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Targeting B-Raf inhibitor resistant melanoma with novel cell penetrating peptide disrupters of PDE8A - C-Raf.
Blair CM, Walsh NM, Littman BH, Marcoux FW, Baillie GS. Blair CM, et al. BMC Cancer. 2019 Mar 25;19(1):266. doi: 10.1186/s12885-019-5489-4. BMC Cancer. 2019. PMID: 30909892 Free PMC article.
However, an un-met clinical need remains in B-Raf inhibitor resistant patients where first-generation B-Raf inhibitors provide only short-term disease control. In these cases, B-Raf inhibition leads to paradoxical activation of the C-Raf - MEK - ERK signalling pathway, fol …
However, an un-met clinical need remains in B-Raf inhibitor resistant patients where first-generation B-Raf inhibitors provide only short- …
Gravin orchestrates protein kinase A and β2-adrenergic receptor signaling critical for synaptic plasticity and memory.
Havekes R, Canton DA, Park AJ, Huang T, Nie T, Day JP, Guercio LA, Grimes Q, Luczak V, Gelman IH, Baillie GS, Scott JD, Abel T. Havekes R, et al. J Neurosci. 2012 Dec 12;32(50):18137-49. doi: 10.1523/JNEUROSCI.3612-12.2012. J Neurosci. 2012. PMID: 23238728 Free PMC article.
Here, we show that mice lacking the alpha-isoform of gravin have deficits in PKA-dependent long-lasting forms of hippocampal synaptic plasticity including beta2-adrenergic receptor-mediated plasticity, and selective impairments of long-term memory storage. Furthermore, bot …
Here, we show that mice lacking the alpha-isoform of gravin have deficits in PKA-dependent long-lasting forms of hippocampal synaptic plasti …
Sleep deprivation impairs cAMP signalling in the hippocampus.
Vecsey CG, Baillie GS, Jaganath D, Havekes R, Daniels A, Wimmer M, Huang T, Brown KM, Li XY, Descalzi G, Kim SS, Chen T, Shang YZ, Zhuo M, Houslay MD, Abel T. Vecsey CG, et al. Nature. 2009 Oct 22;461(7267):1122-5. doi: 10.1038/nature08488. Nature. 2009. PMID: 19847264 Free PMC article.
Constitutive activation of the G-protein subunit Galphas within forebrain neurons causes PKA-dependent alterations in fear conditioning and cortical Arc mRNA expression.
Kelly MP, Cheung YF, Favilla C, Siegel SJ, Kanes SJ, Houslay MD, Abel T. Kelly MP, et al. Learn Mem. 2008 Jan 28;15(2):75-83. doi: 10.1101/lm.723708. Print 2008 Feb. Learn Mem. 2008. PMID: 18230676 Free PMC article.
Memory formation requires cAMP signaling; thus, this cascade has been of great interest in the search for cognitive enhancers. Given that medications are administered long-term, we determined the effects of chronically increasing cAMP synthesis in the brain by expressing a …
Memory formation requires cAMP signaling; thus, this cascade has been of great interest in the search for cognitive enhancers. Given that me …