Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation.
Alexander DC, Corman T, Mendoza M, Glass A, Belity T, Wu R, Campbell RR, Han J, Keiser AA, Winkler J, Wood MA, Kim T, Garcia BA, Cohen H, Mews P, Egervari G, Berger SL.
Alexander DC, et al. Among authors: garcia ba.
Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2114758119. doi: 10.1073/pnas.2114758119. Epub 2022 Aug 3.
Proc Natl Acad Sci U S A. 2022.
PMID: 35921439
Free PMC article.
Histone acetylation is a key component in the consolidation of long-term fear memories. Histone acetylation is fueled by acetyl-coenzyme A (acetyl-CoA), and recently, nuclear-localized metabolic enzymes that produce this metabolite have emerged as direct and local regulato …
Histone acetylation is a key component in the consolidation of long-term fear memories. Histone acetylation is fueled by acetyl-coenz …