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Page 1
IL-33 mediates Pseudomonas induced airway fibrogenesis and is associated with CLAD.
Banday MM, Rao SB, Shankar S, Khanday MA, Finan J, O'Neill E, Coppolino A, Seyfang A, Kumar A, Rinewalt DE, Goldberg HJ, Woolley A, Mallidi HR, Visner G, Gaggar A, Patel KN, Sharma NS. Banday MM, et al. Among authors: gaggar a. J Heart Lung Transplant. 2023 Jan;42(1):53-63. doi: 10.1016/j.healun.2022.09.018. Epub 2022 Oct 5. J Heart Lung Transplant. 2023. PMID: 37014805 Free PMC article.
BACKGROUND: Long term outcomes of lung transplantation are impacted by the occurrence of chronic lung allograft dysfunction (CLAD). ...
BACKGROUND: Long term outcomes of lung transplantation are impacted by the occurrence of chronic lung allograft dysfunction (CLAD). . …
Transcriptional firing represses bactericidal activity in cystic fibrosis airway neutrophils.
Margaroli C, Moncada-Giraldo D, Gulick DA, Dobosh B, Giacalone VD, Forrest OA, Sun F, Gu C, Gaggar A, Kissick H, Wu R, Gibson G, Tirouvanziam R. Margaroli C, et al. Among authors: gaggar a. Cell Rep Med. 2021 Apr 8;2(4):100239. doi: 10.1016/j.xcrm.2021.100239. eCollection 2021 Apr 20. Cell Rep Med. 2021. PMID: 33948572 Free PMC article.
Treatment by the RNA polymerase II and III inhibitor alpha-amanitin restores the expression of key antimicrobial genes and increases the bactericidal capacity of CF airway neutrophils in vitro and in short-term sputum cultures ex vivo. Broadly, our findings show that neutr …
Treatment by the RNA polymerase II and III inhibitor alpha-amanitin restores the expression of key antimicrobial genes and increases the bac …
MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha.
Freeman A, Qiao L, Olave N, Rezonzew G, Gentle S, Halloran B, Pryhuber GS, Gaggar A, Tipple TE, Ambalavanan N, Lal CV. Freeman A, et al. Among authors: gaggar a. Respir Res. 2021 Feb 17;22(1):57. doi: 10.1186/s12931-021-01654-7. Respir Res. 2021. PMID: 33596914 Free PMC article.
METHODS: Here we report a prospective cohort study of extremely preterm neonates wherein infants diagnosed with severe BPD expressed increased airway miR-219-5p and decreased platelet derived growth factor receptor alpha (PDGFR-alpha), a target of mir-219-5p and a key regulator o …
METHODS: Here we report a prospective cohort study of extremely preterm neonates wherein infants diagnosed with severe BPD expressed increas …
Long-term Patient-Centered Outcomes in Cirrhotic Patients With Chronic Hepatitis C After Achieving Sustained Virologic Response.
Younossi ZM, Racila A, Muir A, Bourliere M, Mangia A, Esteban R, Zeuzem S, Colombo M, Manns M, Papatheodoridis GV, Buti M, Chokkalingam A, Gaggar A, Nader F, Younossi I, Henry L, Stepanova M. Younossi ZM, et al. Among authors: gaggar a. Clin Gastroenterol Hepatol. 2022 Feb;20(2):438-446. doi: 10.1016/j.cgh.2021.01.026. Epub 2021 Jan 22. Clin Gastroenterol Hepatol. 2022. PMID: 33493697 Clinical Trial.
BACKGROUND & AIMS: Achieving sustained virologic response (SVR) among patients with hepatitis C virus (HCV) leads to patient reported outcome (PRO) improvement. We aimed to assess the long-term post-SVR PRO trends in HCV patients with cirrhosis. METHODS: Patients with …
BACKGROUND & AIMS: Achieving sustained virologic response (SVR) among patients with hepatitis C virus (HCV) leads to patient reported ou …
Haemophilus influenzae persists in biofilm communities in a smoke-exposed ferret model of COPD.
Hunt BC, Stanford D, Xu X, Li J, Gaggar A, Rowe SM, Raju SV, Swords WE. Hunt BC, et al. Among authors: gaggar a. ERJ Open Res. 2020 Aug 11;6(3):00200-2020. doi: 10.1183/23120541.00200-2020. eCollection 2020 Jul. ERJ Open Res. 2020. PMID: 32802827 Free PMC article.
METHODS: In this study, we used a recently described ferret model for COPD, in which animals undergo chronic long-term exposure to cigarette smoke, to define host-pathogen interactions during COPD-related NTHi infections. ...
METHODS: In this study, we used a recently described ferret model for COPD, in which animals undergo chronic long-term exposure to ci …
Developing a sensitive HBV genotyping assay for HBV DNA suppressed patients using both DNA and RNA sequencing.
Liu Y, May L, Liu X, Martin R, Svarovskaia E, Gaggar A, Mo H, Feierbach B. Liu Y, et al. Among authors: gaggar a. J Med Virol. 2020 Dec;92(12):3420-3425. doi: 10.1002/jmv.26249. Epub 2020 Jul 11. J Med Virol. 2020. PMID: 32609910
Fifty-five serum samples from 55 chronic hepatitis B patients (HBeAg-, n = 20; HBeAg+, n = 35) across genotypes A to H with long-term nucleos(t)ide analogs (NAs) treatment were collected. All samples had HBV DNA less than 29 IU/mL. ...
Fifty-five serum samples from 55 chronic hepatitis B patients (HBeAg-, n = 20; HBeAg+, n = 35) across genotypes A to H with long-term …
Longitudinal analysis of serum microRNAs as predictors of cirrhosis regression during treatment of hepatitis B virus infection.
Orr C, Myers R, Li B, Jiang Z, Flaherty J, Gaggar A, Meissner EG. Orr C, et al. Among authors: gaggar a. Liver Int. 2020 Jul;40(7):1693-1700. doi: 10.1111/liv.14474. Epub 2020 May 2. Liver Int. 2020. PMID: 32301252 Free PMC article.
BACKGROUND AND AIMS: Most patients with cirrhosis induced by chronic HBV infection experience fibrosis regression after long-term antiviral treatment, while some remain cirrhotic. Fibrosis regression is associated with lower odds of developing hepatic decompensation and he …
BACKGROUND AND AIMS: Most patients with cirrhosis induced by chronic HBV infection experience fibrosis regression after long-term ant …
Predicting HBsAg clearance in genotype A chronic hepatitis B using HBsAg epitope profiling: A biomarker for functional cure.
Walsh R, Hammond R, Yuen L, Deerain J, O'Donnell T, Leary T, Cloherty G, Gaggar A, Kitrinos K, Subramanian M, Wong D, Locarnini S. Walsh R, et al. Among authors: gaggar a. Liver Int. 2019 Nov;39(11):2066-2076. doi: 10.1111/liv.14207. Epub 2019 Aug 21. Liver Int. 2019. PMID: 31379058 Clinical Trial.
The aim of this study was to map the HBsAg epitope profiles during long-term nucleos(t)ide analogue therapy in patients with genotype A CHB, in the context of HBsAg loss (SL)/seroconversion. ...
The aim of this study was to map the HBsAg epitope profiles during long-term nucleos(t)ide analogue therapy in patients with genotype …
Long-term Benefits of Sustained Virologic Response for Patient-Reported Outcomes in Patients With Chronic Hepatitis C Virus Infection.
Younossi ZM, Stepanova M, Racila A, Afendy A, Lawitz EJ, Schwabe C, Ruane PJ, Lalezari J, Reddy KR, Jacobson IM, Muir AJ, Gaggar A, Myers RP, Younossi I, Nader F. Younossi ZM, et al. Among authors: gaggar a. Clin Gastroenterol Hepatol. 2020 Feb;18(2):468-476.e11. doi: 10.1016/j.cgh.2019.07.047. Epub 2019 Jul 31. Clin Gastroenterol Hepatol. 2020. PMID: 31376493 Clinical Trial.
Ten-year efficacy and safety of tenofovir disoproxil fumarate treatment for chronic hepatitis B virus infection.
Marcellin P, Wong DK, Sievert W, Buggisch P, Petersen J, Flisiak R, Manns M, Kaita K, Krastev Z, Lee SS, Cathcart AL, Crans G, Op den Brouw M, Jump B, Gaggar A, Flaherty J, Buti M. Marcellin P, et al. Among authors: gaggar a. Liver Int. 2019 Oct;39(10):1868-1875. doi: 10.1111/liv.14155. Epub 2019 Jul 10. Liver Int. 2019. PMID: 31136052 Clinical Trial.
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