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Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning.
Nickbakhsh S, Hughes J, Christofidis N, Griffiths E, Shaaban S, Enright J, Smollett K, Nomikou K, Palmalux N, Tong L, Carmichael S, Sreenu VB, Orton R, Goldstein EJ, Tomb RM; COVID-19 Genomics UK (COG-UK) Consortium; Templeton K, Gunson RN, da Silva Filipe A, Milosevic C, Thomson E, Robertson DL, Holden MTG, Illingworth CJR, Smith-Palmer A. Nickbakhsh S, et al. Sci Rep. 2022 Jul 19;12(1):11735. doi: 10.1038/s41598-022-15661-1. Sci Rep. 2022. PMID: 35853960 Free PMC article.
One setting at continued risk of COVID-19 outbreaks are higher education institutions, associated with student movements at the start of term, close living conditions within residential halls, and high social contact rates. ...The impact of student infections on the local …
One setting at continued risk of COVID-19 outbreaks are higher education institutions, associated with student movements at the start of …
The role of viral genomics in understanding COVID-19 outbreaks in long-term care facilities.
Aggarwal D, Myers R, Hamilton WL, Bharucha T, Tumelty NM, Brown CS, Meader EJ, Connor T, Smith DL, Bradley DT, Robson S, Bashton M, Shallcross L, Zambon M, Goodfellow I, Chand M, O'Grady J, Török ME, Peacock SJ, Page AJ; COVID-19 Genomics UK (COG-UK) Consortium. Aggarwal D, et al. Among authors: goodfellow i. Lancet Microbe. 2022 Feb;3(2):e151-e158. doi: 10.1016/S2666-5247(21)00208-1. Epub 2021 Sep 29. Lancet Microbe. 2022. PMID: 34608459 Free PMC article. Review.
We reviewed all genomic epidemiology studies on COVID-19 in long-term care facilities (LTCFs) that had been published to date. We found that staff and residents were usually infected with identical, or near identical, SARS-CoV-2 genomes. ...
We reviewed all genomic epidemiology studies on COVID-19 in long-term care facilities (LTCFs) that had been published to date. We fou …
Single-dose BNT162b2 vaccine protects against asymptomatic SARS-CoV-2 infection.
Jones NK, Rivett L, Seaman S, Samworth RJ, Warne B, Workman C, Ferris M, Wright J, Quinnell N, Shaw A; Cambridge COVID-19 Collaboration; Goodfellow IG, Lehner PJ, Howes R, Wright G, Matheson NJ, Weekes MP. Jones NK, et al. Among authors: goodfellow ig. Elife. 2021 Apr 8;10:e68808. doi: 10.7554/eLife.68808. Elife. 2021. PMID: 33830018 Free PMC article.
Here, we evaluate the effect of first-dose BNT162b2 vaccination on test positivity rates and find a fourfold reduction in asymptomatic infection amongst HCWs 12 days post-vaccination. These data provide real-world evidence of short-term protection against asymptomatic SARS …
Here, we evaluate the effect of first-dose BNT162b2 vaccination on test positivity rates and find a fourfold reduction in asymptomatic infec …
Epigenetic Suppression of Interferon Lambda Receptor Expression Leads to Enhanced Human Norovirus Replication In Vitro.
Arthur SE, Sorgeloos F, Hosmillo M, Goodfellow IG. Arthur SE, et al. Among authors: goodfellow ig. mBio. 2019 Oct 1;10(5):e02155-19. doi: 10.1128/mBio.02155-19. mBio. 2019. PMID: 31575769 Free PMC article.
This study unravels for the first time epigenetic reprogramming of the interferon lambda receptor as a new mechanism of cellular adaptation during long-term RNA virus replication and shows that an endogenous level of interferon lambda signaling is able to control human nor …
This study unravels for the first time epigenetic reprogramming of the interferon lambda receptor as a new mechanism of cellular adaptation …
The molecular pathology of noroviruses.
Karst SM, Zhu S, Goodfellow IG. Karst SM, et al. Among authors: goodfellow ig. J Pathol. 2015 Jan;235(2):206-16. doi: 10.1002/path.4463. J Pathol. 2015. PMID: 25312350 Review.
Whilst infection of the intestine is the norm, extraintestinal spread and associated pathologies have also been described. In addition, long-term chronic infections are now recognized as a significant cause of morbidity and mortality in the immunocompromised. ...
Whilst infection of the intestine is the norm, extraintestinal spread and associated pathologies have also been described. In addition, long …
Pathology caused by persistent murine norovirus infection.
Shortland A, Chettle J, Archer J, Wood K, Bailey D, Goodfellow I, Blacklaws BA, Heeney JL. Shortland A, et al. Among authors: goodfellow i. J Gen Virol. 2014 Feb;95(Pt 2):413-422. doi: 10.1099/vir.0.059188-0. Epub 2013 Nov 13. J Gen Virol. 2014. PMID: 24225497 Free PMC article.
Most significantly, this was associated with liver lesions in all the subclinically infected WT mice. These data confirmed that long-term persistence in WT mice is established with specific variants of MNV and that despite a subclinical presentation, active foci of acute i …
Most significantly, this was associated with liver lesions in all the subclinically infected WT mice. These data confirmed that long-term …
Progress towards the prevention and treatment of norovirus infections.
Arias A, Emmott E, Vashist S, Goodfellow I. Arias A, et al. Among authors: goodfellow i. Future Microbiol. 2013 Nov;8(11):1475-87. doi: 10.2217/fmb.13.109. Future Microbiol. 2013. PMID: 24199805 Free PMC article. Review.
Recent work has highlighted that, while typically an acute infection in the population, immunocompromised patients often experience long-term infections that may last many years. This cohort of patients and those regularly exposed to infectious material, for example, care …
Recent work has highlighted that, while typically an acute infection in the population, immunocompromised patients often experience long- …