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Prevalence, risk factors and outcomes of cardiac disease in cystic fibrosis: a multinational retrospective cohort study.
Frost F, Nazareth D, Fauchier L, Wat D, Shelley J, Austin P, Walshaw MJ, Lip GYH. Frost F, et al. Eur Respir J. 2023 Oct 26;62(4):2300174. doi: 10.1183/13993003.00174-2023. Print 2023 Oct. Eur Respir J. 2023. PMID: 37474158 Free PMC article.
BACKGROUND: Although people living with cystic fibrosis (PwCF) often have some risk factors for cardiovascular disease, including diabetes and chronic inflammation, little is known about the long-term cardiac risk in this condition. We aimed to determine the characteristic …
BACKGROUND: Although people living with cystic fibrosis (PwCF) often have some risk factors for cardiovascular disease, including diabetes a …
The long-term effects of insulin use in incident cystic fibrosis-related diabetes: a target trial emulated using longitudinal national registry data.
Granger E, Keogh RH, Frost F. Granger E, et al. Among authors: frost f. ERJ Open Res. 2022 Nov 7;8(4):00170-2022. doi: 10.1183/23120541.00170-2022. eCollection 2022 Oct. ERJ Open Res. 2022. PMID: 36382232 Free PMC article.
However, there are scarce clinical trial data to support the use of insulin, and little is known about the long-term outcomes of treatment. The aim of this study was to compare the long-term impacts of insulin use versus non-use in CFRD. ...CONCLUSION: Using well-es …
However, there are scarce clinical trial data to support the use of insulin, and little is known about the long-term outcomes of trea …
Developing an ecological approach to physical activity promotion in adults with Cystic fibrosis.
Shelley J, Dawson EA, Boddy LM, Stewart CE, Frost F, Nazareth D, Walshaw MJ, Knowles ZR. Shelley J, et al. Among authors: frost f. PLoS One. 2022 Aug 1;17(8):e0272355. doi: 10.1371/journal.pone.0272355. eCollection 2022. PLoS One. 2022. PMID: 35914006 Free PMC article.
Increasing levels of habitual PA may be more feasible and result in greater compliance than conventional exercise training inventions which give little or no attention to long-term PA behaviour. Despite this there is limited research exploring perceptions of PA among adult …
Increasing levels of habitual PA may be more feasible and result in greater compliance than conventional exercise training inventions which …
Sustainability of locally driven centres for those affected by dementia: a protocol for the get real with meeting centres realist evaluation.
Morton T, Evans SB, Brooker D, Williamson T, Wong G, Tinelli M, Frost F, Bray J, Hullah N. Morton T, et al. Among authors: frost f. BMJ Open. 2022 May 2;12(5):e062697. doi: 10.1136/bmjopen-2022-062697. BMJ Open. 2022. PMID: 35501073 Free PMC article.
However, it is not understood how these communities can ensure they are putting in place strategies that will help them sustain in the longer term, beyond start-up phase. METHODS AND ANALYSIS: This realist evaluation aims to understand the factors affecting sustainability …
However, it is not understood how these communities can ensure they are putting in place strategies that will help them sustain in the longe …
Antibiotic therapy for chronic infection with <I>Burkholderia cepacia</I> complex in people with cystic fibrosis.
Frost F, Shaw M, Nazareth D. Frost F, et al. Cochrane Database Syst Rev. 2021 Dec 10;12(12):CD013079. doi: 10.1002/14651858.CD013079.pub3. Cochrane Database Syst Rev. 2021. PMID: 34889457 Free PMC article. Review.
OBJECTIVES: The objective of this review is to assess the effects of long-term oral and inhaled antibiotic therapy targeted against chronic BCC lung infections in people with CF. ...SELECTION CRITERIA: Randomised controlled trials (RCTs) of long-term antibiotic ther …
OBJECTIVES: The objective of this review is to assess the effects of long-term oral and inhaled antibiotic therapy targeted against c …
Continuous glucose monitoring systems for monitoring cystic fibrosis-related diabetes.
Toner A, McCloy A, Dyce P, Nazareth D, Frost F. Toner A, et al. Among authors: frost f. Cochrane Database Syst Rev. 2021 Nov 29;11(11):CD013755. doi: 10.1002/14651858.CD013755.pub2. Cochrane Database Syst Rev. 2021. PMID: 34844283 Free PMC article. Review.
Studies with a cross-over design, even with a washout period between intervention arms, are not eligible for inclusion due to the potential long-term impact of each of the interventions and the potential to compromise the outcomes of the second intervention. ...
Studies with a cross-over design, even with a washout period between intervention arms, are not eligible for inclusion due to the potential …
Long-term instability of the intestinal microbiome is associated with metabolic liver disease, low microbiota diversity, diabetes mellitus and impaired exocrine pancreatic function.
Frost F, Kacprowski T, Rühlemann M, Pietzner M, Bang C, Franke A, Nauck M, Völker U, Völzke H, Dörr M, Baumbach J, Sendler M, Schulz C, Mayerle J, Weiss FU, Homuth G, Lerch MM. Frost F, et al. Gut. 2021 Mar;70(3):522-530. doi: 10.1136/gutjnl-2020-322753. Epub 2020 Nov 9. Gut. 2021. PMID: 33168600 Free PMC article.
Conversely, factors or manifest diseases that determine the long-term stability or instability of the microbiome are largely unknown. ...
Conversely, factors or manifest diseases that determine the long-term stability or instability of the microbiome are largely unknown. …
Ivacaftor Is Associated with Reduced Lung Infection by Key Cystic Fibrosis Pathogens. A Cohort Study Using National Registry Data.
Frost FJ, Nazareth DS, Charman SC, Winstanley C, Walshaw MJ. Frost FJ, et al. Ann Am Thorac Soc. 2019 Nov;16(11):1375-1382. doi: 10.1513/AnnalsATS.201902-122OC. Ann Am Thorac Soc. 2019. PMID: 31319678
Rationale: Ivacaftor can greatly improve clinical outcomes in people with cystic fibrosis (CF) and has been shown to have in vitro antibacterial properties, yet the long-term microbiological outcomes of treatment are unknown.Objectives: To investigate changes in respirator …
Rationale: Ivacaftor can greatly improve clinical outcomes in people with cystic fibrosis (CF) and has been shown to have in vitro antibacte …
17 results