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Therapeutic beta-lactam dosages and broad-spectrum antibiotics are associated with reductions in microbial richness and diversity in persons with cystic fibrosis.
Hahn A, Burrell A, Chaney H, Sami I, Koumbourlis AC, Freishtat RJ, Crandall KA, Zemanick ET. Hahn A, et al. Among authors: freishtat rj. Sci Rep. 2023 Jan 21;13(1):1217. doi: 10.1038/s41598-023-27628-x. Sci Rep. 2023. PMID: 36681756 Free PMC article.
While higher microbial diversity is associated with higher lung function, the data on the impact of short-term antibiotics on changes in microbial diversity is conflicting. ...
While higher microbial diversity is associated with higher lung function, the data on the impact of short-term antibiotics on changes …
Parental obesity-induced changes in developmental programming.
Cechinel LR, Batabyal RA, Freishtat RJ, Zohn IE. Cechinel LR, et al. Among authors: freishtat rj. Front Cell Dev Biol. 2022 Oct 7;10:918080. doi: 10.3389/fcell.2022.918080. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36274855 Free PMC article. Review.
We describe essential phases of development impacted by parental obesity that contribute to long-term alterations in metabolism in the offspring. These encompass gamete formation, placentation, adipogenesis, pancreas development, and development of brain appetite control c …
We describe essential phases of development impacted by parental obesity that contribute to long-term alterations in metabolism in th …
Development of Persistent Respiratory Morbidity in Previously Healthy Children After Acute Respiratory Failure.
Keim G, Yehya N, Spear D, Hall MW, Loftis LL, Alten JA, McArthur J, Patwari PP, Freishtat RJ, Willson DF, Straumanis JP, Thomas NJ; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Keim G, et al. Among authors: freishtat rj. Crit Care Med. 2020 Aug;48(8):1120-1128. doi: 10.1097/CCM.0000000000004380. Crit Care Med. 2020. PMID: 32697481 Free PMC article.
OBJECTIVES: Acute respiratory failure is a common reason for admission to PICUs. Short- and long-term effects on pulmonary health in previously healthy children after acute respiratory failure requiring mechanical ventilation are unknown. ...
OBJECTIVES: Acute respiratory failure is a common reason for admission to PICUs. Short- and long-term effects on pulmonary health in …
Changes in microbiome diversity following beta-lactam antibiotic treatment are associated with therapeutic versus subtherapeutic antibiotic exposure in cystic fibrosis.
Hahn A, Fanous H, Jensen C, Chaney H, Sami I, Perez GF, Koumbourlis AC, Louie S, Bost JE, van den Anker JN, Freishtat RJ, Zemanick ET, Crandall KA. Hahn A, et al. Among authors: freishtat rj. Sci Rep. 2019 Feb 22;9(1):2534. doi: 10.1038/s41598-019-38984-y. Sci Rep. 2019. PMID: 30796252 Free PMC article.
In persons with cystic fibrosis (CF), decreased airway microbial diversity is associated with lower lung function. Conflicting data exist on the impact of short-term antibiotics for treatment of acute pulmonary exacerbations. ...
In persons with cystic fibrosis (CF), decreased airway microbial diversity is associated with lower lung function. Conflicting data exist on …
Natural progression of childhood asthma symptoms and strong influence of sex and puberty.
Fu L, Freishtat RJ, Gordish-Dressman H, Teach SJ, Resca L, Hoffman EP, Wang Z. Fu L, et al. Among authors: freishtat rj. Ann Am Thorac Soc. 2014 Jul;11(6):939-44. doi: 10.1513/AnnalsATS.201402-084OC. Ann Am Thorac Soc. 2014. PMID: 24896645 Free PMC article.
However, asthma symptom progression through childhood and adolescence has not been well studied, in part due to the challenges in obtaining consistent and robust long-term follow-up data on a large series of subjects with asthma. OBJECTIVES: To use the asthma diary symptom …
However, asthma symptom progression through childhood and adolescence has not been well studied, in part due to the challenges in obtaining …
VBP15, a glucocorticoid analogue, is effective at reducing allergic lung inflammation in mice.
Damsker JM, Dillingham BC, Rose MC, Balsley MA, Heier CR, Watson AM, Stemmy EJ, Jurjus RA, Huynh T, Tatem K, Uaesoontrachoon K, Berry DM, Benton AS, Freishtat RJ, Hoffman EP, McCall JM, Gordish-Dressman H, Constant SL, Reeves EK, Nagaraju K. Damsker JM, et al. Among authors: freishtat rj. PLoS One. 2013 May 7;8(5):e63871. doi: 10.1371/journal.pone.0063871. Print 2013. PLoS One. 2013. PMID: 23667681 Free PMC article.
Glucocorticoids such as prednisone have been standard treatment for many inflammatory diseases for the past 60 years. However, despite their effectiveness, long-term treatment is often limited by adverse side effects believed to be caused by glucocorticoid receptor-mediate …
Glucocorticoids such as prednisone have been standard treatment for many inflammatory diseases for the past 60 years. However, despite their …
Conserved steroid hormone homology converges on nuclear factor κB to modulate inflammation in asthma.
Payne AS, Freishtat RJ. Payne AS, et al. Among authors: freishtat rj. J Investig Med. 2012 Jan;60(1):13-7. doi: 10.2310/JIM.0b013e31823d7989. J Investig Med. 2012. PMID: 22183120 Free PMC article. Review.
Despite the complex pathogenesis of asthma, steroid hormones (eg, glucocorticoids) are ubiquitous in the short-term and long-term management of all types of asthma. Overall, steroid hormones are a class of widely relevant, biologically active compounds originating f …
Despite the complex pathogenesis of asthma, steroid hormones (eg, glucocorticoids) are ubiquitous in the short-term and long-term …