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The connexin 43 carboxyl terminal mimetic peptide αCT1 prompts differentiation of a collagen scar matrix in humans resembling unwounded skin.
Montgomery J, Richardson WJ, Marsh S, Rhett JM, Bustos F, Degen K, Ghatnekar GS, Grek CL, Jourdan LJ, Holmes JW, Gourdie RG. Montgomery J, et al. Among authors: gourdie rg. FASEB J. 2021 Aug;35(8):e21762. doi: 10.1096/fj.202001881R. FASEB J. 2021. PMID: 34246197 Free PMC article. Clinical Trial.
In conclusion, alphaCT1 prompts decreased directionality of fibroblast movement and the generation of a 3D collagen matrix postwounding that is similar to unwounded skin-changes that correlate with long-term improvement in scar appearance....
In conclusion, alphaCT1 prompts decreased directionality of fibroblast movement and the generation of a 3D collagen matrix postwounding that …
Development of PLGA nanoparticles for sustained release of a connexin43 mimetic peptide to target glioblastoma cells.
Roberts R, Smyth JW, Will J, Roberts P, Grek CL, Ghatnekar GS, Sheng Z, Gourdie RG, Lamouille S, Foster EJ. Roberts R, et al. Among authors: gourdie rg. Mater Sci Eng C Mater Biol Appl. 2020 Mar;108:110191. doi: 10.1016/j.msec.2019.110191. Epub 2019 Sep 12. Mater Sci Eng C Mater Biol Appl. 2020. PMID: 31923988
Sustained release formulations of alphaCT1, a 25 amino acid peptide drug, would afford lower dosing frequency in indications that require long term treatment, such as chronic wounds and cancers. In this study, rhodamine B (RhB) was used as a model drug to develop and optim …
Sustained release formulations of alphaCT1, a 25 amino acid peptide drug, would afford lower dosing frequency in indications that require lo …
Can heart function lost to disease be regenerated by therapeutic targeting of cardiac scar tissue?
Ongstad EL, Gourdie RG. Ongstad EL, et al. Among authors: gourdie rg. Semin Cell Dev Biol. 2016 Oct;58:41-54. doi: 10.1016/j.semcdb.2016.05.020. Epub 2016 May 24. Semin Cell Dev Biol. 2016. PMID: 27234380 Free PMC article. Review.
The intensive research focus on regeneration of myocardial tissues has, as of yet, only met with modest success, with no near-term prospect of improving standard-of-care for patients with heart disease. ...
The intensive research focus on regeneration of myocardial tissues has, as of yet, only met with modest success, with no near-term pr …
Impact of the controlled release of a connexin 43 peptide on corneal wound closure in an STZ model of type I diabetes.
Moore K, Ghatnekar G, Gourdie RG, Potts JD. Moore K, et al. Among authors: gourdie rg. PLoS One. 2014 Jan 23;9(1):e86570. doi: 10.1371/journal.pone.0086570. eCollection 2014. PLoS One. 2014. PMID: 24466155 Free PMC article.
Previous data suggested a rapid metabolism rate in vitro, creating an interest in long term release. Using a streptozotocin (STZ) type I diabetic rat model with a surgically induced corneal injury, we delivered alphaCT1 both directly, in a pluronic gel solution, and in a s …
Previous data suggested a rapid metabolism rate in vitro, creating an interest in long term release. Using a streptozotocin (STZ) typ …
Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1.
Rhett JM, Jourdan J, Gourdie RG. Rhett JM, et al. Among authors: gourdie rg. Mol Biol Cell. 2011 May;22(9):1516-28. doi: 10.1091/mbc.E10-06-0548. Epub 2011 Mar 16. Mol Biol Cell. 2011. PMID: 21411628 Free PMC article.
Immunoprecipitation and Duolink protein-protein interaction assays indicated that inhibition targets ZO-1 binding with Cx43 in GJs as well as connexons in an adjacent domain that we term the "perinexus." Consistent with GJ size increases being matched by decreases in conne …
Immunoprecipitation and Duolink protein-protein interaction assays indicated that inhibition targets ZO-1 binding with Cx43 in GJs as well a …
Quantitative analysis of ZO-1 colocalization with Cx43 gap junction plaques in cultures of rat neonatal cardiomyocytes.
Zhu C, Barker RJ, Hunter AW, Zhang Y, Jourdan J, Gourdie RG. Zhu C, et al. Among authors: gourdie rg. Microsc Microanal. 2005 Jun;11(3):244-8. doi: 10.1017/S143192760505049X. Microsc Microanal. 2005. PMID: 16060977
In excitable organs such as heart and brain, GJs configure extended intercellular pathways for stable and long-term propagation of action potential. In a previous study in adult rat heart, we have shown that the Drosophila disks-large related protein ZO-1 shows low to mode …
In excitable organs such as heart and brain, GJs configure extended intercellular pathways for stable and long-term propagation of ac …
A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages.
Nguyên-Trân VT, Kubalak SW, Minamisawa S, Fiset C, Wollert KC, Brown AB, Ruiz-Lozano P, Barrere-Lemaire S, Kondo R, Norman LW, Gourdie RG, Rahme MM, Feld GK, Clark RB, Giles WR, Chien KR. Nguyên-Trân VT, et al. Among authors: gourdie rg. Cell. 2000 Sep 1;102(5):671-82. doi: 10.1016/s0092-8674(00)00089-1. Cell. 2000. PMID: 11007485 Free article.
HF-1 b, an SP1 -related transcription factor, is preferentially expressed in the cardiac conduction system and ventricular myocytes in the heart. Mice deficient for HF-1 b survive to term and exhibit normal cardiac structure and function but display sudden cardiac death an …
HF-1 b, an SP1 -related transcription factor, is preferentially expressed in the cardiac conduction system and ventricular myocytes in the h …
Identification of two further gap-junctional proteins, connexin40 and connexin45, in human myometrial smooth muscle cells at term.
Kilarski WM, Dupont E, Coppen S, Yeh HI, Vozzi C, Gourdie RG, Rezapour M, Ulmsten U, Roomans GM, Severs NJ. Kilarski WM, et al. Among authors: gourdie rg. Eur J Cell Biol. 1998 Jan;75(1):1-8. doi: 10.1016/S0171-9335(98)80040-X. Eur J Cell Biol. 1998. PMID: 9523149
In humans and other mammals, gap junctions are scarce in the myometrium of the non-pregnant uterus, but become abundant at term and/or with the onset of labor. Previous work has shown that the gap-junctional protein (connexin) expressed by human myometrial smooth muscle ce …
In humans and other mammals, gap junctions are scarce in the myometrium of the non-pregnant uterus, but become abundant at term and/o …
Quantitative immunoconfocal analysis of human myometrial gap junction connexin43 in relation to steroid hormone concentrations at term labour.
Rezapour M, Kilarski WM, Severs NJ, Gourdie RG, Rothery S, Bäckström T, Roomans GM, Ulmsten U. Rezapour M, et al. Among authors: gourdie rg. Hum Reprod. 1997 Jan;12(1):159-66. doi: 10.1093/humrep/12.1.159. Hum Reprod. 1997. PMID: 9043922
Three groups of patients were investigated: (i) before labour (at term), (ii) normal labour and (iii) oxytocin-resistant dystocia (eight patients per group). ...
Three groups of patients were investigated: (i) before labour (at term), (ii) normal labour and (iii) oxytocin-resistant dystocia (ei …
Gap junction density in human myometrium at term revealed by an anti-peptide antibody and laser scanning confocal microscopy.
Kilarski WM, Severs NJ, Gourdie RG, Rezapour M, Bäckström T, Roomans GM, Ulmsten U. Kilarski WM, et al. Among authors: gourdie rg. Folia Histochem Cytobiol. 1993;31(4):155-60. Folia Histochem Cytobiol. 1993. PMID: 8137995
The concept that the progesterone-estrogen ratio determines gap junction abundance in myometrium has developed from studies in laboratory animals. In the humans, however, gap junctions form in abundance at term despite a high progesterone-estrogen ratio. We have therefore …
The concept that the progesterone-estrogen ratio determines gap junction abundance in myometrium has developed from studies in laboratory an …