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Elexacaftor/tezacaftor/ivacaftor improves chronic rhinosinusitis detected by magnetic resonance imaging in children with cystic fibrosis on long-term therapy with lumacaftor/ivacaftor.
Wucherpfennig L, Becker JKZ, Wuennemann F, Eichinger M, Seitz A, Baumann I, Stahl M, Graeber SY, Zhao S, Chung J, Schenk JP, Alrajab A, Kauczor HU, Mall MA, Sommerburg O, Wielpütz MO. Wucherpfennig L, et al. Among authors: graeber sy. J Cyst Fibros. 2024 Jan 12:S1569-1993(24)00004-3. doi: 10.1016/j.jcf.2024.01.004. Online ahead of print. J Cyst Fibros. 2024. PMID: 38218661 Free article.
Effects of lumacaftor-ivacaftor therapy on cystic fibrosis transmembrane conductance regulator function in F508del homozygous patients with cystic fibrosis aged 2-11 years.
Berges J, Graeber SY, Hämmerling S, Yu Y, Krümpelmann A, Stahl M, Hirtz S, Scheuermann H, Mall MA, Sommerburg O. Berges J, et al. Among authors: graeber sy. Front Pharmacol. 2023 May 30;14:1188051. doi: 10.3389/fphar.2023.1188051. eCollection 2023. Front Pharmacol. 2023. PMID: 37324488 Free PMC article.
Conclusion: Lumacaftor/ivacaftor partially restores F508del CFTR function in children with CF who are homozygous for F508del, aged 2-11 years, to a level of CFTR activity seen in patients with CFTR variants with residual function. These results are consistent with the partial sho …
Conclusion: Lumacaftor/ivacaftor partially restores F508del CFTR function in children with CF who are homozygous for F508del, aged 2-11 year …
Effects of elexacaftor/tezacaftor/ivacaftor therapy on mental health of patients with cystic fibrosis.
Piehler L, Thalemann R, Lehmann C, Thee S, Röhmel J, Syunyaeva Z, Stahl M, Mall MA, Graeber SY. Piehler L, et al. Among authors: graeber sy. Front Pharmacol. 2023 Apr 21;14:1179208. doi: 10.3389/fphar.2023.1179208. eCollection 2023. Front Pharmacol. 2023. PMID: 37153809 Free PMC article.
Conclusion: Initiation of ETI improves symptoms of depression in adult patients with CF with at least one F508del allele. However, symptoms of anxiety do not change after short-term therapy with ETI....
Conclusion: Initiation of ETI improves symptoms of depression in adult patients with CF with at least one F508del allele. However, symptoms …
Long-term effects of lumacaftor/ivacaftor on paranasal sinus abnormalities in children with cystic fibrosis detected with magnetic resonance imaging.
Wucherpfennig L, Wuennemann F, Eichinger M, Seitz A, Baumann I, Stahl M, Graeber SY, Zhao S, Chung J, Schenk JP, Alrajab A, Kauczor HU, Mall MA, Sommerburg O, Wielpütz MO. Wucherpfennig L, et al. Among authors: graeber sy. Front Pharmacol. 2023 Apr 10;14:1161891. doi: 10.3389/fphar.2023.1161891. eCollection 2023. Front Pharmacol. 2023. PMID: 37101549 Free PMC article.
Previous studies using magnetic resonance imaging (MRI) demonstrated early onset and progression of CRS from infancy to school age in patients with CF, and mid-term improvements of CRS in preschool and school-age children with CF treated with lumacaftor/ivacaftor for at le …
Previous studies using magnetic resonance imaging (MRI) demonstrated early onset and progression of CRS from infancy to school age in patien …
Changes in Microbiome Dominance Are Associated With Declining Lung Function and Fluctuating Inflammation in People With Cystic Fibrosis.
Frey DL, Bridson C, Dittrich S, Graeber SY, Stahl M, Wege S, Herth F, Sommerburg O, Schultz C, Dalpke A, Mall MA, Boutin S. Frey DL, et al. Among authors: graeber sy. Front Microbiol. 2022 May 13;13:885822. doi: 10.3389/fmicb.2022.885822. eCollection 2022. Front Microbiol. 2022. PMID: 35633718 Free PMC article.
However, longitudinal studies are needed to decipher which factors contribute to the long-term evolution of these key features of CF. We therefore evaluated the relationship between fluctuation in microbiome and inflammatory parameters in a longitudinal study including a s …
However, longitudinal studies are needed to decipher which factors contribute to the long-term evolution of these key features of CF. …
Effects of Lumacaftor-Ivacaftor Therapy on Cystic Fibrosis Transmembrane Conductance Regulator Function in Phe508del Homozygous Patients with Cystic Fibrosis.
Graeber SY, Dopfer C, Naehrlich L, Gyulumyan L, Scheuermann H, Hirtz S, Wege S, Mairbäurl H, Dorda M, Hyde R, Bagheri-Hanson A, Rueckes-Nilges C, Fischer S, Mall MA, Tümmler B. Graeber SY, et al. Am J Respir Crit Care Med. 2018 Jun 1;197(11):1433-1442. doi: 10.1164/rccm.201710-1983OC. Am J Respir Crit Care Med. 2018. PMID: 29327948
Functional improvement was detected even in the absence of short-term improvement of FEV(1)% predicted and body mass index. Clinical trial registered with www.clinicaltrials.gov (NCT02807415)....
Functional improvement was detected even in the absence of short-term improvement of FEV(1)% predicted and body mass index. Clinical …
Early detection and sensitive monitoring of CF lung disease: Prospects of improved and safer imaging.
Mall MA, Stahl M, Graeber SY, Sommerburg O, Kauczor HU, Wielpütz MO. Mall MA, et al. Among authors: graeber sy. Pediatr Pulmonol. 2016 Oct;51(S44):S49-S60. doi: 10.1002/ppul.23537. Pediatr Pulmonol. 2016. PMID: 27662104 Review.
In this context, the use of CT imaging for early detection and long-term monitoring has the disadvantage of the risk to induce malignancies due to cumulating ionizing radiation exposure. ...
In this context, the use of CT imaging for early detection and long-term monitoring has the disadvantage of the risk to induce malign …