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The alpha-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats.
Fukaya N, Mochizuki K, Tanaka Y, Kumazawa T, Jiuxin Z, Fuchigami M, Goda T. Fukaya N, et al. Among authors: fuchigami m. Eur J Pharmacol. 2009 Dec 10;624(1-3):51-7. doi: 10.1016/j.ejphar.2009.09.048. Epub 2009 Oct 7. Eur J Pharmacol. 2009. PMID: 19818342
The Otsuka Long-Evans Tokushima Fatty (OLETF) rat, an animal model of type 2 diabetes, exhibits obesity, hyperglycemia and hyperlipidemia, with late onset of chronic and slowly progressive hyperinsulinemia. In this study, we examined effects of long-term dietary supplement …
The Otsuka Long-Evans Tokushima Fatty (OLETF) rat, an animal model of type 2 diabetes, exhibits obesity, hyperglycemia and hyperlipidemia, w …
Long-term treatment with propagermanium suppresses atherosclerosis in WHHL rabbits.
Eto Y, Shimokawa H, Tanaka E, Morishige K, Fuchigami M, Ishiwata Y, Matsushima K, Takeshita A. Eto Y, et al. Among authors: fuchigami m. J Cardiovasc Pharmacol. 2003 Feb;41(2):171-7. doi: 10.1097/00005344-200302000-00004. J Cardiovasc Pharmacol. 2003. PMID: 12548076
Macrophage accumulation in the aorta was also evaluated by immunostaining. Long-term treatment with propagermanium did not affect the serum lipid profiles. ...A significant positive correlation was noted between macrophage staining-positive area and intimal lesions (p < …
Macrophage accumulation in the aorta was also evaluated by immunostaining. Long-term treatment with propagermanium did not affect the …