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Protease addiction and synthetic lethality in cancer.
Freije JM, Fraile JM, López-Otín C. Freije JM, et al. Front Oncol. 2011 Sep 5;1:25. doi: 10.3389/fonc.2011.00025. eCollection 2011. Front Oncol. 2011. PMID: 22655236 Free PMC article.
The "oncogene addiction" concept refers to the dependence of cancer cells on the function of the oncogenes responsible for their transformed phenotype, while the term "non-oncogene addiction" has been introduced to define the exacerbated necessity of the normal function of …
The "oncogene addiction" concept refers to the dependence of cancer cells on the function of the oncogenes responsible for their transformed …