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CHM/REP1 cDNA delivery by lentiviral vectors provides functional expression of the transgene in the retinal pigment epithelium of choroideremia mice.
Tolmachova T, Tolmachov OE, Wavre-Shapton ST, Tracey-White D, Futter CE, Seabra MC. Tolmachova T, et al. J Gene Med. 2012 Mar;14(3):158-68. doi: 10.1002/jgm.1652. J Gene Med. 2012. PMID: 22228595
Subretinal injections of lentiviral vectors into mouse retinas resulted in efficient transduction of the RPE (30-35% of total RPE cells transduced after a 1-l injection), long-term expression for at least 6 months and a decrease in amount of unprenylated Rabs in the CHM RP …
Subretinal injections of lentiviral vectors into mouse retinas resulted in efficient transduction of the RPE (30-35% of total RPE cells tran …
Persistent episomal transgene expression in liver following delivery of a scaffold/matrix attachment region containing non-viral vector.
Argyros O, Wong SP, Niceta M, Waddington SN, Howe SJ, Coutelle C, Miller AD, Harbottle RP. Argyros O, et al. Gene Ther. 2008 Dec;15(24):1593-605. doi: 10.1038/gt.2008.113. Epub 2008 Jul 17. Gene Ther. 2008. PMID: 18633447
Long-term expression is demonstrated by monitoring the longitudinal luciferase expression profile for up to 6 months by means of in situ bioluminescent imaging. ...We conclude that the combination of a mammalian, tissue-specific promoter with the S/MAR element is sufficien …
Long-term expression is demonstrated by monitoring the longitudinal luciferase expression profile for up to 6 months by means of in s …
Delivery and long-term expression of a 135 kb LDLR genomic DNA locus in vivo by hydrodynamic tail vein injection.
Hibbitt OC, Harbottle RP, Waddington SN, Bursill CA, Coutelle C, Channon KM, Wade-Martins R. Hibbitt OC, et al. J Gene Med. 2007 Jun;9(6):488-97. doi: 10.1002/jgm.1041. J Gene Med. 2007. PMID: 17471590
Finally, BAC-end PCR, RT-PCR and immunohistochemistry demonstrate plasmid retention and long-term expression (4 months) of human LDLR in transfected hepatocytes. CONCLUSION: This is the first demonstration of somatic delivery and long-term expression of a genomic DN …
Finally, BAC-end PCR, RT-PCR and immunohistochemistry demonstrate plasmid retention and long-term expression (4 months) of human LDLR …
Clinically applicable procedure for gene delivery to fetal gut by ultrasound-guided gastric injection: toward prenatal prevention of early-onset intestinal diseases.
David AL, Peebles DM, Gregory L, Waddington SN, Themis M, Weisz B, Ruthe A, Lawrence L, Cook T, Rodeck CH, Coutelle C. David AL, et al. Hum Gene Ther. 2006 Jul;17(7):767-79. doi: 10.1089/hum.2006.17.767. Hum Gene Ther. 2006. PMID: 16839275
First-generation replication-deficient adenoviral vectors encoding the beta-galactosidase gene and transduction-enhancing agents were injected into the stomach of early-gestation fetal sheep (n = 8, 60 days of gestation; term, 145 days) under ultrasound guidance. Reporter …
First-generation replication-deficient adenoviral vectors encoding the beta-galactosidase gene and transduction-enhancing agents were inject …
Ultrasound-guided injection and occlusion of the trachea in fetal sheep.
David AL, Weisz B, Gregory L, Themis M, Cook T, Roubliova X, Deprest J, Coutelle C, Rodeck CH, Peebles DM. David AL, et al. Ultrasound Obstet Gynecol. 2006 Jul;28(1):82-8. doi: 10.1002/uog.2815. Ultrasound Obstet Gynecol. 2006. PMID: 16795134 Free article.
METHODS: Fetal sheep were operated on at a mean gestational age of 102 (range, 81-116) days (term = 145 days). Under ultrasound guidance, either a 20-G spinal (for vector delivery) or a 16-G Kellett (for placement of an occlusive balloon) needle was inserted via the fetal …
METHODS: Fetal sheep were operated on at a mean gestational age of 102 (range, 81-116) days (term = 145 days). Under ultrasound guida …