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Impact of antenatal antiretroviral drug exposure on the growth of children who are HIV-exposed uninfected: the national South African Prevention of Mother to Child Evaluation cohort study.
Ramokolo V, Kuhn L, Lombard C, Jackson D, Goga AE. Ramokolo V, et al. Among authors: goga ae. BMC Infect Dis. 2022 Dec 6;22(1):908. doi: 10.1186/s12879-022-07847-9. BMC Infect Dis. 2022. PMID: 36474212 Free PMC article.
RESULTS: Among 2526 CHEU, 617 (24.4%) were exposed to ART since -pregnancy (pre-conception ART), 782 (31.0%) to ART commencing post-conception, 879 (34.8%) to maternal ARV prophylaxis (Azidothymidine (AZT)), and 248 (9.8%) had no ARV exposure. In unadjusted analyses, preterm b …
RESULTS: Among 2526 CHEU, 617 (24.4%) were exposed to ART since -pregnancy (pre-conception ART), 782 (31.0%) to ART commencing post-concepti …
Paediatric hospitalisations due to COVID-19 during the first SARS-CoV-2 omicron (B.1.1.529) variant wave in South Africa: a multicentre observational study.
Cloete J, Kruger A, Masha M, du Plessis NM, Mawela D, Tshukudu M, Manyane T, Komane L, Venter M, Jassat W, Goga A, Feucht U. Cloete J, et al. Among authors: goga a. Lancet Child Adolesc Health. 2022 May;6(5):294-302. doi: 10.1016/S2352-4642(22)00027-X. Epub 2022 Feb 18. Lancet Child Adolesc Health. 2022. PMID: 35189083 Free PMC article.
INTERPRETATION: Rapid increases in paediatric COVID-19 cases and hospitalisations mirror high community transmission of the SARS-CoV-2 omicron variant in Tshwane District, South Africa. Continued monitoring is needed to understand the long-term effect of the omicron varian …
INTERPRETATION: Rapid increases in paediatric COVID-19 cases and hospitalisations mirror high community transmission of the SARS-CoV-2 omicr …
Longitudinal Follow-Up of Blood Telomere Length in HIV-Exposed Uninfected Children Having Received One Year of Lopinavir/Ritonavir or Lamivudine as Prophylaxis.
Monnin A, Vizeneux A, Nagot N, Eymard-Duvernay S, Meda N, Singata-Madliki M, Ndeezi G, Tumwine JK, Kankasa C, Goga A, Tylleskär T, Van de Perre P, Molès JP. Monnin A, et al. Among authors: goga a. Children (Basel). 2021 Sep 10;8(9):796. doi: 10.3390/children8090796. Children (Basel). 2021. PMID: 34572228 Free PMC article.
Telomere shortening can be enhanced upon human immunodeficiency virus (HIV) infection and by antiretroviral (ARV) exposures. The aim of this study was to evaluate the acute and long-term effect on telomere shortening of two ARV prophylaxes, lopinavir/ritonavir (LPV/r) and …
Telomere shortening can be enhanced upon human immunodeficiency virus (HIV) infection and by antiretroviral (ARV) exposures. The aim of this …
Mitochondrial DNA Parameters in Blood of Infants Receiving Lopinavir/Ritonavir or Lamivudine Prophylaxis to Prevent Breastfeeding Transmission of HIV-1.
Monnin A, Nagot N, Periès M, Vallo R, Meda N, Singata-Madliki M, Tumwine JK, Kankasa C, Ngandu N, Goga A, Reynier P, Tylleskär T, Van de Perre P, Molès JP. Monnin A, et al. Among authors: goga a. J Clin Med. 2020 Sep 14;9(9):2972. doi: 10.3390/jcm9092972. J Clin Med. 2020. PMID: 32937988 Free PMC article.
Moreover, the proportion of children with MDD was unexpectedly high before randomisation in both groups. Long-term health impacts of these mitochondrial DNA parameters should be investigated further for both CHEU and HIV-infected children receiving LPV/r- or 3TC- based reg …
Moreover, the proportion of children with MDD was unexpectedly high before randomisation in both groups. Long-term health impacts of …
MicroRNA-342-3p is a potent tumour suppressor in hepatocellular carcinoma.
Komoll RM, Hu Q, Olarewaju O, von Döhlen L, Yuan Q, Xie Y, Tsay HC, Daon J, Qin R, Manns MP, Sharma AD, Goga A, Ott M, Balakrishnan A. Komoll RM, et al. Among authors: goga a. J Hepatol. 2021 Jan;74(1):122-134. doi: 10.1016/j.jhep.2020.07.039. Epub 2020 Jul 30. J Hepatol. 2021. PMID: 32738449
There are currently no systemic therapies for HCC that can significantly prolong long-term survival. Thus, novel effective treatment options are urgently required. ...
There are currently no systemic therapies for HCC that can significantly prolong long-term survival. Thus, novel effective treatment …
The impact of health programmes to prevent vertical transmission of HIV. Advances, emerging health challenges and research priorities for children exposed to or living with HIV: Perspectives from South Africa.
Goga A, Slogrove A, Wedderburn CJ, Feucht U, Wessels J, Ramokolo V, Bhana A, Du Plessis N, Green RJ, Pillay Y, Sherman G. Goga A, et al. S Afr Med J. 2019 Dec 5;109(11b):77-82. doi: 10.7196/SAMJ.2019.v109i11b.14292. S Afr Med J. 2019. PMID: 32252873
Current research priorities include understanding the mechanisms of preterm birth in women living with HIV to optimise preventive interventions; establishing pregnancy pharmacovigilance systems to understand the short-, medium- and long-term impact of in utero ART a …
Current research priorities include understanding the mechanisms of preterm birth in women living with HIV to optimise preventive int …
An approach for evaluating early and long term mother-to-child transmission of HIV (MTCT) in low and middle income countries: a South African experience.
Jackson DJ, Dinh TH, Lombard CJ, Sherman GG, Goga AE. Jackson DJ, et al. Among authors: goga ae. BMC Infect Dis. 2019 Sep 16;19(Suppl 1):784. doi: 10.1186/s12879-019-4336-1. BMC Infect Dis. 2019. PMID: 31526367 Free PMC article.
All findings were adjusted for study design, non-response, and weighted for number of South African live-birth in each study round. In 2012 a national closed cohort of these 4 to 8-week old infants testing EIA positive (HIV Exposed Infants) from the 2012-2013 cross-section …
All findings were adjusted for study design, non-response, and weighted for number of South African live-birth in each study round. I …
Unmasking the vulnerabilities of uninfected children exposed to HIV.
Ramokolo V, Goga AE, Slogrove AL, Powis KM. Ramokolo V, et al. Among authors: goga ae. BMJ. 2019 Aug 5;366:l4479. doi: 10.1136/bmj.l4479. BMJ. 2019. PMID: 31383646 Free PMC article.
Although programmes to reduce vertical transmission of HIV mean fewer children are acquiring HIV, more needs to be done to understand the longer term outcomes of exposure, say Vundli Ramokolo and colleagues...
Although programmes to reduce vertical transmission of HIV mean fewer children are acquiring HIV, more needs to be done to understand the lo …
How ready are our health systems to implement prevention of mother to child transmission Option B+?
Nkomo P, Davies N, Sherman G, Bhardwaj S, Ramokolo V, Ngandu NK, Noveve N, Ramraj T, Magasana V, Singh Y, Nsibande D, Goga AE. Nkomo P, et al. Among authors: goga ae. South Afr J HIV Med. 2015 Oct 7;16(1):386. doi: 10.4102/sajhivmed.v16i1.386. eCollection 2015. South Afr J HIV Med. 2015. PMID: 29568595 Free PMC article.
Implementing these guidelines should make it possible to eliminate mother to child transmission (MTCT) of HIV and improve long-term maternal and infant outcomes. The present article summarises the key recommendations of the 2015 guidelines and highlights current gaps that …
Implementing these guidelines should make it possible to eliminate mother to child transmission (MTCT) of HIV and improve long-term m …
First population-level effectiveness evaluation of a national programme to prevent HIV transmission from mother to child, South Africa.
Goga AE, Dinh TH, Jackson DJ, Lombard C, Delaney KP, Puren A, Sherman G, Woldesenbet S, Ramokolo V, Crowley S, Doherty T, Chopra M, Shaffer N, Pillay Y; South Africa PMTCT Evaluation Team. Goga AE, et al. J Epidemiol Community Health. 2015 Mar;69(3):240-8. doi: 10.1136/jech-2014-204535. Epub 2014 Nov 4. J Epidemiol Community Health. 2015. PMID: 25371480 Free PMC article.
Findings were adjusted for non-response, survey design and weighted for live-birth distributions. RESULTS: Nationally, 32% of live infants were HEI; early mother-to-child transmission (MTCT) was 3.5% (95% CI 2.9% to 4.1%). ...CONCLUSIONS: SA, a high-HIV-prevalence middle i …
Findings were adjusted for non-response, survey design and weighted for live-birth distributions. RESULTS: Nationally, 32% of live in …
11 results