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Effect of nusinersen on motor, respiratory and bulbar function in early-onset spinal muscular atrophy.
Brain. 2023 Feb 13;146(2):668-677. doi: 10.1093/brain/awac252.
Brain. 2023.
PMID: 35857854
Three different drugs have been approved by the European Medicines Agency and Food and Drug Administration for the treatment of spinal muscular atrophy patients, however, long-term experience is still scarce. In contrast to clinical trial data with restricted patient popul …
Three different drugs have been approved by the European Medicines Agency and Food and Drug Administration for the treatment of spinal muscu …
Overexpression of PDE4A Acts as Checkpoint Inhibitor Against cAMP-Mediated Immunosuppression in vitro.
Schmetterer KG, Goldhahn K, Ziegler LS, Gerner MC, Schmidt RLJ, Themanns M, Zebedin-Brandl E, Trapin D, Leitner J, Pickl WF, Steinberger P, Schwarzinger I, Marculescu R.
Schmetterer KG, et al. Among authors: goldhahn k.
Front Immunol. 2019 Jul 30;10:1790. doi: 10.3389/fimmu.2019.01790. eCollection 2019.
Front Immunol. 2019.
PMID: 31417563
Free PMC article.
Similarly, expression of surface markers associated with T-cell exhaustion were not influenced by PDE4A overexpression in long term cultures. Thus, we provide first in vitro evidence that PDE4A can be exploited as immune checkpoint inhibitor against multiple suppressive fa …
Similarly, expression of surface markers associated with T-cell exhaustion were not influenced by PDE4A overexpression in long term c …
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