doi: 10.1007/s00330-020-06899-2. Epub 2020 May 13. Eur Radiol. 2020. PMID: 32405748
This classification system can be used in future research studies to evaluate the long-term imaging and clinical outcomes of foetal brain cortical formation abnormalities in 17- to 38-week gestational age range. ...
This classification system can be used in future research studies to evaluate the long-term imaging and clinical outcomes of foetal b …
MRI in the diagnosis of fetal developmental brain abnormalities: the MERIDIAN diagnostic accuracy study.
Griffiths PD, Bradburn M, Campbell MJ, Cooper CL, Embleton N, Graham R, Hart AR, Jarvis D, Kilby MD, Lie M, Mason G, Mandefield L, Mooney C, Pennington R, Robson SC, Wailoo A. Griffiths PD, et al. Health Technol Assess. 2019 Sep;23(49):1-144. doi: 10.3310/hta23490. Health Technol Assess. 2019. PMID: 31538569 Free PMC article. Clinical Trial.
An evaluation of the use of iuMRI for cases of isolated microcephaly and the diagnosis of fetal spine abnormalities is recommended. Longer-term follow-up studies of children diagnosed with fetal brain abnormalities are required to fully assess the functional significance o …
An evaluation of the use of iuMRI for cases of isolated microcephaly and the diagnosis of fetal spine abnormalities is recommended. Longer- …
Long-term cognitive outcomes in tuberous sclerosis complex.
Tye C, Mcewen FS, Liang H, Underwood L, Woodhouse E, Barker ED, Sheerin F, Yates JRW, Bolton PF; Tuberous Sclerosis 2000 Study Group. Tye C, et al. Dev Med Child Neurol. 2020 Mar;62(3):322-329. doi: 10.1111/dmcn.14356. Epub 2019 Sep 19. Dev Med Child Neurol. 2020. PMID: 31538337 Free PMC article.
AIM: To investigate the interdependence between risk factors associated with long-term intellectual development in individuals with tuberous sclerosis complex (TSC). ...Risk pathways through seizures in the first 2 years predict long-term cognitive outcomes in indiv …
AIM: To investigate the interdependence between risk factors associated with long-term intellectual development in individuals with t …
Compartmentalized dynamics of cytomegalovirus replication in treated congenital infection.
Luck SE, Emery VC, Atkinson C, Sharland M, Griffiths PD. Luck SE, et al. Among authors: griffiths pd. J Clin Virol. 2016 Sep;82:152-158. doi: 10.1016/j.jcv.2016.07.018. Epub 2016 Jul 27. J Clin Virol. 2016. PMID: 27500364
BACKGROUND: Cytomegalovirus (CMV) is the most prevalent congenital infection in developed countries. A significant number of infected infants develop long-term neurodevelopmental and hearing impairment irrespective of whether disease is detectable at birth. ...The d …
BACKGROUND: Cytomegalovirus (CMV) is the most prevalent congenital infection in developed countries. A significant number of infected infant …
Analysis of supratentorial cystic abnormalities using in utero MR imaging.
Warner HM, Griffiths PD. Warner HM, et al. Among authors: griffiths pd. Br J Radiol. 2016;89(1058):20150395. doi: 10.1259/bjr.20150395. Epub 2015 Nov 18. Br J Radiol. 2016. PMID: 26577541 Free PMC article.
Although this is a relatively rare clinical situation, it warrants further investigation because of the high risk of other intracranial abnormalities that are likely to cause long-term neurodevelopmental problems. METHODS: We reviewed 957 consecutive referrals for iuMR of …
Although this is a relatively rare clinical situation, it warrants further investigation because of the high risk of other intracranial abno …
Valganciclovir for symptomatic congenital cytomegalovirus disease.
Kimberlin DW, Jester PM, Sánchez PJ, Ahmed A, Arav-Boger R, Michaels MG, Ashouri N, Englund JA, Estrada B, Jacobs RF, Romero JR, Sood SK, Whitworth MS, Abzug MJ, Caserta MT, Fowler S, Lujan-Zilbermann J, Storch GA, DeBiasi RL, Han JY, Palmer A, Weiner LB, Bocchini JA, Dennehy PH, Finn A, Griffiths PD, Luck S, Gutierrez K, Halasa N, Homans J, Shane AL, Sharland M, Simonsen K, Vanchiere JA, Woods CR, Sabo DL, Aban I, Kuo H, James SH, Prichard MN, Griffin J, Giles D, Acosta EP, Whitley RJ; National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. Kimberlin DW, et al. Among authors: griffiths pd. N Engl J Med. 2015 Mar 5;372(10):933-43. doi: 10.1056/NEJMoa1404599. N Engl J Med. 2015. PMID: 25738669 Free PMC article. Clinical Trial.
CONCLUSIONS: Treating symptomatic congenital CMV disease with valganciclovir for 6 months, as compared with 6 weeks, did not improve hearing in the short term but appeared to improve hearing and developmental outcomes modestly in the longer term. ...
CONCLUSIONS: Treating symptomatic congenital CMV disease with valganciclovir for 6 months, as compared with 6 weeks, did not improve hearing …
Diffusion-weighted imaging and magnetic resonance proton spectroscopy following preterm birth.
Hart AR, Smith MF, Whitby EH, Alladi S, Wilkinson S, Paley MN, Griffiths PD. Hart AR, et al. Among authors: griffiths pd. Clin Radiol. 2014 Aug;69(8):870-9. doi: 10.1016/j.crad.2014.04.001. Epub 2014 Jun 13. Clin Radiol. 2014. PMID: 24935906
CONCLUSION: Altered NAA levels in the posterior white matter may reflect subtle white matter injury associated with neuro-developmental difficulties, which may be related to a PDA. Further work is needed to assess the longer-term neuro-developmental implications of these f …
CONCLUSION: Altered NAA levels in the posterior white matter may reflect subtle white matter injury associated with neuro-developmental diff …
In utero magnetic resonance imaging for diagnosis of dural venous sinus ectasia with thrombosis in the fetus.
Fanou EM, Reeves MJ, Howe DT, Joy H, Morris S, Russell S, Griffiths PD. Fanou EM, et al. Among authors: griffiths pd. Pediatr Radiol. 2013 Dec;43(12):1591-8. doi: 10.1007/s00247-013-2745-7. Epub 2013 Oct 15. Pediatr Radiol. 2013. PMID: 24127016
BACKGROUND: Dural venous sinus ectasia with thrombosis (DVSET) in the fetus is a rare condition that can be diagnosed prenatally with the use of fetal MR imaging, yet with limited indication of long-term clinical significance. OBJECTIVE: To describe and evaluate the diagno …
BACKGROUND: Dural venous sinus ectasia with thrombosis (DVSET) in the fetus is a rare condition that can be diagnosed prenatally with the us …
Clinically targeted screening for congenital CMV - potential for integration into the National Hearing Screening Programme.
Kadambari S, Luck S, Davis A, Williams E, Berrington J, Griffiths P, Sharland M. Kadambari S, et al. Among authors: griffiths p. Acta Paediatr. 2013 Oct;102(10):928-33. doi: 10.1111/apa.12335. Epub 2013 Aug 8. Acta Paediatr. 2013. PMID: 23927434
In the absence of any screening programme, we provide evidence that clinically targeted screening through the NHSP is a potential option in the UK, enhancing the diagnostic pathway and enabling appropriate early treatment to reduce long-term morbidity....
In the absence of any screening programme, we provide evidence that clinically targeted screening through the NHSP is a potential option in …
30 results