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Chromatin accessibility and H3K9me3 landscapes reveal long-term epigenetic effects of fetal-neonatal iron deficiency in rat hippocampus.
Liu SX, Ramakrishnan A, Shen L, Gewirtz JC, Georgieff MK, Tran PV. Liu SX, et al. Among authors: georgieff mk. BMC Genomics. 2024 Mar 21;25(1):301. doi: 10.1186/s12864-024-10230-4. BMC Genomics. 2024. PMID: 38515015 Free PMC article.
BACKGROUND: Iron deficiency (ID) during the fetal-neonatal period results in long-term neurodevelopmental impairments associated with pervasive hippocampal gene dysregulation. ...CONCLUSIONS: This study reveals genome-wide, stable epigenetic changes and epigenetically modi …
BACKGROUND: Iron deficiency (ID) during the fetal-neonatal period results in long-term neurodevelopmental impairments associated with …
Identification of Genes Responding to Iron or Choline Treatment for Early-Life Iron Deficiency in the Male Rat Hippocampal Transcriptomes.
Liu SX, Calixto Mancipe N, Gisslen T, Georgieff MK, Tran PV. Liu SX, et al. Among authors: georgieff mk. J Nutr. 2024 Apr;154(4):1141-1152. doi: 10.1016/j.tjnut.2024.02.021. Epub 2024 Feb 24. J Nutr. 2024. PMID: 38408730
BACKGROUND: Developmental iron deficiency (ID) is associated with long-term cognitive and affective behavioral impairments in humans. Preclinical studies have shown that developmental ID has short- and long-term effects on gene regulation. Prenatal choline supplemen …
BACKGROUND: Developmental iron deficiency (ID) is associated with long-term cognitive and affective behavioral impairments in humans. …
RAPIDIRON Trial follow-up study - the RAPIDIRON-KIDS Study: protocol of a prospective observational follow-up study.
Derman RJ, Bellad RB, Bellad MB, Bradford-Rogers J, Georgieff MK, Aghai ZH, Thind S, Auerbach M, Boelig R, Leiby BE, Short V, Yogeshkumar S, Charantimath US, Somannavar MS, Mallapur AA, Pol R, Ramadurg U, Sangavi R, Peerapur BV, Banu N, Patil PS, Patil AP, Roy S, Vastrad P, Wallace D, Shah H, Goudar SS. Derman RJ, et al. Among authors: georgieff mk. Trials. 2023 Dec 20;24(1):818. doi: 10.1186/s13063-023-07740-z. Trials. 2023. PMID: 38124098 Free PMC article.
When anemia occurs in pregnancy, it increases the risk of adverse maternal, fetal, and postnatal outcomes. It induces preterm births and low birth weight (LBW) deliveries, long-term neurodevelopmental sequelae, and an increased risk of earlier onset of postnatal iro …
When anemia occurs in pregnancy, it increases the risk of adverse maternal, fetal, and postnatal outcomes. It induces preterm births and low …
Anemia, Iron Supplementation, and the Brain.
Gisslen T, Rao R, Georgieff MK. Gisslen T, et al. Among authors: georgieff mk. Clin Perinatol. 2023 Dec;50(4):853-868. doi: 10.1016/j.clp.2023.07.009. Epub 2023 Aug 31. Clin Perinatol. 2023. PMID: 37866852 Review.
Studies of infants with postnatal iron deficiency and iron deficiency anemia clearly demonstrated negative effects on short-term and long-term brain development and function. Randomized interventional trials studied erythropoiesis-stimulating agents and hemoglobin-b …
Studies of infants with postnatal iron deficiency and iron deficiency anemia clearly demonstrated negative effects on short-term and …
The Interaction between Psychological Stress and Iron Status on Early-Life Neurodevelopmental Outcomes.
Reid BM, Georgieff MK. Reid BM, et al. Among authors: georgieff mk. Nutrients. 2023 Aug 30;15(17):3798. doi: 10.3390/nu15173798. Nutrients. 2023. PMID: 37686831 Free PMC article. Review.
This review presents evidence from animal and human studies demonstrating the possible connection and significant impact of poor iron status and psychological distress on neurocognitive development during pregnancy and the neonatal period, with implications for long-term c …
This review presents evidence from animal and human studies demonstrating the possible connection and significant impact of poor iron status …
Establishing Normative Values for Healthy Term Infant Feeding Performance: Neonatal Eating Assessment Tool-Mixed, Oral Feeding Scale, and Early Feeding Skills Assessment.
McGrattan KE, Mohr AH, Weikle E, Hernandez K, Walsh K, Park J, Ramel SE, Georgieff MK, Dietz K, Dahlstrom K, Lindsay J, Thoyre S. McGrattan KE, et al. Among authors: georgieff mk. Am J Speech Lang Pathol. 2023 Nov 6;32(6):2792-2801. doi: 10.1044/2023_AJSLP-22-00372. Epub 2023 Sep 8. Am J Speech Lang Pathol. 2023. PMID: 37682537
The aim of this investigation was to elucidate the characteristics of healthy term infant feeding performance using three commonly employed clinical assessments: Neonatal Eating Assessment Tool-Mixed (NeoEat-Mixed), Oral Feeding Scale, and Early Feeding Skills (EFS). ...Th …
The aim of this investigation was to elucidate the characteristics of healthy term infant feeding performance using three commonly em …
The importance of iron deficiency in pregnancy on fetal, neonatal, and infant neurodevelopmental outcomes.
Georgieff MK. Georgieff MK. Int J Gynaecol Obstet. 2023 Aug;162 Suppl 2(Suppl 2):83-88. doi: 10.1002/ijgo.14951. Int J Gynaecol Obstet. 2023. PMID: 37538010 Review.
This article reviews the dynamics of fetal iron metabolism, the role of iron in the developing fetal brain, the short- and long-term neurobehavioral consequences of fetal iron underloading, and the potential mechanisms that account for the long-term effects of fetal …
This article reviews the dynamics of fetal iron metabolism, the role of iron in the developing fetal brain, the short- and long-term …
Sex-Specific Effects of Early-Life Iron Deficiency and Prenatal Choline Treatment on Adult Rat Hippocampal Transcriptome.
Liu SX, Fredrickson TK, Calixto Mancipe N, Georgieff MK, Tran PV. Liu SX, et al. Among authors: georgieff mk. Nutrients. 2023 Mar 7;15(6):1316. doi: 10.3390/nu15061316. Nutrients. 2023. PMID: 36986048 Free PMC article.
BACKGROUND: Fetal-neonatal iron deficiency (ID) causes long-term neurocognitive and affective dysfunctions. Clinical and preclinical studies have shown that early-life ID produces sex-specific effects. ...
BACKGROUND: Fetal-neonatal iron deficiency (ID) causes long-term neurocognitive and affective dysfunctions. Clinical and preclinical …
Preterm infant body composition, working memory, and temperament.
Morris EE, Miller NC, Haapala JL, Georgieff MK, Ramel SE. Morris EE, et al. Among authors: georgieff mk. Infant Behav Dev. 2023 Feb;70:101808. doi: 10.1016/j.infbeh.2022.101808. Epub 2023 Jan 5. Infant Behav Dev. 2023. PMID: 36610269
This is a prospective observational pilot study recruiting 100 preterm (<33 weeks gestation), appropriate for gestational age, and very low birth weight infants, of which 49 infants met inclusion criteria. ...Associations between developmental tests and body composition …
This is a prospective observational pilot study recruiting 100 preterm (<33 weeks gestation), appropriate for gestational age, and very l …
Long-term follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder: corpus callosum white matter microstructure and neurocognitive outcomes.
Gimbel BA, Anthony ME, Ernst AM, Roediger DJ, de Water E, Eckerle JK, Boys CJ, Radke JP, Mueller BA, Fuglestad AJ, Zeisel SH, Georgieff MK, Wozniak JR. Gimbel BA, et al. Among authors: georgieff mk. J Neurodev Disord. 2022 Dec 16;14(1):59. doi: 10.1186/s11689-022-09470-w. J Neurodev Disord. 2022. PMID: 36526961 Free PMC article. Clinical Trial.
Early interventions targeting core neurocognitive deficits have the potential to confer long-term neurodevelopmental benefits. Time-targeted choline supplementation is one such intervention that has been shown to provide neurodevelopmental benefits that emerge with age dur …
Early interventions targeting core neurocognitive deficits have the potential to confer long-term neurodevelopmental benefits. Time-t …
117 results