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Preterm birth and sustained inflammation: consequences for the neonate.
Humberg A, Fortmann I, Siller B, Kopp MV, Herting E, Göpel W, Härtel C; German Neonatal Network, German Center for Lung Research and Priming Immunity at the beginning of life (PRIMAL) Consortium. Humberg A, et al. Semin Immunopathol. 2020 Aug;42(4):451-468. doi: 10.1007/s00281-020-00803-2. Epub 2020 Jul 13. Semin Immunopathol. 2020. PMID: 32661735 Free PMC article. Review.
This review will outline the (i) role of inflammation for short-term consequences of preterm birth and (ii) the effect of SI on organ development and long-term outcome....
This review will outline the (i) role of inflammation for short-term consequences of preterm birth and (ii) the effect of SI o …
Antifungal Treatment and Outcome in Very Low Birth Weight Infants: A Population-based Observational Study of the German Neonatal Network.
Fortmann I, Hartz A, Paul P, Pulzer F, Müller A, Böttger R, Proquitté H, Dawczynski K, Simon A, Rupp J, Herting E, Göpel W, Härtel C; German Neonatal Network. Fortmann I, et al. Pediatr Infect Dis J. 2018 Nov;37(11):1165-1171. doi: 10.1097/INF.0000000000002001. Pediatr Infect Dis J. 2018. PMID: 29601449
It was the aim of our study to determine the rate of exposure to empirical AFT in a large cohort of very low birth weight infants (VLBWI) of the German Neonatal Network and to address associated risks and outcomes. ...Univariate and logistic regression analyses were used t …
It was the aim of our study to determine the rate of exposure to empirical AFT in a large cohort of very low birth weight infants (VL …
Association of Administration of Surfactant Using Less Invasive Methods With Outcomes in Extremely Preterm Infants Less Than 27 Weeks of Gestation.
Härtel C, Herting E, Humberg A, Hanke K, Mehler K, Keller T, Mauer I, Frieauff E, Meyer S, Thome UH, Wieg C, Schmidtke S, Kribs A, Göpel W; German Neonatal Network. Härtel C, et al. JAMA Netw Open. 2022 Aug 1;5(8):e2225810. doi: 10.1001/jamanetworkopen.2022.25810. JAMA Netw Open. 2022. PMID: 35943742 Free PMC article.
RESULTS: A total of 6542 infants (3030 [46.3%] female and 3512 [53.7%] male; mean [SD] GA, 25.3 (1.1) weeks; mean [SD] birth weight, 715 [180] g) were analyzed; 2534 infants (38.7%) received LISA, which was most frequently given quasi-prophylactically during delivery room …
RESULTS: A total of 6542 infants (3030 [46.3%] female and 3512 [53.7%] male; mean [SD] GA, 25.3 (1.1) weeks; mean [SD] birth weight, …
Sleep problems in infancy and early school age in very preterm infants.
Neitmann J, Hanke K, Humberg A, Siller B, Spiegler J, Juhnke K, Gilmore J, Odendahl R, Herting E, Göpel W, Härtel C, Fortmann I; German Neonatal Network (GNN). Neitmann J, et al. Early Hum Dev. 2022 Oct;173:105656. doi: 10.1016/j.earlhumdev.2022.105656. Epub 2022 Aug 15. Early Hum Dev. 2022. PMID: 35987047
BACKGROUND: Sleep plays an important role for psychological and physical health, especially in infants at high risk for long-term neurodevelopmental impairment such as preterm infants. OBJECTIVE: Our study aimed at determining risk factors for long-term sleep impair …
BACKGROUND: Sleep plays an important role for psychological and physical health, especially in infants at high risk for long-term neu …
Delivery mode and intraventricular hemorrhage risk in very-low-birth-weight infants: Observational data of the German Neonatal Network.
Humberg A, Härtel C, Paul P, Hanke K, Bossung V, Hartz A, Fasel L, Rausch TK, Rody A, Herting E, Göpel W; German Neonatal Network (GNN). Humberg A, et al. Eur J Obstet Gynecol Reprod Biol. 2017 May;212:144-149. doi: 10.1016/j.ejogrb.2017.03.032. Epub 2017 Mar 22. Eur J Obstet Gynecol Reprod Biol. 2017. PMID: 28363188
BACKGROUND: Very-low-birth-weight infants (VLBWI) are frequently delivered by cesarean section (CS). ...STUDY DESIGN: A total cohort of 2203 singleton VLBWI with a birth weight <1500g and gestational age between 22 0/7 and 36 6/7 weeks born and discharged between …
BACKGROUND: Very-low-birth-weight infants (VLBWI) are frequently delivered by cesarean section (CS). ...STUDY DESIGN: A total cohort …
Epidemic microclusters of blood-culture proven sepsis in very-low-birth weight infants: experience of the German Neonatal Network.
Härtel C, Faust K, Avenarius S, Bohnhorst B, Emeis M, Gebauer C, Groneck P, Heitmann F, Hoehn T, Hubert M, Kribs A, Küster H, Laux R, Mögel M, Müller D, Olbertz D, Roll C, Siegel J, Stein A, Vochem M, Weller U, von der Wense A, Wieg C, Wintgens J, Hemmelmann C, Simon A, Herting E, Göpel W; German Neonatal Network (GNN). Härtel C, et al. PLoS One. 2012;7(6):e38304. doi: 10.1371/journal.pone.0038304. Epub 2012 Jun 29. PLoS One. 2012. PMID: 22768043 Free PMC article.
INTRODUCTION: We evaluated blood culture-proven sepsis episodes occurring in microclusters in very-low-birth-weight infants born in the German Neonatal Network (GNN) during 2009-2010. ...First patients in the cluster, their linked cases and sporadic sepsis events did not s …
INTRODUCTION: We evaluated blood culture-proven sepsis episodes occurring in microclusters in very-low-birth-weight infants born in t …
Association of ApoE Genotypes and Recovery From Intracerebral Hemorrhage in Very Low Birth Weight Infants.
Humberg A, Dzietko M, Schulz S, Felderhoff-Müser U, Hüning B, Stein A, Fortmann MI, Marissen J, Rausch TK, Herting E, Härtel C, Göpel W; German Neonatal Network (GNN). Humberg A, et al. Stroke. 2022 Feb;53(2):514-522. doi: 10.1161/STROKEAHA.120.033432. Epub 2021 Oct 8. Stroke. 2022. PMID: 34619984
METHODS: In this multicenter observational cohort study, very low birth weight (<1500 g, <32 weeks gestational age) children were studied for cerebral palsy (CP) after ultrasound diagnosed ICH stratified by APOE genotype. ...CONCLUSIONS: APOE-epsilon4 carriers have a …
METHODS: In this multicenter observational cohort study, very low birth weight (<1500 g, <32 weeks gestational age) children we …
ATP-binding cassette member A3 (E292V) gene mutation and pulmonary morbidity in very-low-birth-weight infants.
Härtel C, Felderhoff-Müser U, Gebauer C, Hoehn T, Kribs A, Laux R, Möller J, Segerer H, Teig N, von der Wense A, Wieg C, Stichtenoth G, Herting E, Göpel W; German Neonatal Network (GNN). Härtel C, et al. Acta Paediatr. 2012 Apr;101(4):380-3. doi: 10.1111/j.1651-2227.2011.02553.x. Epub 2012 Jan 9. Acta Paediatr. 2012. PMID: 22145626
AIM: ATP-binding cassette member A 3 (ABCA3) plays a critical role for the transport of surfactant phospholipids into the lamellar bodies of type II alveolar epithelial cells. Term infants carrying the E292V missense mutation of the gene encoding ABCA3 are likely to develo …
AIM: ATP-binding cassette member A 3 (ABCA3) plays a critical role for the transport of surfactant phospholipids into the lamellar bodies of …
Less invasive surfactant administration is associated with improved pulmonary outcomes in spontaneously breathing preterm infants.
Göpel W, Kribs A, Härtel C, Avenarius S, Teig N, Groneck P, Olbertz D, Roll C, Vochem M, Weller U, von der Wense A, Wieg C, Wintgens J, Preuss M, Ziegler A, Roth B, Herting E; German Neonatal Network (GNN). Göpel W, et al. Acta Paediatr. 2015 Mar;104(3):241-6. doi: 10.1111/apa.12883. Acta Paediatr. 2015. PMID: 25474712 Clinical Trial.
Additional large-scale randomised controlled trials are needed to assess the possible long-term benefits of LISA....
Additional large-scale randomised controlled trials are needed to assess the possible long-term benefits of LISA....
Recurrent Late-Onset Sepsis in Extremely Low Birth Weight Infants Is Associated with Motor Deficits in Early School Age.
Humberg A, Fortmann MI, Spiegler J, Rausch TK, Siller B, Silwedel C, Marissen J, Herting E, Göpel W, Härtel C; German Neonatal Network (GNN). Humberg A, et al. Neonatology. 2022;119(6):695-702. doi: 10.1159/000525709. Epub 2022 Nov 3. Neonatology. 2022. PMID: 36327925
INTRODUCTION: Sepsis is regarded as a risk factor for brain injury in preterm infants. We herein hypothesize that extremely low birth weight infants (ELBWI, birth weight <1,000 g) having survived recurrent blood culture-proven late-onset sepsis (LOS) episodes are …
INTRODUCTION: Sepsis is regarded as a risk factor for brain injury in preterm infants. We herein hypothesize that extremely low birth …
15 results