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Drug repurposing for the treatment of COVID-19: Targeting nafamostat to the lungs by a liposomal delivery system.
Reus P, Guthmann H, Uhlig N, Agbaria M, Issmail L, Eberlein V, Nordling-David MM, Jbara-Agbaria D, Ciesek S, Bojkova D, Cinatl J, Burger-Kentischer A, Rupp S, Zaliani A, Grunwald T, Gribbon P, Kannt A, Golomb G. Reus P, et al. Among authors: gribbon p. J Control Release. 2023 Dec;364:654-671. doi: 10.1016/j.jconrel.2023.10.050. Epub 2023 Nov 16. J Control Release. 2023. PMID: 37939853 Free article.
The developed liposomal formulations of nafamostat were found to possess favorable physicochemical properties including nano size (119-147 nm), long-term stability of the normally rapidly degrading compound in aqueous solution, negligible leakage from the liposomes upon st …
The developed liposomal formulations of nafamostat were found to possess favorable physicochemical properties including nano size (119-147 n …
Selection of data sets for FAIRification in drug discovery and development: Which, why, and how?
Alharbi E, Gadiya Y, Henderson D, Zaliani A, Delfin-Rossaro A, Cambon-Thomsen A, Kohler M, Witt G, Welter D, Juty N, Jay C, Engkvist O, Goble C, Reilly DS, Satagopam V, Ioannidis V, Gu W, Gribbon P. Alharbi E, et al. Among authors: gribbon p. Drug Discov Today. 2022 Aug;27(8):2080-2085. doi: 10.1016/j.drudis.2022.05.010. Epub 2022 May 17. Drug Discov Today. 2022. PMID: 35595012 Free PMC article. Review.
Despite the intuitive value of adopting the Findable, Accessible, Interoperable, and Reusable (FAIR) principles in both academic and industrial sectors, challenges exist in resourcing, balancing long- versus short-term priorities, and achieving technical implementation. Th …
Despite the intuitive value of adopting the Findable, Accessible, Interoperable, and Reusable (FAIR) principles in both academic and industr …
The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2.
Krasemann S, Haferkamp U, Pfefferle S, Woo MS, Heinrich F, Schweizer M, Appelt-Menzel A, Cubukova A, Barenberg J, Leu J, Hartmann K, Thies E, Littau JL, Sepulveda-Falla D, Zhang L, Ton K, Liang Y, Matschke J, Ricklefs F, Sauvigny T, Sperhake J, Fitzek A, Gerhartl A, Brachner A, Geiger N, König EM, Bodem J, Franzenburg S, Franke A, Moese S, Müller FJ, Geisslinger G, Claussen C, Kannt A, Zaliani A, Gribbon P, Ondruschka B, Neuhaus W, Friese MA, Glatzel M, Pless O. Krasemann S, et al. Among authors: gribbon p. Stem Cell Reports. 2022 Feb 8;17(2):307-320. doi: 10.1016/j.stemcr.2021.12.011. Epub 2022 Jan 20. Stem Cell Reports. 2022. PMID: 35063125 Free PMC article.