Polylactide Degradation Activates Immune Cells by Metabolic Reprogramming.
Maduka CV, Alhaj M, Ural E, Habeeb OM, Kuhnert MM, Smith K, Makela AV, Pope H, Chen S, Hix JM, Mallett CL, Chung SJ, Hakun M, Tundo A, Zinn KR, Hankenson KD, Goodman SB, Narayan R, Contag CH.
Maduka CV, et al. Among authors: goodman sb.
Adv Sci (Weinh). 2023 Nov;10(31):e2304632. doi: 10.1002/advs.202304632. Epub 2023 Sep 22.
Adv Sci (Weinh). 2023.
PMID: 37737614
Free PMC article.
Using a bioenergetic model, delayed cellular changes were observed that are not apparent in the short-term. Amorphous and semi-crystalline PLA degradation products, including monomeric l-lactic acid, mechanistically remodel metabolism in cells leading to a reactive immune …
Using a bioenergetic model, delayed cellular changes were observed that are not apparent in the short-term. Amorphous and semi-crysta …