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Long-term erythropoietin expression in rodents and non-human primates following intramuscular injection of a replication-defective adenoviral vector.
Hum Gene Ther. 1997 Oct 10;8(15):1797-806. doi: 10.1089/hum.1997.8.15-1797.
Hum Gene Ther. 1997.
PMID: 9358029
Our results demonstrate that there is a threshold dose of virus (2.5-8 x 10(7) pfu/gram of body weight) which is required to obtain long-term Epo expression and polycythemia in both species. A single i.m. injection of mice with 10(9) pfu of an RDAd encoding murine Epo (Adm …
Our results demonstrate that there is a threshold dose of virus (2.5-8 x 10(7) pfu/gram of body weight) which is required to obtain long- …
Long-term expression of erythropoietin in the systemic circulation of mice after intramuscular injection of a plasmid DNA vector.
Tripathy SK, Svensson EC, Black HB, Goldwasser E, Margalith M, Hobart PM, Leiden JM.
Tripathy SK, et al. Among authors: goldwasser e.
Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10876-80. doi: 10.1073/pnas.93.20.10876.
Proc Natl Acad Sci U S A. 1996.
PMID: 8855275
Free PMC article.
In this report, we describe the development of a novel muscle-based gene transfer approach that produces long-term expression of physiologically significant levels of Epo in the systemic circulation of mice. ...
In this report, we describe the development of a novel muscle-based gene transfer approach that produces long-term expression of phys …
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Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors.
Tripathy SK, Black HB, Goldwasser E, Leiden JM.
Tripathy SK, et al. Among authors: goldwasser e.
Nat Med. 1996 May;2(5):545-50. doi: 10.1038/nm0596-545.
Nat Med. 1996.
PMID: 8616713
Our results demonstrate that immune responses direct against foreign transgene-encoded proteins are the major determinants of the stability of gene expression following i.m. injection of RDAd. Moreover, we demonstrate long-term recombinant gene expression in immunocompeten …
Our results demonstrate that immune responses direct against foreign transgene-encoded proteins are the major determinants of the stability …
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Erythrocytosis in patients on long-term hemodialysis.
Shalhoub RJ, Rajan U, Kim VV, Goldwasser E, Kark JA, Antoniou LD.
Shalhoub RJ, et al. Among authors: goldwasser e.
Ann Intern Med. 1982 Nov;97(5):686-90. doi: 10.7326/0003-4819-97-5-686.
Ann Intern Med. 1982.
PMID: 7137732
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