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Effects of sugars, fatty acids and amino acids on cytosolic and mitochondrial hydrogen peroxide release from liver cells.
Fang J, Zhang Y, Gerencser AA, Brand MD. Fang J, et al. Among authors: gerencser aa. Free Radic Biol Med. 2022 Aug 1;188:92-102. doi: 10.1016/j.freeradbiomed.2022.06.225. Epub 2022 Jun 16. Free Radic Biol Med. 2022. PMID: 35716827 Free PMC article.
Glucose supplementation also restored ATP production and mitochondrial NAD reduction level, suggesting that the increased rates of hydrogen peroxide release from the mitochondrial sites were driven by increases in the protonmotive force and the degree of reduction of the electron …
Glucose supplementation also restored ATP production and mitochondrial NAD reduction level, suggesting that the increased rates of hydrogen …
Mitochondrial bioenergetics and neuronal survival modelled in primary neuronal culture and isolated nerve terminals.
Nicholls DG, Brand MD, Gerencser AA. Nicholls DG, et al. Among authors: gerencser aa. J Bioenerg Biomembr. 2015 Apr;47(1-2):63-74. doi: 10.1007/s10863-014-9573-9. Epub 2014 Aug 30. J Bioenerg Biomembr. 2015. PMID: 25172197 Review.
Mitochondria play multiple roles in the maintenance of neuronal function under physiological and pathological conditions. In addition to ATP generation, they can act as major short-term calcium sinks and can both generate, and be damaged by, reactive oxygen species. ...
Mitochondria play multiple roles in the maintenance of neuronal function under physiological and pathological conditions. In addition to ATP …
Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure.
Choi SW, Gerencser AA, Nicholls DG. Choi SW, et al. Among authors: gerencser aa. J Neurochem. 2009 May;109(4):1179-91. doi: 10.1111/j.1471-4159.2009.06055.x. Epub 2009 Mar 23. J Neurochem. 2009. PMID: 19519782 Free PMC article.
Pre-synaptic mitochondrial dysfunction is implicated in a variety of neurodegenerative disorders, although there is no precise definition of the term 'dysfunction'. In this study, we test the hypothesis that partial restriction of electron transport through Complexes I and …
Pre-synaptic mitochondrial dysfunction is implicated in a variety of neurodegenerative disorders, although there is no precise definition of …
Mitochondrial swelling measurement in situ by optimized spatial filtering: astrocyte-neuron differences.
Gerencser AA, Doczi J, Töröcsik B, Bossy-Wetzel E, Adam-Vizi V. Gerencser AA, et al. Biophys J. 2008 Sep;95(5):2583-98. doi: 10.1529/biophysj.107.118620. Epub 2008 Apr 18. Biophys J. 2008. PMID: 18424491 Free PMC article.
We found that in situ astrocytic mitochondria swell upon short-term uncoupling or inhibition of oxidative phosphorylation, whereas such responses are absent in cultured cortical neurons....
We found that in situ astrocytic mitochondria swell upon short-term uncoupling or inhibition of oxidative phosphorylation, whereas su …