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Page 1
Coronary Angiography After Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation: One-Year Outcomes of a Randomized Clinical Trial.
Desch S, Freund A, Akin I, Behnes M, Preusch MR, Zelniker TA, Skurk C, Landmesser U, Graf T, Eitel I, Fuernau G, Haake H, Nordbeck P, Hammer F, Felix SB, Hassager C, Kjærgaard J, Fichtlscherer S, Ledwoch J, Lenk K, Joner M, Steiner S, Liebetrau C, Voigt I, Zeymer U, Brand M, Schmitz R, Horstkotte J, Jacobshagen C, Pöss J, Abdel-Wahab M, Lurz P, Jobs A, de Waha S, Olbrich D, Sandig F, König IR, Brett S, Vens M, Klinge K, Thiele H; TOMAHAWK Investigators. Desch S, et al. Among authors: freund a. JAMA Cardiol. 2023 Sep 1;8(9):827-834. doi: 10.1001/jamacardio.2023.2264. JAMA Cardiol. 2023. PMID: 37556123
IMPORTANCE: Myocardial infarction is a frequent cause of out-of-hospital cardiac arrest (OHCA). The long-term effect of early coronary angiography on patients with OHCA with possible coronary trigger but no ST-segment elevation remains unclear. ...
IMPORTANCE: Myocardial infarction is a frequent cause of out-of-hospital cardiac arrest (OHCA). The long-term effect of early coronar …
Impact of Clonal Hematopoiesis in Patients With Cardiogenic Shock Complicating Acute Myocardial Infarction.
Böhme M, Desch S, Rosolowski M, Scholz M, Krohn K, Büttner P, Cross M, Kirchberg J, Rommel KP, Pöss J, Freund A, Baber R, Isermann B, Ceglarek U, Metzeler KH, Platzbecker U, Thiele H. Böhme M, et al. Among authors: freund a. J Am Coll Cardiol. 2022 Oct 18;80(16):1545-1556. doi: 10.1016/j.jacc.2022.08.740. J Am Coll Cardiol. 2022. PMID: 36229091 Free article.
Compared to non-CHIP patients, CHIP carriers were older and had decreased renal function and increased levels of N-terminal pro-B-type natriuretic peptide and inflammatory biomarkers. CHIP carriers had worse short-term outcomes measured either as mortality or as the combin …
Compared to non-CHIP patients, CHIP carriers were older and had decreased renal function and increased levels of N-terminal pro-B-type natri …
Early coronary angiography in patients after out-of-hospital cardiac arrest without ST-segment elevation: Meta-analysis of randomized controlled trials.
Freund A, van Royen N, Kern KB, Jobs A, Thiele H, Lemkes JS, Desch S; TOMAHAWK, PEARL, and COACT investigators. Freund A, et al. Catheter Cardiovasc Interv. 2022 Sep;100(3):330-337. doi: 10.1002/ccd.30355. Epub 2022 Jul 28. Catheter Cardiovasc Interv. 2022. PMID: 35900214
METHODS: We searched MEDLINE and the Cochrane Central Register of Controlled Trials for RCTs comparing early with delayed or selective coronary angiography in OHCA patients of possible cardiac origin without ST-segment elevation. The primary endpoint was all-cause short-term …
METHODS: We searched MEDLINE and the Cochrane Central Register of Controlled Trials for RCTs comparing early with delayed or selective coron …
Comparison of risk prediction models in infarct-related cardiogenic shock.
Freund A, Pöss J, de Waha-Thiele S, Meyer-Saraei R, Fuernau G, Eitel I, Feistritzer HJ, Rubini M, Huber K, Windecker S, Montalescot G, Oldroyd K, Noc M, Zeymer U, Ouarrak T, Schneider S, Baran DA, Desch S, Thiele H. Freund A, et al. Eur Heart J Acute Cardiovasc Care. 2021 Oct 27;10(8):890-897. doi: 10.1093/ehjacc/zuab054. Eur Heart J Acute Cardiovasc Care. 2021. PMID: 34529043
The SCAI classification as a categorical predictive model displayed good prognostic assessment for the highest risk group (Stage E) but showed poor discrimination between Stages C and D with respect to short-term-mortality. CONCLUSION: Based on the present findings, the IA …
The SCAI classification as a categorical predictive model displayed good prognostic assessment for the highest risk group (Stage E) but show …
Catheter-directed therapy in pulmonary embolism.
Sulimov DS, Freund A, Thiele H. Sulimov DS, et al. Among authors: freund a. Herz. 2021 Oct;46(5):399-405. doi: 10.1007/s00059-021-05059-6. Epub 2021 Sep 1. Herz. 2021. PMID: 34468788 Review. English.
Acute pulmonary embolism (PE) is a life-threatening condition with high mortality rates and potential long-term sequelae. Systemic thrombolysis has been virtually the only therapeutic option available for patients with hemodynamic instability over decades. ...
Acute pulmonary embolism (PE) is a life-threatening condition with high mortality rates and potential long-term sequelae. Systemic th …
Management of cardiogenic shock.
Thiele H, de Waha-Thiele S, Freund A, Zeymer U, Desch S, Fitzgerald S. Thiele H, et al. Among authors: freund a. EuroIntervention. 2021 Aug 27;17(6):451-465. doi: 10.4244/EIJ-D-20-01296. EuroIntervention. 2021. PMID: 34413010 Free PMC article. Review.
Despite the rapidly evolving evidence base in modern cardiology, progress in the area of cardiogenic shock remains slow, with short-term mortality still reaching 40-50%, relatively unchanged in recent years. ...
Despite the rapidly evolving evidence base in modern cardiology, progress in the area of cardiogenic shock remains slow, with short-term …
Managing conflicting goals through prioritization? The role of age and relative goal importance.
Freund AM, Tomasik MJ. Freund AM, et al. PLoS One. 2021 Feb 19;16(2):e0247047. doi: 10.1371/journal.pone.0247047. eCollection 2021. PLoS One. 2021. PMID: 33606772 Free PMC article.
Thus, when encountering conflicting goals older adults prioritize more than younger adults, but prioritization might not be optimal for solving short-term goal conflict when both conflicting goals are equally important....
Thus, when encountering conflicting goals older adults prioritize more than younger adults, but prioritization might not be optimal for solv …
Impact of timing of intraaortic balloon counterpulsation on mortality in cardiogenic shock - a subanalysis of the IABP-SHOCK II trial.
Fuernau G, Ledwoch J, Desch S, Eitel I, Thelemann N, Jung C, de Waha-Thiele S, Pöss J, Feistritzer HJ, Freund A, Schneider S, Ouarrak T, Werdan K, Zeymer U, Thiele H. Fuernau G, et al. Among authors: freund a. Eur Heart J Acute Cardiovasc Care. 2020 Jun 10:2048872620930509. doi: 10.1177/2048872620930509. Online ahead of print. Eur Heart J Acute Cardiovasc Care. 2020. PMID: 32517482
There were no differences in baseline arterial lactate (p = 0.70), Simplified Acute Physiology Score-II-score (p = 0.60) and other relevant baseline characteristics. No differences were observed for short- and long-term mortality (pre vs. post 30-day mortality: 36% vs. 37% …
There were no differences in baseline arterial lactate (p = 0.70), Simplified Acute Physiology Score-II-score (p = 0.60) and other relevant …
[Cardiogenic Shock Complicating Myocardial Infarction].
Obradovic D, Freund A, Desch S, Thiele H. Obradovic D, et al. Among authors: freund a. Dtsch Med Wochenschr. 2020 May;145(9):624-632. doi: 10.1055/a-1106-3325. Epub 2020 Apr 29. Dtsch Med Wochenschr. 2020. PMID: 32349150 Review. German.
Although the use of active mechanical circulatory support appears to be a promising therapeutic concept to improve clinical outcome in patients with infarct-related cardiogenic shock, in the few previous randomized trials mechanical circulatory support failed to show beneficial e …
Although the use of active mechanical circulatory support appears to be a promising therapeutic concept to improve clinical outcome in patie …
Coronary collaterals in patients with ST-elevation myocardial infarction presenting late after symptom onset.
Freund A, Stiermaier T, de Waha-Thiele S, Eitel I, Schock S, Lurz P, Thiele H, Desch S. Freund A, et al. Clin Res Cardiol. 2020 Oct;109(10):1307-1315. doi: 10.1007/s00392-020-01625-w. Epub 2020 Mar 13. Clin Res Cardiol. 2020. PMID: 32170359 Clinical Trial.
Further, mortality at 4-years follow-up was lower (6% Rentrop grade 2 or 3 vs. 25% Rentrop grade 0 or 1, p = 0.02). Poor collateralization was an independent predictor of long-term mortality on multivariate Cox regression analyses in addition to cardiogenic shock and unsuc …
Further, mortality at 4-years follow-up was lower (6% Rentrop grade 2 or 3 vs. 25% Rentrop grade 0 or 1, p = 0.02). Poor collateralization w …
23 results