Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma.
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Noorani A, et al. Among authors: goddard m.
Nat Genet. 2020 Jan;52(1):74-83. doi: 10.1038/s41588-019-0551-3. Epub 2020 Jan 6.
Nat Genet. 2020.
PMID: 31907488
Free PMC article.
Whole-genome sequencing and phylogenetic analysis of 388 samples across 18 individuals with EAC showed, in 90% of patients, that multiple subclones from the primary tumor spread very rapidly from the primary site to form multiple metastases, including lymph nodes and distant tiss …
Whole-genome sequencing and phylogenetic analysis of 388 samples across 18 individuals with EAC showed, in 90% of patients, that multiple su …