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Practical assessment of risk of VILI from ventilating power: a conceptual model.
Marini JJ, Thornton LT, Rocco PRM, Gattinoni L, Crooke PS. Marini JJ, et al. Among authors: gattinoni l. Crit Care. 2023 Apr 20;27(1):157. doi: 10.1186/s13054-023-04406-9. Crit Care. 2023. PMID: 37081517 Free PMC article. Review.
For this purpose, driving pressure (DP) and end-inspiratory static 'plateau' pressure ([Formula: see text]) of the tidal cycle are unquestionably useful but lack key information relating to associated volume changes and cumulative strain. 'Mechanical power', a clinical term …
For this purpose, driving pressure (DP) and end-inspiratory static 'plateau' pressure ([Formula: see text]) of the tidal cycle are unquestio …
Long term feasibility of ultraprotective lung ventilation with low-flow extracorporeal carbon dioxide removal in ARDS patients.
Chiumello D, Pozzi T, Mereto E, Fratti I, Chiodaroli E, Gattinoni L, Coppola S. Chiumello D, et al. Among authors: gattinoni l. J Crit Care. 2022 Oct;71:154092. doi: 10.1016/j.jcrc.2022.154092. Epub 2022 Jun 14. J Crit Care. 2022. PMID: 35714453
PURPOSE: To explore the feasibility of long-term application of ultraprotective ventilation with low flow ECCO(2)R support in moderate-severe ARDS patients and the reduction of mechanical power (MP) compared to lung protective ventilation. ...
PURPOSE: To explore the feasibility of long-term application of ultraprotective ventilation with low flow ECCO(2)R support in moderat …
The physiological underpinnings of life-saving respiratory support.
Telias I, Brochard LJ, Gattarello S, Wunsch H, Junhasavasdikul D, Bosma KJ, Camporota L, Brodie D, Marini JJ, Slutsky AS, Gattinoni L. Telias I, et al. Among authors: gattinoni l. Intensive Care Med. 2022 Oct;48(10):1274-1286. doi: 10.1007/s00134-022-06749-3. Epub 2022 Jun 12. Intensive Care Med. 2022. PMID: 35690953 Free PMC article. Review.
., immobilization, sleep disruption) can have devastating long-term effects. Increasing awareness and understanding of these mechanisms of injury has led to a change in the philosophy of care with a shift from aiming to normalize gases toward minimizing harm. ...
., immobilization, sleep disruption) can have devastating long-term effects. Increasing awareness and understanding of these mechanis …
BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells.
Yao C, Lou G, Sun HW, Zhu Z, Sun Y, Chen Z, Chauss D, Moseman EA, Cheng J, D'Antonio MA, Shi W, Shi J, Kometani K, Kurosaki T, Wherry EJ, Afzali B, Gattinoni L, Zhu Y, McGavern DB, O'Shea JJ, Schwartzberg PL, Wu T. Yao C, et al. Among authors: gattinoni l. Nat Immunol. 2021 Mar;22(3):370-380. doi: 10.1038/s41590-021-00868-7. Epub 2021 Feb 11. Nat Immunol. 2021. PMID: 33574619 Free PMC article.
During chronic infection and cancer, a self-renewing CD8(+) T cell subset maintains long-term immunity and is critical to the effectiveness of immunotherapy. ...
During chronic infection and cancer, a self-renewing CD8(+) T cell subset maintains long-term immunity and is critical to the effecti …
Monitoring lung impedance changes during long-term ventilator-induced lung injury ventilation using electrical impedance tomography.
Hahn G, Niewenhuys J, Just A, Tonetti T, Behnemann T, Rapetti F, Collino F, Vasques F, Maiolo G, Romitti F, Gattinoni L, Quintel M, Moerer O. Hahn G, et al. Among authors: gattinoni l. Physiol Meas. 2020 Oct 9;41(9):095011. doi: 10.1088/1361-6579/abb1fb. Physiol Meas. 2020. PMID: 33035199
OBJECTIVE: The target of this methodological evaluation was the feasibility of long-term monitoring of changes in lung conditions by time-difference electrical impedance tomography (tdEIT). ...This justified the usage of tdEIT with its superior local resolution compared to …
OBJECTIVE: The target of this methodological evaluation was the feasibility of long-term monitoring of changes in lung conditions by …
Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection.
Yao C, Sun HW, Lacey NE, Ji Y, Moseman EA, Shih HY, Heuston EF, Kirby M, Anderson S, Cheng J, Khan O, Handon R, Reilley J, Fioravanti J, Hu J, Gossa S, Wherry EJ, Gattinoni L, McGavern DB, O'Shea JJ, Schwartzberg PL, Wu T. Yao C, et al. Among authors: gattinoni l. Nat Immunol. 2019 Jul;20(7):890-901. doi: 10.1038/s41590-019-0403-4. Epub 2019 Jun 17. Nat Immunol. 2019. PMID: 31209400 Free PMC article.
Progenitor-like CD8(+) T cells mediate long-term immunity to chronic infection and cancer and respond potently to immune checkpoint blockade. ...Moreover, thymocyte selection-associated high mobility group box protein TOX (TOX) promoted the persistence of antiviral CD8(+) …
Progenitor-like CD8(+) T cells mediate long-term immunity to chronic infection and cancer and respond potently to immune checkpoint b …
Quality of Life and Lung Function in Survivors of Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome.
Grasselli G, Scaravilli V, Tubiolo D, Russo R, Crimella F, Bichi F, Morlacchi LC, Scotti E, Patrini L, Gattinoni L, Pesenti A, Chiumello D. Grasselli G, et al. Among authors: gattinoni l. Anesthesiology. 2019 Apr;130(4):572-580. doi: 10.1097/ALN.0000000000002624. Anesthesiology. 2019. PMID: 30875355 Free article.
BACKGROUND: Survivors of acute respiratory distress syndrome (ARDS) have long-term impairment of pulmonary function and health-related quality of life, but little is known of outcomes of ARDS survivors treated with extracorporeal membrane oxygenation. The aim of this study …
BACKGROUND: Survivors of acute respiratory distress syndrome (ARDS) have long-term impairment of pulmonary function and health-relate …
Antioxidant metabolism regulates CD8+ T memory stem cell formation and antitumor immunity.
Pilipow K, Scamardella E, Puccio S, Gautam S, De Paoli F, Mazza EM, De Simone G, Polletti S, Buccilli M, Zanon V, Di Lucia P, Iannacone M, Gattinoni L, Lugli E. Pilipow K, et al. Among authors: gattinoni l. JCI Insight. 2018 Sep 20;3(18):e122299. doi: 10.1172/jci.insight.122299. eCollection 2018 Sep 20. JCI Insight. 2018. PMID: 30232291 Free PMC article.
Adoptive T cell transfer (ACT) immunotherapy benefits from early differentiated stem cell memory T (Tscm) cells capable of persisting in the long term and generating potent antitumor effectors. Due to their paucity ex vivo, Tscm cells can be derived from naive precursors, …
Adoptive T cell transfer (ACT) immunotherapy benefits from early differentiated stem cell memory T (Tscm) cells capable of persisting in the …
Extracorporeal organ support (ECOS) in critical illness and acute kidney injury: from native to artificial organ crosstalk.
Husain-Syed F, Ricci Z, Brodie D, Vincent JL, Ranieri VM, Slutsky AS, Taccone FS, Gattinoni L, Ronco C. Husain-Syed F, et al. Among authors: gattinoni l. Intensive Care Med. 2018 Sep;44(9):1447-1459. doi: 10.1007/s00134-018-5329-z. Epub 2018 Jul 24. Intensive Care Med. 2018. PMID: 30043276 Review.
In this review, we describe the patterns of organ crosstalk between the native and artificial organs, the incidence of AKI and need for RRT and associated mortality after extracorporeal organ support (ECOS) therapy, including the potential short- and long-term advantages a …
In this review, we describe the patterns of organ crosstalk between the native and artificial organs, the incidence of AKI and need for RRT …
43 results