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LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: a phase 1b, multicentre, double-blind, placebo-controlled, randomised, multiple-ascending dose trial.
Urva S, Coskun T, Loh MT, Du Y, Thomas MK, Gurbuz S, Haupt A, Benson CT, Hernandez-Illas M, D'Alessio DA, Milicevic Z. Urva S, et al. Among authors: gurbuz s. Lancet. 2022 Nov 26;400(10366):1869-1881. doi: 10.1016/S0140-6736(22)02033-5. Epub 2022 Oct 27. Lancet. 2022. PMID: 36354040 Clinical Trial.
BACKGROUND: Treating hyperglycaemia and obesity in individuals with type 2 diabetes using multi-receptor agonists can improve short-term and long-term outcomes. LY3437943 is a single peptide with agonist activity for glucagon, glucose-dependent insulinotropic polype …
BACKGROUND: Treating hyperglycaemia and obesity in individuals with type 2 diabetes using multi-receptor agonists can improve short-term
Effects of teriparatide in Chinese and Caucasian women with osteoporosis: bridging study on efficacy.
Xie Z, Chen Y, Gurbuz S, Zhang B, Li Y, Bai F, Chen Y. Xie Z, et al. Among authors: gurbuz s. Clin Interv Aging. 2019 May 27;14:959-968. doi: 10.2147/CIA.S181929. eCollection 2019. Clin Interv Aging. 2019. PMID: 31213783 Free PMC article. Clinical Trial.
OBJECTIVE: To bridge the efficacy and compare the safety of the 24-week teriparatide treatment in a Chinese osteoporosis study (NCT00414973) to a large international trial (FPT, NCT00670501) to determine whether long-term results from the international study were applicabl …
OBJECTIVE: To bridge the efficacy and compare the safety of the 24-week teriparatide treatment in a Chinese osteoporosis study (NCT00414973) …
Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis: Subgroup analysis of Latin American patients in the phase 3 randomized UNCOVER-3 study.
Valenzuela F, de la Cruz Fernandez C, Galimberti RL, Gürbüz S, McKean-Matthews M, Goncalves L, Romiti R. Valenzuela F, et al. Among authors: gurbuz s. Actas Dermosifiliogr. 2017 Jul-Aug;108(6):550-563. doi: 10.1016/j.ad.2017.02.005. Epub 2017 Mar 23. Actas Dermosifiliogr. 2017. PMID: 28342534 Free article. Clinical Trial. English, Spanish.
At week 12, patients maintaining efficacy response and adequate overall safety were assigned, at the discretion of the investigator, to long-term extension with ixekizumab Q4W. RESULTS: At week 12, Psoriasis Area and Severity Index (PASI) 100 scores were 0%, 20.0% (p=0.075 …
At week 12, patients maintaining efficacy response and adequate overall safety were assigned, at the discretion of the investigator, to long …
Effects of oral care with glutamine in preventing ventilator-associated pneumonia in neurosurgical intensive care unit patients.
Kaya H, Turan Y, Tunalı Y, Aydın GÖ, Yüce N, Gürbüz Ş, Tosun K. Kaya H, et al. Among authors: gurbuz s. Appl Nurs Res. 2017 Feb;33:10-14. doi: 10.1016/j.apnr.2016.10.006. Epub 2016 Oct 12. Appl Nurs Res. 2017. PMID: 28096000
CONCLUSION: There was no significant difference in using 5% glutamine or 2% chlorhexidine gluconate solution for oral care for the prevention of ventilator-associated pneumonia. Similar studies with bigger sample size and longer term should be conducted for better results. …
CONCLUSION: There was no significant difference in using 5% glutamine or 2% chlorhexidine gluconate solution for oral care for the preventio …