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Acute cognitive and behavioral effects of systemic corticosteroids in children treated for inflammatory bowel disease.
Mrakotsky C, Forbes PW, Bernstein JH, Grand RJ, Bousvaros A, Szigethy E, Waber DP. Mrakotsky C, et al. Among authors: grand rj. J Int Neuropsychol Soc. 2013 Jan;19(1):96-109. doi: 10.1017/S1355617712001014. Epub 2012 Nov 19. J Int Neuropsychol Soc. 2013. PMID: 23157730 Free PMC article.
Corticosteroid therapy can have acute effects on cognition, emotion, and behavior in chronically ill children; the clinical and long-term significance of these effects require further investigation....
Corticosteroid therapy can have acute effects on cognition, emotion, and behavior in chronically ill children; the clinical and long-term
Efficacy and harms of nasal calcitonin in improving bone density in young patients with inflammatory bowel disease: a randomized, placebo-controlled, double-blind trial.
Pappa HM, Saslowsky TM, Filip-Dhima R, DiFabio D, Hassani Lahsinoui H, Akkad A, Grand RJ, Gordon CM. Pappa HM, et al. Among authors: grand rj. Am J Gastroenterol. 2011 Aug;106(8):1527-43. doi: 10.1038/ajg.2011.129. Epub 2011 Apr 26. Am J Gastroenterol. 2011. PMID: 21519359 Free PMC article. Clinical Trial.
CONCLUSIONS: Intranasal calcitonin is well tolerated but does not offer a long-term advantage in youth with IBD and decreased BMD. Bone mineral accrual rate remains compromised in youth with IBD and low BMD raising concerns for long-term bone health outcomes. ...
CONCLUSIONS: Intranasal calcitonin is well tolerated but does not offer a long-term advantage in youth with IBD and decreased BMD. Bo …
Lactose malabsorption.
Grand RJ, Montgomery RK. Grand RJ, et al. Curr Treat Options Gastroenterol. 2008 Feb;11(1):19-25. doi: 10.1007/s11938-008-0003-0. Curr Treat Options Gastroenterol. 2008. PMID: 21063860
Commercial enzyme products containing beta-galactosidases can be prescribed to help patients digest dietary lactose. Long-term lactose restriction usually is not necessary and can lead to reduced bone mineral density....
Commercial enzyme products containing beta-galactosidases can be prescribed to help patients digest dietary lactose. Long-term lactos …
Vitamin D status in children and young adults with inflammatory bowel disease.
Pappa HM, Gordon CM, Saslowsky TM, Zholudev A, Horr B, Shih MC, Grand RJ. Pappa HM, et al. Among authors: grand rj. Pediatrics. 2006 Nov;118(5):1950-61. doi: 10.1542/peds.2006-0841. Pediatrics. 2006. PMID: 17079566 Free PMC article.
Factors predisposing to the problem include having a dark-skin complexion, winter season, lack of vitamin D supplementation, early stage of disease, more severe disease, and upper gastrointestinal tract involvement in patients with Crohn disease. The long-term significance …
Factors predisposing to the problem include having a dark-skin complexion, winter season, lack of vitamin D supplementation, early stage of …
Differential effects of BCL-2 on survival and proliferation of human B-lymphoma cells following gamma-irradiation.
Milner AE, Grand RJ, Vaughan AT, Armitage RJ, Gregory CD. Milner AE, et al. Among authors: grand rj. Oncogene. 1997 Oct 9;15(15):1815-22. doi: 10.1038/sj.onc.1201355. Oncogene. 1997. PMID: 9362448
In addition, in different BL lines, Bcl-2 was found either to promote or to inhibit long-term proliferative activity following gamma-irradiation. This differential regulation of proliferation correlated both with differential effects of Bcl-2 on the cell cycle and with dif …
In addition, in different BL lines, Bcl-2 was found either to promote or to inhibit long-term proliferative activity following gamma- …
Combined use of cyclosporine and azathioprine or 6-mercaptopurine in pediatric inflammatory bowel disease.
Ramakrishna J, Langhans N, Calenda K, Grand RJ, Verhave M. Ramakrishna J, et al. Among authors: grand rj. J Pediatr Gastroenterol Nutr. 1996 Apr;22(3):296-302. doi: 10.1097/00005176-199604000-00012. J Pediatr Gastroenterol Nutr. 1996. PMID: 8708884 Clinical Trial.
Of the seven responders, three were able to discontinue prednisone and cyclosporine and are doing well on azathioprine at long-term follow-up (2-5 years). One who did not receive azathioprine/6-mercaptopurine maintained remission for 2 years after cyclosporine was stopped, …
Of the seven responders, three were able to discontinue prednisone and cyclosporine and are doing well on azathioprine at long-term f …
Effects of interferon-alpha on human B cells: repression of apoptosis and prevention of cell growth are independent responses of Burkitt lymphoma lines.
Milner AE, Grand RJ, Gregory CD. Milner AE, et al. Among authors: grand rj. Int J Cancer. 1995 May 4;61(3):348-54. doi: 10.1002/ijc.2910610313. Int J Cancer. 1995. PMID: 7729947
In Daudi cells, but not in IFN-alpha-rescuable BL cells, renewed expression of myc observed after the early, transient down-regulation was followed by sustained down-regulation of the protein, which paralleled growth arrest. Our results indicate that long-term growth arres …
In Daudi cells, but not in IFN-alpha-rescuable BL cells, renewed expression of myc observed after the early, transient down-regulation was f …
Lactose intolerance and lactase deficiency in children.
Rings EH, Grand RJ, Büller HA. Rings EH, et al. Among authors: grand rj. Curr Opin Pediatr. 1994 Oct;6(5):562-7. doi: 10.1097/00008480-199410000-00010. Curr Opin Pediatr. 1994. PMID: 7820203 Review.
The term lactase deficiency is widely used to indicate a low or absent level of lactase enzyme in the small intestine, leading to lactose intolerance. This term is correctly used when the intestinal mucosa is damaged and results in secondary lactase deficiency. ...
The term lactase deficiency is widely used to indicate a low or absent level of lactase enzyme in the small intestine, leading to lac …
Azathioprine in the treatment of children with inflammatory bowel disease.
Verhave M, Winter HS, Grand RJ. Verhave M, et al. Among authors: grand rj. J Pediatr. 1990 Nov;117(5):809-14. doi: 10.1016/s0022-3476(05)83349-9. J Pediatr. 1990. PMID: 2231216
We conclude that azathioprine is an effective adjunctive agent for the treatment of inflammatory bowel disease in childhood, but because questions remain regarding its long-term safety, its use should be reserved for children with refractory disease or severe and unaccepta …
We conclude that azathioprine is an effective adjunctive agent for the treatment of inflammatory bowel disease in childhood, but because que …
Development of carbohydrate absorption in the fetus and neonate.
Mobassaleh M, Montgomery RK, Biller JA, Grand RJ. Mobassaleh M, et al. Among authors: grand rj. Pediatrics. 1985 Jan;75(1 Pt 2):160-6. Pediatrics. 1985. PMID: 2578223
The intestinal enzymes, lactase, sucrase, maltase, isomaltase, and glucoamylase, are at mature levels in the term fetus. Mature levels of pancreatic amylase activity and glucose transport occur postnatally, and levels are low in both the term and preterm neonate. .. …
The intestinal enzymes, lactase, sucrase, maltase, isomaltase, and glucoamylase, are at mature levels in the term fetus. Mature level …
18 results