Anti-SARS-CoV-2 T-stem cell memory persists in ocrelizumab-treated MS patients.
Guerrera G, Mandelli A, Finardi A, Orrico M, D'Orso S, Picozza M, Noviello M, Beretta V, Bonetti B, Calabrese M, Marastoni D, De Rossi N, Capra R, Salvetti M, Buscarinu MC, Inglese M, Uccelli A, Moiola L, Raposo C, Muros-Le Rouzic E, Pedotti R, Filippi M, Bonini C, Battistini L, Borsellino G, Furlan R.
Guerrera G, et al. Among authors: furlan r.
Mult Scler. 2022 Oct;28(12):1937-1943. doi: 10.1177/13524585221102158. Epub 2022 Jun 20.
Mult Scler. 2022.
PMID: 35723265
Within naive AIM(+) CD4(+) and CD8(+) T-cells, we detected T memory stem cells, suggesting the acquisition of long-term memory. CONCLUSIONS: B-cell depletion using ocrelizumab does not impair the development of long-lasting anti-SARS-CoV-2 T-cell responses....
Within naive AIM(+) CD4(+) and CD8(+) T-cells, we detected T memory stem cells, suggesting the acquisition of long-term memory. CONCL …