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Management and outcomes in children with lupus nephritis in the developing countries.
Khandelwal P, Govindarajan S, Bagga A. Khandelwal P, et al. Among authors: govindarajan s. Pediatr Nephrol. 2023 Apr;38(4):987-1000. doi: 10.1007/s00467-022-05769-x. Epub 2022 Oct 18. Pediatr Nephrol. 2023. PMID: 36255555 Review.
OBJECTIVES: This review compares the outcomes of childhood LN in low- and middle-income countries (LMICs) and high-income countries (HICs) and aims to summarize long-term outcomes of pediatric LN from LMICs. DATA SOURCES: A systematic literature search, conducted in PubMed …
OBJECTIVES: This review compares the outcomes of childhood LN in low- and middle-income countries (LMICs) and high-income countries (HICs) a …
Functional, anatomical and diffusion tensor MRI study of radiology expertise.
Ouellette DJ, Van Staalduinen E, Hussaini SH, Govindarajan ST, Stefancin P, Hsu DL, Duong TQ. Ouellette DJ, et al. Among authors: govindarajan st. PLoS One. 2020 Apr 27;15(4):e0231900. doi: 10.1371/journal.pone.0231900. eCollection 2020. PLoS One. 2020. PMID: 32339188 Free PMC article.
BACKGROUND: Repeated practice to acquire expertise could result in the structural and functional changes in relevant brain circuits as a result of long-term potentiation, neurogenesis, glial genesis, and remodeling. PURPOSE: The goal of this study is to use task fMRI to st …
BACKGROUND: Repeated practice to acquire expertise could result in the structural and functional changes in relevant brain circuits as a res …
REDD1 induction regulates the skeletal muscle gene expression signature following acute aerobic exercise.
Gordon BS, Steiner JL, Rossetti ML, Qiao S, Ellisen LW, Govindarajan SS, Eroshkin AM, Williamson DL, Coen PM. Gordon BS, et al. Among authors: govindarajan ss. Am J Physiol Endocrinol Metab. 2017 Dec 1;313(6):E737-E747. doi: 10.1152/ajpendo.00120.2017. Epub 2017 Sep 12. Am J Physiol Endocrinol Metab. 2017. PMID: 28899858 Free PMC article.
The metabolic stress placed on skeletal muscle by aerobic exercise promotes acute and long-term health benefits in part through changes in gene expression. ...
The metabolic stress placed on skeletal muscle by aerobic exercise promotes acute and long-term health benefits in part through chang …
Predicting clinical outcomes using baseline and follow-up laboratory data from the hepatitis C long-term treatment against cirrhosis trial.
Ghany MG, Kim HY, Stoddard A, Wright EC, Seeff LB, Lok AS; HALT-C Trial Group. Ghany MG, et al. Hepatology. 2011 Nov;54(5):1527-37. doi: 10.1002/hep.24550. Hepatology. 2011. PMID: 22045670 Free PMC article.
Predicting clinical outcomes in patients with chronic hepatitis C is challenging. We used the hepatitis C long-term treatment against cirrhosis (HALT-C) trial database to develop two models, using baseline values of routinely available laboratory tests together with change …
Predicting clinical outcomes in patients with chronic hepatitis C is challenging. We used the hepatitis C long-term treatment against …
Predicting cirrhosis and clinical outcomes in patients with advanced chronic hepatitis C with a panel of genetic markers (CRS7).
Curto TM, Lagier RJ, Lok AS, Everhart JE, Rowland CM, Sninsky JJ; HALT-C Trial group. Curto TM, et al. Pharmacogenet Genomics. 2011 Dec;21(12):851-60. doi: 10.1097/FPC.0b013e32834c3e74. Pharmacogenet Genomics. 2011. PMID: 21946897 Free PMC article. Clinical Trial.
METHODS: A total of 938 patients (677 Caucasians, 165 African-Americans, and 96 Hispanic/Other) in the Hepatitis C Antiviral Long-term Treatment against Cirrhosis Trial were studied. CRS7 was categorized a priori as high risk (n=440), medium risk (n=310), or low risk (n=18 …
METHODS: A total of 938 patients (677 Caucasians, 165 African-Americans, and 96 Hispanic/Other) in the Hepatitis C Antiviral Long-term
Extended interferon-alpha therapy accelerates telomere length loss in human peripheral blood T lymphocytes.
O'Bryan JM, Potts JA, Bonkovsky HL, Mathew A, Rothman AL; HALT-C Trial Group. O'Bryan JM, et al. PLoS One. 2011;6(8):e20922. doi: 10.1371/journal.pone.0020922. Epub 2011 Aug 4. PLoS One. 2011. PMID: 21829595 Free PMC article. Clinical Trial.
BACKGROUND: Type I interferons have pleiotropic effects on host cells, including inhibiting telomerase in lymphocytes and antiviral activity. We tested the hypothesis that long-term interferon treatment would result in significant reduction in average telomere length in pe …
BACKGROUND: Type I interferons have pleiotropic effects on host cells, including inhibiting telomerase in lymphocytes and antiviral activity …
A prospective study of the rate of progression in compensated, histologically advanced chronic hepatitis C.
Dienstag JL, Ghany MG, Morgan TR, Di Bisceglie AM, Bonkovsky HL, Kim HY, Seeff LB, Szabo G, Wright EC, Sterling RK, Everson GT, Lindsay KL, Lee WM, Lok AS, Morishima C, Stoddard AM, Everhart JE; HALT-C Trial Group. Dienstag JL, et al. Hepatology. 2011 Aug;54(2):396-405. doi: 10.1002/hep.24370. Epub 2011 Jun 23. Hepatology. 2011. PMID: 21520194 Free PMC article. Clinical Trial.
The incidence of liver disease progression among subjects with histologically advanced but compensated chronic hepatitis C is incomplete. The Hepatitis C Antiviral Long-term Treatment against Cirrhosis Trial was a randomized study of 3.5 years of maintenance peginterferon …
The incidence of liver disease progression among subjects with histologically advanced but compensated chronic hepatitis C is incomplete. Th …
Excess mortality in patients with advanced chronic hepatitis C treated with long-term peginterferon.
Di Bisceglie AM, Stoddard AM, Dienstag JL, Shiffman ML, Seeff LB, Bonkovsky HL, Morishima C, Wright EC, Snow KK, Lee WM, Fontana RJ, Morgan TR, Ghany MG; HALT-C Trial Group. Di Bisceglie AM, et al. Hepatology. 2011 Apr;53(4):1100-8. doi: 10.1002/hep.24169. Hepatology. 2011. PMID: 21480316 Free PMC article. Clinical Trial.
Chronic hepatitis C virus infection can cause chronic liver disease, cirrhosis and liver cancer. The Hepatitis C Antiviral Long-term Treatment against Cirrhosis (HALT-C) Trial was a prospective, randomized controlled study of long-term, low-dose peginterferon therap …
Chronic hepatitis C virus infection can cause chronic liver disease, cirrhosis and liver cancer. The Hepatitis C Antiviral Long-term
A functional polymorphism in the epidermal growth factor gene is associated with risk for hepatocellular carcinoma.
Abu Dayyeh BK, Yang M, Fuchs BC, Karl DL, Yamada S, Sninsky JJ, O'Brien TR, Dienstag JL, Tanabe KK, Chung RT; HALT-C Trial Group. Abu Dayyeh BK, et al. Gastroenterology. 2011 Jul;141(1):141-9. doi: 10.1053/j.gastro.2011.03.045. Epub 2011 Mar 24. Gastroenterology. 2011. PMID: 21440548 Free PMC article. Clinical Trial.
METHODS: Black and white subjects from the Hepatitis C Antiviral Long-term Treatment against Cirrhosis (HALT-C) trial (n=816) were followed up prospectively for development of a definite or presumed case of HCC for a median time period of 6.1 years. ...
METHODS: Black and white subjects from the Hepatitis C Antiviral Long-term Treatment against Cirrhosis (HALT-C) trial (n=816) were fo …
Coffee consumption is associated with response to peginterferon and ribavirin therapy in patients with chronic hepatitis C.
Freedman ND, Curto TM, Lindsay KL, Wright EC, Sinha R, Everhart JE; HALT-C TRIAL GROUP. Freedman ND, et al. Gastroenterology. 2011 Jun;140(7):1961-9. doi: 10.1053/j.gastro.2011.02.061. Epub 2011 Mar 2. Gastroenterology. 2011. PMID: 21376050 Free PMC article. Clinical Trial.
METHODS: Patients (n=885) from the lead-in phase of the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis Trial recorded coffee intake before retreatment with peginterferon alpha-2a (180 mug/wk) and ribavirin (1000-1200 mg/day). ...
METHODS: Patients (n=885) from the lead-in phase of the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis Trial recorded co …
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