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RAGE engagement by SARS-CoV-2 enables monocyte infection and underlies COVID-19 severity.
Angioni R, Bonfanti M, Caporale N, Sánchez-Rodríguez R, Munari F, Savino A, Pasqualato S, Buratto D, Pagani I, Bertoldi N, Zanon C, Ferrari P, Ricciardelli E, Putaggio C, Ghezzi S, Elli F, Rotta L, Scardua A, Weber J, Cecatiello V, Iorio F, Zonta F, Cattelan AM, Vicenzi E, Vannini A, Molon B, Villa CE, Viola A, Testa G. Angioni R, et al. Among authors: ghezzi s. Cell Rep Med. 2023 Nov 21;4(11):101266. doi: 10.1016/j.xcrm.2023.101266. Epub 2023 Nov 8. Cell Rep Med. 2023. PMID: 37944530 Free PMC article.
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has fueled the COVID-19 pandemic with its enduring medical and socioeconomic challenges because of subsequent waves and long-term consequences of great concern. Here, we chart the molecular basis of …
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has fueled the COVID-19 pandemic with its enduring medical and so …
Long-term Clinical Outcome of Trastuzumab and Lapatinib for HER2-positive Metastatic Colorectal Cancer.
Tosi F, Sartore-Bianchi A, Lonardi S, Amatu A, Leone F, Ghezzi S, Martino C, Bencardino K, Bonazzina E, Bergamo F, Fenocchio E, Martinelli E, Troiani T, Siravegna G, Mauri G, Torri V, Marrapese G, Valtorta E, Cassingena A, Cappello G, Bonoldi E, Vanzulli A, Regge D, Ciardiello F, Zagonel V, Bardelli A, Trusolino L, Marsoni S, Siena S. Tosi F, et al. Among authors: ghezzi s. Clin Colorectal Cancer. 2020 Dec;19(4):256-262.e2. doi: 10.1016/j.clcc.2020.06.009. Epub 2020 Jun 27. Clin Colorectal Cancer. 2020. PMID: 32919890 Free article. Clinical Trial.
BACKGROUND: ERBB2 amplification occurs in 5% of RAS wild-type metastatic colorectal cancer (mCRC) and it has been shown to be a target for treatment with 2 HER2-directed combinations of trastuzumab and lapatinib or trastuzumab and pertuzumab. We present long-term clinical …
BACKGROUND: ERBB2 amplification occurs in 5% of RAS wild-type metastatic colorectal cancer (mCRC) and it has been shown to be a target for t …
Characterization of HIV-1 entry inhibitors with broad activity against R5 and X4 viral strains.
Sironi F, Malnati M, Mongelli N, Cozzi P, Guzzo C, Ghezzi S, Martínez-Romero C, García-Sastre A, Lusso P, Jabes D, Biswas P. Sironi F, et al. Among authors: ghezzi s. J Transl Med. 2015 Apr 2;13:107. doi: 10.1186/s12967-015-0461-9. J Transl Med. 2015. PMID: 25888743 Free PMC article.
BACKGROUND: Combined antiretroviral therapy has drastically reduced mortality and morbidity of HIV-infected individuals. Nevertheless long-term toxicity and appearance of viral resistance hampers the prolonged effectiveness of combination therapy, requiring a continuous in …
BACKGROUND: Combined antiretroviral therapy has drastically reduced mortality and morbidity of HIV-infected individuals. Nevertheless long- …
Identification of TRIM22 single nucleotide polymorphisms associated with loss of inhibition of HIV-1 transcription and advanced HIV-1 disease.
Ghezzi S, Galli L, Kajaste-Rudnitski A, Turrini F, Marelli S, Toniolo D, Casoli C, Riva A, Poli G, Castagna A, Vicenzi E. Ghezzi S, et al. AIDS. 2013 Sep 24;27(15):2335-44. doi: 10.1097/01.aids.0000432474.76873.5f. AIDS. 2013. PMID: 23921607
DESIGN: The allelic discrimination was determined in 182 HIV-1-negative and among HIV-1-positive individuals with advanced disease progression (advanced progressors; n = 57), normal progressors (n = 76), and long-term nonprogressors (LTNPs; n = 95). METHODS: Renilla lucife …
DESIGN: The allelic discrimination was determined in 182 HIV-1-negative and among HIV-1-positive individuals with advanced disease progressi …
Single-nucleotide polymorphism-defined class I and class III major histocompatibility complex genetic subregions contribute to natural long-term nonprogression in HIV infection.
Guergnon J, Dalmasso C, Broet P, Meyer L, Westrop SJ, Imami N, Vicenzi E, Morsica G, Tinelli M, Zanone Poma B, Goujard C, Potard V, Gotch FM, Casoli C, Cossarizza A, Macciardi F, Debré P, Delfraissy JF, Galli M, Autran B, Costagliola D, Poli G, Theodorou I, Riva A; GISHEAL Consortium. Guergnon J, et al. J Infect Dis. 2012 Mar 1;205(5):718-24. doi: 10.1093/infdis/jir833. Epub 2012 Jan 11. J Infect Dis. 2012. PMID: 22238471
We performed a genome-wide association study comparing a cohort of 144 human immunodeficiency virus (HIV type 1-infected, untreated white long-term nonprogressors (LTNPs) with a cohort of 605 HIV-1-infected white seroconverters. ...
We performed a genome-wide association study comparing a cohort of 144 human immunodeficiency virus (HIV type 1-infected, untreated white lo …
Nef-specific CD45RA+ CD8+ T cells secreting MIP-1beta but not IFN-gamma are associated with nonprogressive HIV-1 infection.
Dembek CJ, Kutscher S, Heltai S, Allgayer S, Biswas P, Ghezzi S, Vicenzi E, Hoffmann D, Reitmeir P, Tambussi G, Bogner JR, Lusso P, Stellbrink HJ, Santagostino E, Vollbrecht T, Goebel FD, Protzer U, Draenert R, Tinelli M, Poli G, Erfle V, Malnati M, Cosma A. Dembek CJ, et al. Among authors: ghezzi s. AIDS Res Ther. 2010 Jul 2;7:20. doi: 10.1186/1742-6405-7-20. AIDS Res Ther. 2010. PMID: 20598119 Free PMC article.
BACKGROUND: Long-term survival of HIV-1 infected individuals is usually achieved by continuous administration of combination antiretroviral therapy (ART). ...CONCLUSION: The novel antigen-specific CD45RA+ IFN-gammaneg MIP-1beta+ CD8+ T cell population represents a new cand …
BACKGROUND: Long-term survival of HIV-1 infected individuals is usually achieved by continuous administration of combination antiretr …
Hepatitis C virus (HCV) coinfection in a cohort of HIV positive long-term non-progressors: possible protective effect of infecting HCV genotype on HIV disease progression.
Morsica G, Bagaglio S, Ghezzi S, Lodrini C, Vicenzi E, Santagostino E, Gringeri A, Cusini M, Carminati G, Bianchi G, Galli L, Lazzarin A, Poli G. Morsica G, et al. Among authors: ghezzi s. J Clin Virol. 2007 Jun;39(2):82-6. doi: 10.1016/j.jcv.2007.03.007. Epub 2007 Apr 16. J Clin Virol. 2007. PMID: 17434339
We evaluated the potential impact of HCV coinfection and other determinants on HIV disease progression in a cohort of long-term non-progressors (LTNPs). STUDY DESIGN: We studied immunological and virological factors in a cohort of 49 LTNPs, 23 of whom progressed during the …
We evaluated the potential impact of HCV coinfection and other determinants on HIV disease progression in a cohort of long-term non-p …
Nef alleles from human immunodeficiency virus type 1-infected long-term-nonprogressor hemophiliacs with or without late disease progression are defective in enhancing virus replication and CD4 down-regulation.
Crotti A, Neri F, Corti D, Ghezzi S, Heltai S, Baur A, Poli G, Santagostino E, Vicenzi E. Crotti A, et al. Among authors: ghezzi s. J Virol. 2006 Nov;80(21):10663-74. doi: 10.1128/JVI.02621-05. Epub 2006 Aug 30. J Virol. 2006. PMID: 16943296 Free PMC article.
Infection with human immunodeficiency virus (HIV)-encoding defective nef variants may contribute to a relatively benign course of disease in a minority of long-term nonprogressors (LTNP). We have examined the functions of nef alleles from six individuals belonging to the s …
Infection with human immunodeficiency virus (HIV)-encoding defective nef variants may contribute to a relatively benign course of disease in …
14 results