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Progress in Respiratory Gene Therapy.
McLachlan G, Alton EWFW, Boyd AC, Clarke NK, Davies JC, Gill DR, Griesenbach U, Hickmott JW, Hyde SC, Miah KM, Molina CJ. McLachlan G, et al. Among authors: gill dr. Hum Gene Ther. 2022 Sep;33(17-18):893-912. doi: 10.1089/hum.2022.172. Hum Gene Ther. 2022. PMID: 36074947 Free PMC article. Review.
In addition, the inclusion of features such as codon optimization and promoters providing long-term expression have improved the expression characteristics of therapeutic transgenes. ...
In addition, the inclusion of features such as codon optimization and promoters providing long-term expression have improved the expr …
Intranasal Lentiviral Vector-Mediated Antibody Delivery Confers Reduction of SARS-CoV-2 Infection in Elderly and Immunocompromised Mice.
Du Y, Zhang S, Zhang Z, Miah KM, Wei P, Zhang L, Zhu Y, Li Z, Ye F, Gill DR, Hyde SC, Wang Y, Zhao J. Du Y, et al. Among authors: gill dr. Front Immunol. 2022 Apr 22;13:819058. doi: 10.3389/fimmu.2022.819058. eCollection 2022. Front Immunol. 2022. PMID: 35529866 Free PMC article.
The NC0321 IgG1 expression in the proximal airway, expressed by a single direct in-vivo intranasal (I.N.) administration of a self-inactivating and recombinant lentiviral vector (rSIV.F/HN-NC0321), can protect young, elderly, and immunocompromised mice against mouse-adapted SARS- …
The NC0321 IgG1 expression in the proximal airway, expressed by a single direct in-vivo intranasal (I.N.) administration of a self-inactivat …
Lung directed antibody gene transfer confers protection against SARS-CoV-2 infection.
Du Y, Miah KM, Habib O, Meyer-Berg H, Conway CC, Viegas MA, Dean R, Satyapertiwi D, Zhao J, Wang Y, Temperton NJ, Gamlen TPE, Gill DR, Hyde SC. Du Y, et al. Among authors: gill dr. Thorax. 2022 Dec;77(12):1229-1236. doi: 10.1136/thoraxjnl-2021-217650. Epub 2022 Feb 14. Thorax. 2022. PMID: 35165144 Free PMC article.
If translated, the VIP approach could potentially offer a highly effective, long-term protection against COVID-19 for highly vulnerable populations; especially immune-deficient/senescent individuals, who fail to respond to conventional SARS-CoV-2 vaccines. ...
If translated, the VIP approach could potentially offer a highly effective, long-term protection against COVID-19 for highly vulnerab …
RNA-seq analysis of the human surfactant air-liquid interface culture reveals alveolar type II cell-like transcriptome.
Munis AM, Wright B, Jackson F, Lockstone H, Hyde SC, Green CM, Gill DR. Munis AM, et al. Among authors: gill dr. Mol Ther Methods Clin Dev. 2021 Nov 24;24:62-70. doi: 10.1016/j.omtm.2021.11.006. eCollection 2022 Mar 10. Mol Ther Methods Clin Dev. 2021. PMID: 34977273 Free PMC article.
Understanding pulmonary diseases requires robust culture models that are reproducible, sustainable in long-term culture, physiologically relevant, and suitable for assessment of therapeutic interventions. Primary human lung cells are physiologically relevant but cannot be …
Understanding pulmonary diseases requires robust culture models that are reproducible, sustainable in long-term culture, physiologica …
Genomic diversity of SARS-CoV-2 in Oxford during United Kingdom's first national lockdown.
Munis AM, Andersson M, Mobbs A, Hyde SC, Gill DR. Munis AM, et al. Among authors: gill dr. Sci Rep. 2021 Nov 2;11(1):21484. doi: 10.1038/s41598-021-01022-x. Sci Rep. 2021. PMID: 34728747 Free PMC article.
To avoid such issues and better understand the selection-based changes occurring in the SARS-CoV-2 genome, we utilized local isolates collected during the UK's first national lockdown whereby personal interactions, international and national travel were considerably restricted an …
To avoid such issues and better understand the selection-based changes occurring in the SARS-CoV-2 genome, we utilized local isolates collec …
A Comparison of Revision Rates for Osteoarthritis of Primary Reverse Total Shoulder Arthroplasty to Primary Anatomic Shoulder Arthroplasty with a Cemented All-polyethylene Glenoid: Analysis from the Australian Orthopaedic Association National Joint Replacement Registry.
Gill DRJ, Page BMedSci RS, Graves SE, Rainbird S, Hatton A. Gill DRJ, et al. Clin Orthop Relat Res. 2021 Oct 1;479(10):2216-2224. doi: 10.1097/CORR.0000000000001869. Clin Orthop Relat Res. 2021. PMID: 34180871 Free PMC article.
BACKGROUND: There has been decreased use of anatomic total shoulder arthroplasty (aTSA) because reverse TSA (rTSA) is increasingly being used for the same indications. Although short-term studies generally have not found survivorship differences between these implant desig …
BACKGROUND: There has been decreased use of anatomic total shoulder arthroplasty (aTSA) because reverse TSA (rTSA) is increasingly being use …
The safety profile of a cationic lipid-mediated cystic fibrosis gene transfer agent following repeated monthly aerosol administration to sheep.
Alton EW, Baker A, Baker E, Boyd AC, Cheng SH, Coles RL, Collie DD, Davidson H, Davies JC, Gill DR, Gordon C, Griesenbach U, Higgins T, Hyde SC, Innes JA, McCormick D, McGovern M, McLachlan G, Porteous DJ, Pringle I, Scheule RK, Shaw DJ, Smith S, Sumner-Jones SG, Tennant P, Vrettou C. Alton EW, et al. Among authors: gill dr. Biomaterials. 2013 Dec;34(38):10267-77. doi: 10.1016/j.biomaterials.2013.09.023. Epub 2013 Oct 3. Biomaterials. 2013. PMID: 24090839
The UK CF Gene Therapy Consortium is currently evaluating long-term repeated delivery of pGM169 complexed with the cationic lipid GL67A in a large Multidose Trial. ...
The UK CF Gene Therapy Consortium is currently evaluating long-term repeated delivery of pGM169 complexed with the cationic lipid GL6 …
Lack of repeat transduction by recombinant adeno-associated virus type 5/5 vectors in the mouse airway.
Sumner-Jones SG, Gill DR, Hyde SC. Sumner-Jones SG, et al. Among authors: gill dr. J Virol. 2007 Nov;81(22):12360-7. doi: 10.1128/JVI.01010-07. Epub 2007 Sep 12. J Virol. 2007. PMID: 17855531 Free PMC article.
While recombinant adeno-associated virus (rAAV) vectors promote long-term transgene expression in the lungs and other organs, the goal of correcting chronic inherited lung diseases such as cystic fibrosis with this type of viral gene transfer vector is limited by the requi …
While recombinant adeno-associated virus (rAAV) vectors promote long-term transgene expression in the lungs and other organs, the goa …
17 results