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Carbon Monoxide Poisoning: From Microbes to Therapeutics.
Dent MR, Rose JJ, Tejero J, Gladwin MT. Dent MR, et al. Among authors: gladwin mt. Annu Rev Med. 2024 Jan 29;75:337-351. doi: 10.1146/annurev-med-052422-020045. Epub 2023 Aug 15. Annu Rev Med. 2024. PMID: 37582490 Free article. Review.
Carbon monoxide (CO) poisoning leads to 50,000-100,000 emergency room visits and 1,500-2,000 deaths each year in the United States alone. Even with treatment, survivors often suffer from long-term cardiac and neurocognitive deficits, highlighting a clear unmet medical need …
Carbon monoxide (CO) poisoning leads to 50,000-100,000 emergency room visits and 1,500-2,000 deaths each year in the United States alone. Ev …
Variant-specific inflation factors for assessing population stratification at the phenotypic variance level.
Sofer T, Zheng X, Laurie CA, Gogarten SM, Brody JA, Conomos MP, Bis JC, Thornton TA, Szpiro A, O'Connell JR, Lange EM, Gao Y, Cupples LA, Psaty BM; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Rice KM. Sofer T, et al. Nat Commun. 2021 Jun 9;12(1):3506. doi: 10.1038/s41467-021-23655-2. Nat Commun. 2021. PMID: 34108454 Free PMC article.
We consider the impact of differential phenotype variances by study, which we term 'variance stratification'. Unaccounted for, variance stratification can lead to both decreased statistical power, and increased false positives rates, depending on how allele frequencies, sa …
We consider the impact of differential phenotype variances by study, which we term 'variance stratification'. Unaccounted for, varian …
Clinical Outcomes and Mortality Impact of Hyperbaric Oxygen Therapy in Patients With Carbon Monoxide Poisoning.
Rose JJ, Nouraie M, Gauthier MC, Pizon AF, Saul MI, Donahoe MP, Gladwin MT. Rose JJ, et al. Among authors: gladwin mt. Crit Care Med. 2018 Jul;46(7):e649-e655. doi: 10.1097/CCM.0000000000003135. Crit Care Med. 2018. PMID: 29629990 Free PMC article.
Hyperbaric oxygen therapy has shown benefit on reducing the long-term neurologic sequelae of carbon monoxide poisoning but has not demonstrated improved survival. The objective of this study is to assess the efficacy of hyperbaric oxygen for acute and long-term mort …
Hyperbaric oxygen therapy has shown benefit on reducing the long-term neurologic sequelae of carbon monoxide poisoning but has not de …
Carbon Monoxide Poisoning: Pathogenesis, Management, and Future Directions of Therapy.
Rose JJ, Wang L, Xu Q, McTiernan CF, Shiva S, Tejero J, Gladwin MT. Rose JJ, et al. Among authors: gladwin mt. Am J Respir Crit Care Med. 2017 Mar 1;195(5):596-606. doi: 10.1164/rccm.201606-1275CI. Am J Respir Crit Care Med. 2017. PMID: 27753502 Free PMC article. Review.
A significant number of patients who survive CO poisoning suffer from long-term neurological and affective sequelae. The neurologic deficits do not necessarily correlate with blood CO levels but likely result from the pleiotropic effects of CO on cellular mitochondrial res …
A significant number of patients who survive CO poisoning suffer from long-term neurological and affective sequelae. The neurologic d …
Liver injury is associated with mortality in sickle cell disease.
Feld JJ, Kato GJ, Koh C, Shields T, Hildesheim M, Kleiner DE, Taylor JG 6th, Sandler NG, Douek D, Haynes-Williams V, Nichols JS, Hoofnagle JH, Jake Liang T, Gladwin MT, Heller T. Feld JJ, et al. Among authors: gladwin mt. Aliment Pharmacol Ther. 2015 Oct;42(7):912-21. doi: 10.1111/apt.13347. Epub 2015 Aug 3. Aliment Pharmacol Ther. 2015. PMID: 26235444 Free PMC article.
BACKGROUND: Increased life expectancy in sickle cell disease (SCD) has resulted in greater recognition of the consequences of repeated intravascular vaso-occlusion and chronic haemolysis to multiple organ systems. AIM: To report the long-term consequences of liver dysfunct …
BACKGROUND: Increased life expectancy in sickle cell disease (SCD) has resulted in greater recognition of the consequences of repeated intra …
Characterization of right ventricular remodeling in pulmonary hypertension associated with patient outcomes by 3-dimensional wall motion tracking echocardiography.
Ryo K, Goda A, Onishi T, Delgado-Montero A, Tayal B, Champion HC, Simon MA, Mathier MA, Gladwin MT, Gorcsan J 3rd. Ryo K, et al. Among authors: gladwin mt. Circ Cardiovasc Imaging. 2015 Jun;8(6):e003176. doi: 10.1161/CIRCIMAGING.114.003176. Circ Cardiovasc Imaging. 2015. PMID: 26038432
We hypothesized that novel 3-dimensional (3D) wall motion tracking echocardiography can differentiate morphological features of RV adaption from adverse remodeling heralding an unfavorable short-term prognosis in patients with PH. METHODS AND RESULTS: We studied 112 subjec …
We hypothesized that novel 3-dimensional (3D) wall motion tracking echocardiography can differentiate morphological features of RV adaption …
Pulmonary hypertension: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases.
Austin ED, Kawut SM, Gladwin MT, Abman SH. Austin ED, et al. Among authors: gladwin mt. Ann Am Thorac Soc. 2014 Apr;11 Suppl 3(Suppl 3):S178-85. doi: 10.1513/AnnalsATS.201312-443LD. Ann Am Thorac Soc. 2014. PMID: 24754827 Free PMC article. Review.
Several factors pose immediate challenges to the development of strategies for primary prevention of PAH, including: (1) the idiopathic or primary form of the disease is extremely rare, limiting screening practicality; (2) methods for the detection of preclinical PVD are currentl …
Several factors pose immediate challenges to the development of strategies for primary prevention of PAH, including: (1) the idiopathic or p …
Echocardiographic markers of elevated pulmonary pressure and left ventricular diastolic dysfunction are associated with exercise intolerance in adults and adolescents with homozygous sickle cell anemia in the United States and United Kingdom.
Sachdev V, Kato GJ, Gibbs JS, Barst RJ, Machado RF, Nouraie M, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli EM, Girgis RE, Morris CR, Rosenzweig EB, Badesch DB, Lanzkron S, Castro OL, Taylor JG 6th, Hannoush H, Goldsmith JC, Gladwin MT, Gordeuk VR; Walk-PHASST Investigators. Sachdev V, et al. Among authors: gladwin mt. Circulation. 2011 Sep 27;124(13):1452-60. doi: 10.1161/CIRCULATIONAHA.111.032920. Epub 2011 Sep 6. Circulation. 2011. PMID: 21900080 Free PMC article. Clinical Trial.
Controlled trials investigating whether strategies to prevent or delay pulmonary hypertension and/or LV diastolic dysfunction will improve exercise capacity and long-term outcomes in sickle cell anemia should be considered. Clinical Trial Registration- URL: http://www.clin …
Controlled trials investigating whether strategies to prevent or delay pulmonary hypertension and/or LV diastolic dysfunction will improve e …
Elevated tricuspid regurgitation velocity and decline in exercise capacity over 22 months of follow up in children and adolescents with sickle cell anemia.
Gordeuk VR, Minniti CP, Nouraie M, Campbell AD, Rana SR, Luchtman-Jones L, Sable C, Dham N, Ensing G, Prchal JT, Kato GJ, Gladwin MT, Castro OL. Gordeuk VR, et al. Among authors: gladwin mt. Haematologica. 2011 Jan;96(1):33-40. doi: 10.3324/haematol.2010.030767. Epub 2010 Sep 30. Haematologica. 2011. PMID: 20884713 Free PMC article.
In pathway analysis, higher baseline hemolytic component and E/Etdi predicted elevated tricuspid regurgitation velocity at both baseline and follow up, and these elevations in turn predicted decline in six-minute-walk distance. CONCLUSIONS: Further studies should define the long- …
In pathway analysis, higher baseline hemolytic component and E/Etdi predicted elevated tricuspid regurgitation velocity at both baseline and …
Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation.
Williams KM, Chien JW, Gladwin MT, Pavletic SZ. Williams KM, et al. Among authors: gladwin mt. JAMA. 2009 Jul 15;302(3):306-14. doi: 10.1001/jama.2009.1018. JAMA. 2009. PMID: 19602690 Free PMC article.
With improvements in supportive care, both long-term survival following allogeneic hematopoietic stem cell transplantations (HSCTs) and the indications for this procedure have increased. As a result, the number of patients living with long-term toxic effects due to …
With improvements in supportive care, both long-term survival following allogeneic hematopoietic stem cell transplantations (HSCTs) a …
14 results