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Early life exposure to queen mandibular pheromone mediates persistent transcriptional changes in the brain of honey bee foragers.
Peng T, Kennedy A, Wu Y, Foitzik S, Grüter C. Peng T, et al. J Exp Biol. 2024 May 10:jeb.247516. doi: 10.1242/jeb.247516. Online ahead of print. J Exp Biol. 2024. PMID: 38725404
The effects of the queen pheromone could have prolonged molecular impacts on workers that depend on an early sensitive period. We demonstrate that removal of QMP impacts long-term gene expression in the brain and antennae in foragers that were treated early in life …
The effects of the queen pheromone could have prolonged molecular impacts on workers that depend on an early sensitive period. We demonstrat …
A rapid return to normal: temporal gene expression patterns following cold exposure in the bumble bee Bombus impatiens.
Verble KM, Keaveny EC, Rahman SR, Jenny MJ, Dillon ME, Lozier JD. Verble KM, et al. J Exp Biol. 2024 May 1;227(9):jeb247040. doi: 10.1242/jeb.247040. Epub 2024 Apr 30. J Exp Biol. 2024. PMID: 38629177
The observed patterns of expression indicate a rapid recovery after chill coma, suggesting an acute differential transcriptional response during recovery from chill coma and return to baseline expression levels within an hour, with no long-term gene expression marke …
The observed patterns of expression indicate a rapid recovery after chill coma, suggesting an acute differential transcriptional response du …
Adeno-associated virus as a delivery vector for gene therapy of human diseases.
Wang JH, Gessler DJ, Zhan W, Gallagher TL, Gao G. Wang JH, et al. Signal Transduct Target Ther. 2024 Apr 3;9(1):78. doi: 10.1038/s41392-024-01780-w. Signal Transduct Target Ther. 2024. PMID: 38565561 Free PMC article. Review.
Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability to establish long-term gene expression in different tissues. Recombinant AAV (rAAV) has been engineered for enhanced specifici …
Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability …
PCR-Based Equine Gene Doping Test for the Australian Horseracing Industry.
Wilkin T, Hamilton NA, Cawley AT, Bhat S, Baoutina A. Wilkin T, et al. Int J Mol Sci. 2024 Feb 22;25(5):2570. doi: 10.3390/ijms25052570. Int J Mol Sci. 2024. PMID: 38473816 Free PMC article.
The term 'gene doping' is used to describe the use of any unauthorized gene therapy techniques. ...
The term 'gene doping' is used to describe the use of any unauthorized gene therapy techniques. ...
Optimised protocols to generate high titre lentiviral vectors using a novel transfection agent enabling extended HEK293T culture following transient transfection and suspension culture.
Suleman S, Fawaz S, Roberts T, Ellison S, Bigger B, Themis M. Suleman S, et al. J Virol Methods. 2024 Apr;325:114884. doi: 10.1016/j.jviromet.2024.114884. Epub 2024 Jan 11. J Virol Methods. 2024. PMID: 38218417 Free article.
These vectors can efficiently transduce a variety of cell types when dividing or non-dividing to provide permanent delivery and long-term gene expression. Demand for scalable manufacturing protocols able to generate enough high titre vector for widespread use of thi …
These vectors can efficiently transduce a variety of cell types when dividing or non-dividing to provide permanent delivery and long-term …
Meta-Analysis of Penetrance and Systematic Review on Transition to Disease in Genetic Hypertrophic Cardiomyopathy.
Topriceanu CC, Pereira AC, Moon JC, Captur G, Ho CY. Topriceanu CC, et al. Circulation. 2024 Jan 9;149(2):107-123. doi: 10.1161/CIRCULATIONAHA.123.065987. Epub 2023 Nov 6. Circulation. 2024. PMID: 37929589 Free PMC article.
In longitudinal family studies, the pooled phenotypic conversion across all genes was 15% over an average of 8 years of follow-up, starting from a mean of 16 years of age. However, short-term gene-specific phenotypic conversion varied between 12% for MYBPC3 and 23% …
In longitudinal family studies, the pooled phenotypic conversion across all genes was 15% over an average of 8 years of follow-up, starting …
Syndecan-4 Mediates the Cellular Entry of Adeno-Associated Virus 9.
Hudák A, Roach M, Pusztai D, Pettkó-Szandtner A, Letoha A, Szilák L, Azzouz M, Letoha T. Hudák A, et al. Int J Mol Sci. 2023 Feb 5;24(4):3141. doi: 10.3390/ijms24043141. Int J Mol Sci. 2023. PMID: 36834552 Free PMC article.
Due to their low pathogenicity, immunogenicity, and long-term gene expression, adeno-associated virus (AAV) vectors emerged as safe and efficient gene delivery tools, over-coming setbacks experienced with other viral gene delivery systems in early gene therapy trial …
Due to their low pathogenicity, immunogenicity, and long-term gene expression, adeno-associated virus (AAV) vectors emerged as …
Comparative Efficiency of Gene-Activated Matrices Based on Chitosan Hydrogel and PRP Impregnated with BMP2 Polyplexes for Bone Regeneration.
Nedorubova IA, Bukharova TB, Mokrousova VO, Khvorostina MA, Vasilyev AV, Nedorubov AA, Grigoriev TE, Zagoskin YD, Chvalun SN, Kutsev SI, Goldshtein DV. Nedorubova IA, et al. Int J Mol Sci. 2022 Nov 25;23(23):14720. doi: 10.3390/ijms232314720. Int J Mol Sci. 2022. PMID: 36499056 Free PMC article.
All gene-activated matrices showed transfecting ability and ensured long-term gene expression and the production of target proteins in vitro. ...
All gene-activated matrices showed transfecting ability and ensured long-term gene expression and the production of target pro …
Chronic Trazodone and Citalopram Treatments Increase Trophic Factor and Circadian Rhythm Gene Expression in Rat Brain Regions Relevant for Antidepressant Efficacy.
Carboni L, Rullo L, Caputi FF, Stamatakos S, Candeletti S, Romualdi P. Carboni L, et al. Int J Mol Sci. 2022 Nov 14;23(22):14041. doi: 10.3390/ijms232214041. Int J Mol Sci. 2022. PMID: 36430520 Free PMC article.
Antagonism to H1-histaminergic and alpha1-adrenergic receptors is responsible for a sleep-promoting action. We studied long-term gene expression modulations induced by chronic trazodone to investigate the molecular underpinning of trazodone efficacy. ...
Antagonism to H1-histaminergic and alpha1-adrenergic receptors is responsible for a sleep-promoting action. We studied long-term g …
Development of a high-yield, high-quality purification process for adeno-associated virus vectors that can be used in vivo without ultracentrifugation: Application to a lung endothelial cell-targeted adeno-associated virus.
Shiraishi Y, Adachi T, Cacicedo JM, Ido Y. Shiraishi Y, et al. FASEB J. 2022 Dec;36(12):e22653. doi: 10.1096/fj.202200840RR. FASEB J. 2022. PMID: 36374251
Recombinant adeno-associated viruses (rAAVs) are useful vectors for expressing genes of interest in vivo because of their low immunogenicity and long-term gene expression. Various mutations have been introduced in recent years and have enabled high-efficacy, stabili …
Recombinant adeno-associated viruses (rAAVs) are useful vectors for expressing genes of interest in vivo because of their low immunogenicity …
149 results