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Effects of serial radon spa therapy on pain and peripheral immune status in patients suffering from musculoskeletal disorders- results from a prospective, randomized, placebo-controlled trial.
Donaubauer AJ, Becker I, Klein G, Voll RE, Weikl L, Klieser M, Barzangi S, Zhou JG, Fietkau R, Gaipl US, Frey B. Donaubauer AJ, et al. Among authors: frey b. Front Immunol. 2024 Feb 6;15:1307769. doi: 10.3389/fimmu.2024.1307769. eCollection 2024. Front Immunol. 2024. PMID: 38380316 Free PMC article. Clinical Trial.
The dolorimetry resulted in a significantly higher exerted pressure strength in patients after radon spa (p<0.001), but not after warm water applications. During the long-term follow-up, both treatment modalities reduced pain to a similar degree and pain modulation was …
The dolorimetry resulted in a significantly higher exerted pressure strength in patients after radon spa (p<0.001), but not after warm wa …
Personalized relapse prediction in patients with major depressive disorder using digital biomarkers.
Vairavan S, Rashidisabet H, Li QS, Ness S, Morrison RL, Soares CN, Uher R, Frey BN, Lam RW, Kennedy SH, Trivedi M, Drevets WC, Narayan VA. Vairavan S, et al. Among authors: frey bn. Sci Rep. 2023 Oct 30;13(1):18596. doi: 10.1038/s41598-023-44592-8. Sci Rep. 2023. PMID: 37903878 Free PMC article.
Major depressive disorder (MDD) is a chronic illness wherein relapses contribute to significant patient morbidity and mortality. Near-term prediction of relapses in MDD patients has the potential to improve outcomes by helping implement a 'predict and preempt' paradigm in …
Major depressive disorder (MDD) is a chronic illness wherein relapses contribute to significant patient morbidity and mortality. Near-ter
Long-term mitigation of drought changes the functional potential and life-strategies of the forest soil microbiome involved in organic matter decomposition.
Hartmann M, Herzog C, Brunner I, Stierli B, Meyer F, Buchmann N, Frey B. Hartmann M, et al. Among authors: frey b. Front Microbiol. 2023 Sep 29;14:1267270. doi: 10.3389/fmicb.2023.1267270. eCollection 2023. Front Microbiol. 2023. PMID: 37840720 Free PMC article.
Using an inverse climate change field experiment in the central European Alps, we explored how long-term irrigation of a naturally drought-stressed pine forest altered the metabolic potential of the soil microbiome and its ability to decompose lignocellulolytic compounds a …
Using an inverse climate change field experiment in the central European Alps, we explored how long-term irrigation of a naturally dr …
A standardized workflow for long-term longitudinal actigraphy data processing using one year of continuous actigraphy from the CAN-BIND Wellness Monitoring Study.
Slyepchenko A, Uher R, Ho K, Hassel S, Matthews C, Lukus PK, Daros AR, Minarik A, Placenza F, Li QS, Rotzinger S, Parikh SV, Foster JA, Turecki G, Müller DJ, Taylor VH, Quilty LC, Milev R, Soares CN, Kennedy SH, Lam RW, Frey BN. Slyepchenko A, et al. Among authors: frey bn. Sci Rep. 2023 Sep 15;13(1):15300. doi: 10.1038/s41598-023-42138-6. Sci Rep. 2023. PMID: 37714910 Free PMC article.
Monitoring sleep and activity through wearable devices such as wrist-worn actigraphs has the potential for long-term measurement in the individual's own environment. Long periods of data collection require a complex approach, including standardized pre-processing and data …
Monitoring sleep and activity through wearable devices such as wrist-worn actigraphs has the potential for long-term measurement in t …
Resting-state EEG delta and alpha power predict response to cognitive behavioral therapy in depression: a Canadian biomarker integration network for depression study.
Schwartzmann B, Quilty LC, Dhami P, Uher R, Allen TA, Kloiber S, Lam RW, Frey BN, Milev R, Müller DJ, Soares CN, Foster JA, Rotzinger S, Kennedy SH, Farzan F. Schwartzmann B, et al. Among authors: frey bn. Sci Rep. 2023 May 24;13(1):8418. doi: 10.1038/s41598-023-35179-4. Sci Rep. 2023. PMID: 37225718 Free PMC article.
AI-based dimensional neuroimaging system for characterizing heterogeneity in brain structure and function in major depressive disorder: COORDINATE-MDD consortium design and rationale.
Fu CHY, Erus G, Fan Y, Antoniades M, Arnone D, Arnott SR, Chen T, Choi KS, Fatt CC, Frey BN, Frokjaer VG, Ganz M, Garcia J, Godlewska BR, Hassel S, Ho K, McIntosh AM, Qin K, Rotzinger S, Sacchet MD, Savitz J, Shou H, Singh A, Stolicyn A, Strigo I, Strother SC, Tosun D, Victor TA, Wei D, Wise T, Woodham RD, Zahn R, Anderson IM, Deakin JFW, Dunlop BW, Elliott R, Gong Q, Gotlib IH, Harmer CJ, Kennedy SH, Knudsen GM, Mayberg HS, Paulus MP, Qiu J, Trivedi MH, Whalley HC, Yan CG, Young AH, Davatzikos C. Fu CHY, et al. Among authors: frey bn. BMC Psychiatry. 2023 Jan 23;23(1):59. doi: 10.1186/s12888-022-04509-7. BMC Psychiatry. 2023. PMID: 36690972 Free PMC article.
Patient Selection and Clinical Indication for Chronic Total Occlusion Revascularization-A Workflow Focusing on Non-Invasive Cardiac Imaging.
Hamzaraj K, Kammerlander A, Gyöngyösi M, Frey B, Distelmaier K, Graf S. Hamzaraj K, et al. Among authors: frey b. Life (Basel). 2022 Dec 20;13(1):4. doi: 10.3390/life13010004. Life (Basel). 2022. PMID: 36675954 Free PMC article. Review.
Percutaneous coronary intervention of chronic total occlusion (CTO PCI) is a challenging procedure with high complication rates and, as not yet fully understood long-term clinical benefits. Ischemic symptom relief in patients with high ischemic burden is to date the only e …
Percutaneous coronary intervention of chronic total occlusion (CTO PCI) is a challenging procedure with high complication rates and, as not …
Gray matter volume drives the brain age gap in schizophrenia: a SHAP study.
Ballester PL, Suh JS, Ho NCW, Liang L, Hassel S, Strother SC, Arnott SR, Minuzzi L, Sassi RB, Lam RW, Milev R, Müller DJ, Taylor VH, Kennedy SH, Reilly JP, Palaniyappan L, Dunlop K, Frey BN. Ballester PL, et al. Among authors: frey bn. Schizophrenia (Heidelb). 2023 Jan 9;9(1):3. doi: 10.1038/s41537-022-00330-z. Schizophrenia (Heidelb). 2023. PMID: 36624107 Free PMC article.
These analyses identified total gray matter volume (group SHAP interaction term beta = 1.71 [0.53; 3.23]; p(corr) < 0.03) as the feature that influences the BAG observed in SCZ among the brain features that are most predictive of brain age. ...

These analyses identified total gray matter volume (group SHAP interaction term beta = 1.71 [0.53; 3.23]; p(corr) < 0.03) as the f

Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region.
Emmenegger M, De Cecco E, Lamparter D, Jacquat RPB, Riou J, Menges D, Ballouz T, Ebner D, Schneider MM, Morales IC, Doğançay B, Guo J, Wiedmer A, Domange J, Imeri M, Moos R, Zografou C, Batkitar L, Madrigal L, Schneider D, Trevisan C, Gonzalez-Guerra A, Carrella A, Dubach IL, Xu CK, Meisl G, Kosmoliaptsis V, Malinauskas T, Burgess-Brown N, Owens R, Hatch S, Mongkolsapaya J, Screaton GR, Schubert K, Huck JD, Liu F, Pojer F, Lau K, Hacker D, Probst-Müller E, Cervia C, Nilsson J, Boyman O, Saleh L, Spanaus K, von Eckardstein A, Schaer DJ, Ban N, Tsai CJ, Marino J, Schertler GFX, Ebert N, Thiel V, Gottschalk J, Frey BM, Reimann RR, Hornemann S, Ring AM, Knowles TPJ, Puhan MA, Althaus CL, Xenarios I, Stuart DI, Aguzzi A. Emmenegger M, et al. Among authors: frey bm. iScience. 2023 Feb 17;26(2):105928. doi: 10.1016/j.isci.2023.105928. Epub 2023 Jan 4. iScience. 2023. PMID: 36619367 Free PMC article.
A follow-up health survey indicated that about 10% of patients infected with wildtype SARS-CoV-2 sustained some symptoms at least twelve months post COVID-19. Crucially, we found no evidence of a difference in long-term complications between those whose infection was sympt …
A follow-up health survey indicated that about 10% of patients infected with wildtype SARS-CoV-2 sustained some symptoms at least twelve mon …
Long-term mercury contamination does not affect the microbial gene potential for C and N cycling in soils but enhances detoxification gene abundance.
Frey B, Rast BM, Qi W, Stierli B, Brunner I. Frey B, et al. Front Microbiol. 2022 Oct 5;13:1034138. doi: 10.3389/fmicb.2022.1034138. eCollection 2022. Front Microbiol. 2022. PMID: 36274742 Free PMC article.
Soil microorganisms are key transformers of mercury (Hg), a toxic and widespread pollutant. It remains uncertain, however, how long-term exposure to Hg affects crucial microbial functions, such as litter decomposition and nitrogen cycling. ...Overall, we conclude from this …
Soil microorganisms are key transformers of mercury (Hg), a toxic and widespread pollutant. It remains uncertain, however, how long-term
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