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Short- and long-term antibiotic treatment reduces airway and systemic inflammation in non-cystic fibrosis bronchiectasis.
Chalmers JD, Smith MP, McHugh BJ, Doherty C, Govan JR, Hill AT. Chalmers JD, et al. Among authors: govan jr. Am J Respir Crit Care Med. 2012 Oct 1;186(7):657-65. doi: 10.1164/rccm.201203-0487OC. Epub 2012 Jun 28. Am J Respir Crit Care Med. 2012. PMID: 22744718 Clinical Trial.
METHODS: The relationship between bacterial load and airway and systemic inflammation was investigated in 385 stable patients, 15 stable patients treated with intravenous antibiotics, and 34 patients with an exacerbation of bronchiectasis treated with intravenous antibiotics. Lon …
METHODS: The relationship between bacterial load and airway and systemic inflammation was investigated in 385 stable patients, 15 stable pat …
A randomized controlled trial of nebulized gentamicin in non-cystic fibrosis bronchiectasis.
Murray MP, Govan JR, Doherty CJ, Simpson AJ, Wilkinson TS, Chalmers JD, Greening AP, Haslett C, Hill AT. Murray MP, et al. Among authors: govan jr. Am J Respir Crit Care Med. 2011 Feb 15;183(4):491-9. doi: 10.1164/rccm.201005-0756OC. Epub 2010 Sep 24. Am J Respir Crit Care Med. 2011. PMID: 20870753 Clinical Trial.
RATIONALE: Bronchiectasis is a chronic debilitating disease with few evidence-based long-term treatments. OBJECTIVES: A randomized controlled trial assessing the efficacy of nebulized gentamicin therapy over 1 year in patients with non-cystic fibrosis bronchiectasis. ...At …
RATIONALE: Bronchiectasis is a chronic debilitating disease with few evidence-based long-term treatments. OBJECTIVES: A randomized co …
Evolving epidemiology of Pseudomonas aeruginosa and the Burkholderia cepacia complex in cystic fibrosis lung infection.
Govan JR, Brown AR, Jones AM. Govan JR, et al. Future Microbiol. 2007 Apr;2(2):153-64. doi: 10.2217/17460913.2.2.153. Future Microbiol. 2007. PMID: 17661652 Review.
In the absence of aggressive early therapy, it infects the majority of adult patients and determines long-term survival. The epidemiology of CF pulmonary infections continues to evolve. ...
In the absence of aggressive early therapy, it infects the majority of adult patients and determines long-term survival. The epidemio …
Spread of beta-lactam-resistant Pseudomonas aeruginosa in a cystic fibrosis clinic.
Cheng K, Smyth RL, Govan JR, Doherty C, Winstanley C, Denning N, Heaf DP, van Saene H, Hart CA. Cheng K, et al. Among authors: govan jr. Lancet. 1996 Sep 7;348(9028):639-42. doi: 10.1016/S0140-6736(96)05169-0. Lancet. 1996. PMID: 8782753
INTERPRETATION: This study provides the first molecular evidence of a long-term outbreak of P aeruginosa in a CF centre. We suggest that careful surveillance of the prevalence of antibiotic resistance in CF centres should be instituted with measures to prevent cross-infect …
INTERPRETATION: This study provides the first molecular evidence of a long-term outbreak of P aeruginosa in a CF centre. We suggest t …
Long term continuous domiciliary oxygen therapy by transtracheal catheter.
Walsh DA, Govan JR. Walsh DA, et al. Among authors: govan jr. Thorax. 1990 Jun;45(6):478-81. doi: 10.1136/thx.45.6.478. Thorax. 1990. PMID: 2118281 Free PMC article.
Long term continuous oxygen therapy improves prognosis in patients with hypoxaemic chronic airflow limitation. Transtracheal delivery of oxygen permits adequate oxygenation of such patients at lower flow rates than are required for delivery by nasal cannulas, thus increasi …
Long term continuous oxygen therapy improves prognosis in patients with hypoxaemic chronic airflow limitation. Transtracheal delivery …
Long term transtracheal oxygen delivery through microcatheter in patients with hypoxaemia due to chronic obstructive airways disease.
Banner NR, Govan JR. Banner NR, et al. Among authors: govan jr. Br Med J (Clin Res Ed). 1986 Jul 12;293(6539):111-4. doi: 10.1136/bmj.293.6539.111. Br Med J (Clin Res Ed). 1986. PMID: 3089412 Free PMC article.
Transtracheal administration of oxygen is a new technique for long term treatment. Twenty patients with hypoxaemia due to chronic obstructive airways disease were studied while receiving oxygen through a microcatheter inserted percutaneously into the trachea. ...
Transtracheal administration of oxygen is a new technique for long term treatment. Twenty patients with hypoxaemia due to chronic obs …