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Substance use disorder of equimolar oxygen-nitrous oxide mixture in French sickle-cell patients: results of the PHEDRE study.
Gérardin M, Rousselet M, Couec ML, Masseau A; PHEDRE Group; Aquizerate A, Authier N, Deheul S, Roussin A, Micallef J, Djezzar S; French Addictovigilance Network (FAN); Feuillet F, Jolliet P, Grall-Bronnec M, Victorri-Vigneau C. Gérardin M, et al. Orphanet J Rare Dis. 2024 Mar 18;19(1):124. doi: 10.1186/s13023-024-03133-w. Orphanet J Rare Dis. 2024. PMID: 38500184 Free PMC article.
BACKGROUND: In many countries, nitrous oxide is used in a gas mixture (EMONO) for short-term analgesia. Cases of addiction, with significant misuse, have been reported in hospitalized patients. ...
BACKGROUND: In many countries, nitrous oxide is used in a gas mixture (EMONO) for short-term analgesia. Cases of addiction, with sign …
Did the pattern of use of zolpidem change since the enforcement of a new prescription rule? A latent class analysis using the French health insurance database.
Istvan M, Rousselet M, Laforgue EJ, Guerlais M, Gérardin M, Jolliet P, Feuillet F, Victorri-Vigneau C. Istvan M, et al. Among authors: gerardin m. Expert Opin Drug Saf. 2022 Sep;21(9):1225-1234. doi: 10.1080/14740338.2022.2047930. Epub 2022 Mar 8. Expert Opin Drug Saf. 2022. PMID: 35255750
CONCLUSION: In conclusion, the regulatory change had a positive impact on the patterns of zolpidem use, but the impact should be reevaluated, because withdrawal can take a long time, especially in long-term users. TRIAL REGISTRATION: The study was registered at www.clinica …
CONCLUSION: In conclusion, the regulatory change had a positive impact on the patterns of zolpidem use, but the impact should be reevaluated …
Very early glucose tolerance abnormalities in children with cystic fibrosis.
Blanquer M, Clainche LL, Bismuth E, Storey C, Gerardin M, Houdouin V. Blanquer M, et al. Among authors: gerardin m. J Cyst Fibros. 2021 Sep;20(5):792-795. doi: 10.1016/j.jcf.2021.08.001. Epub 2021 Aug 17. J Cyst Fibros. 2021. PMID: 34417145 Free article.
We report three infants with abnormal glucose tolerance, beginning under the age of one year, including two cases of very early diabetes which started before the age of six months. None of our patients required long-term insulin treatment, and glycaemia spontaneously impro …
We report three infants with abnormal glucose tolerance, beginning under the age of one year, including two cases of very early diabetes whi …
Rapid Improvement after Starting Elexacaftor-Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and Advanced Pulmonary Disease.
Burgel PR, Durieu I, Chiron R, Ramel S, Danner-Boucher I, Prevotat A, Grenet D, Marguet C, Reynaud-Gaubert M, Macey J, Mely L, Fanton A, Quetant S, Lemonnier L, Paillasseur JL, Da Silva J, Martin C; French Cystic Fibrosis Reference Network Study Group. Burgel PR, et al. Am J Respir Crit Care Med. 2021 Jul 1;204(1):64-73. doi: 10.1164/rccm.202011-4153OC. Am J Respir Crit Care Med. 2021. PMID: 33600738

The mean (95% confidence interval) absolute increase in the ppFEV(1) was +15.1 (+13.8 to +16.4; P < 0.0001), and the mean (95% confidence interval) in weight was +4.2 kg (+3.9 to +4.6; P < 0.0001). The number of patients requiring long-term oxygen, noninvasive ventil

…

The mean (95% confidence interval) absolute increase in the ppFEV(1) was +15.1 (+13.8 to +16.4; P < 0.0001), and the mean (95% confidence

…
Change in the regulatory framework for zolpidem: What is the impact on the landscape of the prescription of sedative medications? The French national ZORRO study.
Istvan M, Caillet P, Rousselet M, Guerlais M, Laforgue EJ, Gérardin M, Jolliet P, Feuillet F, Victorri-Vigneau C. Istvan M, et al. Among authors: gerardin m. Br J Clin Pharmacol. 2021 Aug;87(8):3310-3319. doi: 10.1111/bcp.14753. Epub 2021 Feb 20. Br J Clin Pharmacol. 2021. PMID: 33506976 Free article.
All patients aged over 18 years old who were long-term users (at least 3 months) before the measure were enacted. We analysed the reimbursement trajectories of zolpidem, zopiclone, benzodiazepines and antihistamines (hydroxyzine and alimemazine) up to 2 years after the mea …
All patients aged over 18 years old who were long-term users (at least 3 months) before the measure were enacted. We analysed the rei …
Illicit drugs or medicines taken by parachuting.
Daveluy A, Géniaux H, Eiden C, Boucher A, Chenaf C, Deheul S, Spadari M, Gérardin M, Miremont-Salamé G, Haramburu F; French Network of Addictovigilance Centres. Daveluy A, et al. Among authors: gerardin m. Fundam Clin Pharmacol. 2016 Apr;30(2):185-90. doi: 10.1111/fcp.12172. Epub 2015 Dec 23. Fundam Clin Pharmacol. 2016. PMID: 26609911
The wrappers were a cigarette paper (nine cases) and in one case plastic package; in the other cases, the term of parachute was used without further details. The reason for use was not explained in the majority of cases; two patients indicated using a parachute for faster …
The wrappers were a cigarette paper (nine cases) and in one case plastic package; in the other cases, the term of parachute was used …
Dependence on prescription benzodiazepines and Z-drugs among young to middle-aged patients in France.
Guerlais M, Grall-Bronnec M, Feuillet F, Gérardin M, Jolliet P, Victorri-Vigneau C. Guerlais M, et al. Among authors: gerardin m. Subst Use Misuse. 2015 Feb;50(3):320-7. doi: 10.3109/10826084.2014.980952. Epub 2014 Dec 4. Subst Use Misuse. 2015. PMID: 25474727
A two factor concept of dependence could be identified according to the PCA: one axis with items of "tolerance" and "long term administration or higher doses", and a second axis with "concerned by treatment" and "somatic consequences". ...
A two factor concept of dependence could be identified according to the PCA: one axis with items of "tolerance" and "long term admini …
Clinical outcome of cystic fibrosis presenting with or without meconium ileus: a matched cohort study.
Munck A, Gérardin M, Alberti C, Ajzenman C, Lebourgeois M, Aigrain Y, Navarro J. Munck A, et al. Among authors: gerardin m. J Pediatr Surg. 2006 Sep;41(9):1556-60. doi: 10.1016/j.jpedsurg.2006.05.014. J Pediatr Surg. 2006. PMID: 16952591
OBJECTIVE: This matched case-control study compared the nutritional and the pulmonary long-term outcomes of cystic fibrosis (CF) patients presenting a history of meconium ileus (MI) with early-diagnosed symptomatic CF without MI (non-MI). MATERIAL AND METHOD: Twenty-six pa …
OBJECTIVE: This matched case-control study compared the nutritional and the pulmonary long-term outcomes of cystic fibrosis (CF) pati …
Follow-up of 452 totally implantable vascular devices in cystic fibrosis patients.
Munck A, Malbezin S, Bloch J, Gerardin M, Lebourgeois M, Derelle J, Bremont F, Sermet I, Munck MR, Navarro J. Munck A, et al. Among authors: gerardin m. Eur Respir J. 2004 Mar;23(3):430-4. doi: 10.1183/09031936.04.00052504. Eur Respir J. 2004. PMID: 15065834 Free article.
The mean functional time per device was 32 +/- 25 months. Long-term complications occurred with 188 devices (42%); they consisted mainly of occlusion (21%, requiring removal in 77%), infection (9.3%, requiring removal in 851%; septicaemia in 7.3%; rate 0.3 per 1,000 days, …
The mean functional time per device was 32 +/- 25 months. Long-term complications occurred with 188 devices (42%); they consisted mai …