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Sepsis-related coagulopathy treatment based on the disseminated intravascular coagulation diagnostic criteria: a post-hoc analysis of a prospective multicenter observational study.
Wada T, Yamakawa K, Kabata D, Abe T, Fujishima S, Kushimoto S, Mayumi T, Ogura H, Saitoh D, Shiraishi A, Otomo Y, Gando S; JAAM FORECAST Group. Wada T, et al. Among authors: gando s. J Intensive Care. 2023 Mar 5;11(1):8. doi: 10.1186/s40560-023-00656-5. J Intensive Care. 2023. PMID: 36872342 Free PMC article.
We examined the association of patient outcomes, including organ dysfunction and in-hospital mortality, with the DIC score and prothrombin time-international normalized ratio (PT-INR), one of the components of the DIC score, using multivariable regression models including the cro …
We examined the association of patient outcomes, including organ dysfunction and in-hospital mortality, with the DIC score and prothrombin t …
Association of antithrombin with development of trauma-induced disseminated intravascular coagulation and outcomes.
Wada T, Shiraishi A, Gando S, Kabata D, Yamakawa K, Fujishima S, Saitoh D, Kushimoto S, Ogura H, Abe T, Mayumi T, Otomo Y. Wada T, et al. Among authors: gando s. Front Immunol. 2022 Dec 9;13:1026163. doi: 10.3389/fimmu.2022.1026163. eCollection 2022. Front Immunol. 2022. PMID: 36569855 Free PMC article.
Antithrombin activity at 3 h showed good predictive performance for in-hospital mortality, and a multivariable Cox proportional-hazard regression model with a cross-product term between the antithrombin and DIC showed that the in-hospital mortality in patients with DIC inc …
Antithrombin activity at 3 h showed good predictive performance for in-hospital mortality, and a multivariable Cox proportional-hazard regre …
Association of frailty on treatment outcomes among patients with suspected infection treated at emergency departments.
Ishikawa S, Miyagawa I, Kusanaga M, Abe T, Shiraishi A, Fujishima S, Ogura H, Saitoh D, Kushimoto S, Shiino Y, Hifumi T, Otomo Y, Okamoto K, Kotani J, Sakamoto Y, Sasaki J, Shiraishi SI, Takuma K, Hagiwara A, Yamakawa K, Takeyama N, Gando S, Mayumi T. Ishikawa S, et al. Among authors: gando s. Eur J Emerg Med. 2021 Aug 1;28(4):285-291. doi: 10.1097/MEJ.0000000000000788. Eur J Emerg Med. 2021. PMID: 34187992
The CFS score was associated with an increased risk of 28-day mortality and with a higher likelihood of long-term hospital stay and short-term VFDs and ICUFDs. Multivariate logistic regression analysis indicated that the CFS score was a predictor of 28-day mortality …
The CFS score was associated with an increased risk of 28-day mortality and with a higher likelihood of long-term hospital stay and s …
Identifying Septic Shock Populations Benefitting From Polymyxin B Hemoperfusion: A Prospective Cohort Study Incorporating a Restricted Cubic Spline Regression Model.
Nakata H, Yamakawa K, Kabata D, Umemura Y, Ogura H, Gando S, Shintani A, Shiraishi A, Saitoh D, Fujishima S, Mayumi T, Kushimoto S, Abe T, Shiino Y, Nakada TA, Tarui T, Hifumi T, Otomo Y, Okamoto K, Kotani J, Sakamoto Y, Sasaki J, Shiraishi SI, Takuma K, Tsuruta R, Hagiwara A, Masuno T, Takeyama N, Yamashita N, Ikeda H, Ueyama M, Fujimi S; Japanese Association for Acute Medicine (JAAM) Focused Outcomes Research in Emergency Care in Acute Respiratory Distress Syndrome, Sepsis and Trauma (FORECAST) Study Group. Nakata H, et al. Among authors: gando s. Shock. 2020 Nov;54(5):667-674. doi: 10.1097/SHK.0000000000001533. Shock. 2020. PMID: 32195922 Clinical Trial.
To identify best targets for PMX-HP, we developed a non-linear restricted cubic spline model including two-way interaction term (treatment Acute Physiology and Chronic Health Evaluation [APACHE] II score/Sequential Organ Failure Assessment [SOFA] score) and three-way inter …
To identify best targets for PMX-HP, we developed a non-linear restricted cubic spline model including two-way interaction term (trea …
Characteristics, management, and in-hospital mortality among patients with severe sepsis in intensive care units in Japan: the FORECAST study.
Abe T, Ogura H, Shiraishi A, Kushimoto S, Saitoh D, Fujishima S, Mayumi T, Shiino Y, Nakada TA, Tarui T, Hifumi T, Otomo Y, Okamoto K, Umemura Y, Kotani J, Sakamoto Y, Sasaki J, Shiraishi SI, Takuma K, Tsuruta R, Hagiwara A, Yamakawa K, Masuno T, Takeyama N, Yamashita N, Ikeda H, Ueyama M, Fujimi S, Gando S; JAAM FORECAST group. Abe T, et al. Among authors: gando s. Crit Care. 2018 Nov 22;22(1):322. doi: 10.1186/s13054-018-2186-7. Crit Care. 2018. PMID: 30466493 Free PMC article. Clinical Trial.
BACKGROUND: Sepsis is a leading cause of death and long-term disability in developed countries. A comprehensive report on the incidence, clinical characteristics, and evolving management of sepsis is important. ...
BACKGROUND: Sepsis is a leading cause of death and long-term disability in developed countries. A comprehensive report on the inciden …
Characteristics and outcomes of frail patients with suspected infection in intensive care units: a descriptive analysis from a multicenter cohort study.
Komori A, Abe T, Yamakawa K, Ogura H, Kushimoto S, Saitoh D, Fujishima S, Otomo Y, Kotani J, Sakamoto Y, Sasaki J, Shiino Y, Takeyama N, Tarui T, Tsuruta R, Nakada TA, Hifumi T, Iriyama H, Naito T, Gando S; JAAM SPICE Study Group. Komori A, et al. Among authors: gando s. BMC Geriatr. 2020 Nov 20;20(1):485. doi: 10.1186/s12877-020-01893-1. BMC Geriatr. 2020. PMID: 33218303 Free PMC article.
Kaplan-Meier survival curves showed little difference in the mortality rate during short-term follow-up. However, more vulnerable and frail patients died after 30-day than fit patients; this difference was not statistically significant (p = 0.25). ...
Kaplan-Meier survival curves showed little difference in the mortality rate during short-term follow-up. However, more vulnerable and …
Identifying Sepsis Populations Benefitting from Anticoagulant Therapy: A Prospective Cohort Study Incorporating a Restricted Cubic Spline Regression Model.
Yamakawa K, Gando S, Ogura H, Umemura Y, Kabata D, Shintani A, Shiraishi A, Saitoh D, Fujishima S, Mayumi T, Kushimoto S, Abe T, Shiino Y, Nakada TA, Tarui T, Hifumi T, Otomo Y, Okamoto K, Kotani J, Sakamoto Y, Sasaki J, Shiraishi SI, Takuma K, Tsuruta R, Hagiwara A, Masuno T, Takeyama N, Yamashita N, Ikeda H, Ueyama M, Fujimi S; Japanese Association for Acute Medicine (JAAM) Focused Outcomes Research in Emergency Care in Acute Respiratory Distress Syndrome, Sepsis Trauma (FORECAST) Study Group. Yamakawa K, et al. Among authors: gando s. Thromb Haemost. 2019 Nov;119(11):1740-1751. doi: 10.1055/s-0039-1693740. Epub 2019 Aug 13. Thromb Haemost. 2019. PMID: 31408900
Multivariable Cox proportional hazard regression analysis with nonlinear restricted cubic spline including a two-way interaction term (treatment each score) and three-way interaction term (treatment ISTH overt DIC score APACHE II score) was performed. RESULTS: The f …
Multivariable Cox proportional hazard regression analysis with nonlinear restricted cubic spline including a two-way interaction term …
Synbiotic therapy reduces the pathological gram-negative rods caused by an increased acetic acid concentration in the gut.
Hayakawa M, Asahara T, Ishitani T, Okamura A, Nomoto K, Gando S. Hayakawa M, et al. Among authors: gando s. Dig Dis Sci. 2012 Oct;57(10):2642-9. doi: 10.1007/s10620-012-2201-9. Epub 2012 May 11. Dig Dis Sci. 2012. PMID: 22576712 Free article. Clinical Trial.
AIMS: This study evaluated the changes in the gut flora and the intestinal environment after synbiotic therapy, and tried to clarify the mechanisms by which synbiotic therapy reduces pathological bacteria in the gut. METHODS: A total of 47 enteral feeding patients with long-te …
AIMS: This study evaluated the changes in the gut flora and the intestinal environment after synbiotic therapy, and tried to clarify the mec …
Systemic macrophage migration inhibitory factor release following hepatic resection.
Gando S, Nishihira J, Kobayashi S, Morimoto Y, Matsushita M, Kemmotsu O. Gando S, et al. Surg Today. 2001;31(7):605-9. doi: 10.1007/s005950170094. Surg Today. 2001. PMID: 11495155
We set out to determine the responses of macrophage migration inhibitory factor (MIF) to hepatic resection and investigate its role in predicting short-term postoperative morbidity and outcome. Blood samples from 29 patients undergoing hepatic resection and eight healthy v …
We set out to determine the responses of macrophage migration inhibitory factor (MIF) to hepatic resection and investigate its role in predi …