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Adapted problem adaptation therapy for depression in mild to moderate Alzheimer's disease dementia: A randomized controlled trial.
Howard R, Cort E, Rawlinson C, Wiegand M, Downey A, Lawrence V, Banerjee S, Bentham P, Fox C, Harwood R, Hunter R, Livingston G, Moniz-Cook E, Panca M, Raczek M, Ivenso C, Russell G, Thomas A, Wilkinson P, Freemantle N, Gould R. Howard R, et al. Among authors: freemantle n. Alzheimers Dement. 2024 Apr;20(4):2990-2999. doi: 10.1002/alz.13766. Epub 2024 Mar 13. Alzheimers Dement. 2024. PMID: 38477423 Free PMC article. Clinical Trial.
Future studies should examine the effect of more intensive and longer-term therapy....
Future studies should examine the effect of more intensive and longer-term therapy....
Letter to the Editor Regarding 'Matching-Adjusted Indirect Comparison of the Long-Term Efficacy Maintenance and Adverse Event Rates of Lebrikizumab Versus Dupilumab in Moderate-to-Severe Atopic Dermatitis'.
Bastian M, Freemantle N, Rossi AB, Shumel B, Le Bagousse GB, Wang Z, Xu Y, Guyot P. Bastian M, et al. Among authors: freemantle n. Dermatol Ther (Heidelb). 2024 Mar;14(3):819-821. doi: 10.1007/s13555-024-01106-2. Epub 2024 Feb 16. Dermatol Ther (Heidelb). 2024. PMID: 38366176 Free PMC article. No abstract available.
Prevention of venous thromboembolism in acute spontaneous intracerebral haemorrhage: A survey of opinion.
Mendel R, Abdelhameed N, Salman RA, Cohen H, Dowlatshahi D, Freemantle N, Paciaroni M, Parry-Jones A, Price C, Sprigg N, Werring DJ. Mendel R, et al. Among authors: freemantle n. J Neurol Sci. 2023 Nov 15;454:120855. doi: 10.1016/j.jns.2023.120855. Epub 2023 Oct 25. J Neurol Sci. 2023. PMID: 38236754 Free article.
INTRODUCTION: People immobilized following acute spontaneous intracerebral haemorrhage (ICH) are at risk of venous thromboembolism (VTE) but the role of short-term prophylactic anticoagulation remains uncertain. We surveyed UK clinical practice and opinion regarding preven …
INTRODUCTION: People immobilized following acute spontaneous intracerebral haemorrhage (ICH) are at risk of venous thromboembolism (VTE) but …
Long-term health care resource and cost savings with allergy immunotherapy: REACT study results.
Fritzsching B, Porsbjerg C, Contoli M, Buchs S, Larsen JR, Freemantle N. Fritzsching B, et al. Among authors: freemantle n. J Allergy Clin Immunol Glob. 2023 Nov 23;3(1):100197. doi: 10.1016/j.jacig.2023.100197. eCollection 2024 Feb. J Allergy Clin Immunol Glob. 2023. PMID: 38226187 Free PMC article.
OBJECTIVE: Our aim was to assess the association of AIT (SCIT and SLIT tablets) with long-term health care resource use (HRU) and costs in subjects with allergic rhinitis. ...CONCLUSION: Initial higher HRU and costs of AIT during the expected treatment period are offset in …
OBJECTIVE: Our aim was to assess the association of AIT (SCIT and SLIT tablets) with long-term health care resource use (HRU) and cos …
Antipsychotic dose reduction and discontinuation versus maintenance treatment in people with schizophrenia and other recurrent psychotic disorders in England (the RADAR trial): an open, parallel-group, randomised controlled trial.
Moncrieff J, Crellin N, Stansfeld J, Cooper R, Marston L, Freemantle N, Lewis G, Hunter R, Johnson S, Barnes T, Morant N, Pinfold V, Smith R, Kent L, Darton K, Long M, Horowitz M, Horne R, Vickerstaff V, Jha M, Priebe S. Moncrieff J, et al. Among authors: freemantle n. Lancet Psychiatry. 2023 Nov;10(11):848-859. doi: 10.1016/S2215-0366(23)00258-4. Epub 2023 Sep 28. Lancet Psychiatry. 2023. PMID: 37778356 Free article. Clinical Trial.
Our hypothesis was that antipsychotic reduction would improve social functioning with a short-term increase in relapse. METHODS: RADAR was an open, parallel-group, randomised trial done in 19 National Health Service Trusts in England. ...INTERPRETATION: At 2-year follow-up …
Our hypothesis was that antipsychotic reduction would improve social functioning with a short-term increase in relapse. METHODS: RADA …
Real-world, long-term effectiveness of allergy immunotherapy in allergic rhinitis: Subgroup analyses of the REACT study.
Contoli M, Porsbjerg C, Buchs S, Larsen JR, Freemantle N, Fritzsching B. Contoli M, et al. Among authors: freemantle n. J Allergy Clin Immunol. 2023 Aug;152(2):445-452.e4. doi: 10.1016/j.jaci.2023.02.024. Epub 2023 Mar 3. J Allergy Clin Immunol. 2023. PMID: 36871918 Free article.
BACKGROUND: Randomized controlled trials have demonstrated the efficacy of allergy immunotherapy (AIT) in allergic rhinitis (AR) and the disease-modifying effects of the SQ grass sublingual immunotherapy (SLIT) tablet. OBJECTIVE: We sought to assess real-world, long-term e …
BACKGROUND: Randomized controlled trials have demonstrated the efficacy of allergy immunotherapy (AIT) in allergic rhinitis (AR) and the dis …
Five-year illness trajectories across racial groups in the UK following a first episode psychosis.
Griffiths SL, Bogatsu T, Longhi M, Butler E, Alexander B, Bandawar M, Everard L, Jones PB, Fowler D, Hodgekins J, Amos T, Freemantle N, McCrone P, Singh SP, Birchwood M, Upthegrove R. Griffiths SL, et al. Among authors: freemantle n. Soc Psychiatry Psychiatr Epidemiol. 2023 Apr;58(4):569-579. doi: 10.1007/s00127-023-02428-w. Epub 2023 Jan 30. Soc Psychiatry Psychiatr Epidemiol. 2023. PMID: 36717434 Free PMC article.
Finally, there was a greater likelihood for Asian (OR = 3.04; 95% CI [2.050, 4.498]) and Black individuals (OR = 2.47; 95% CI [1.354, 4.520]) to remain in secondary care by follow-up. CONCLUSION: Findings suggest variations in long-term clinical and social outcomes followi …
Finally, there was a greater likelihood for Asian (OR = 3.04; 95% CI [2.050, 4.498]) and Black individuals (OR = 2.47; 95% CI [1.354, 4.520] …
Favipiravir, lopinavir-ritonavir, or combination therapy (FLARE): A randomised, double-blind, 2 × 2 factorial placebo-controlled trial of early antiviral therapy in COVID-19.
Lowe DM, Brown LK, Chowdhury K, Davey S, Yee P, Ikeji F, Ndoutoumou A, Shah D, Lennon A, Rai A, Agyeman AA, Checkley A, Longley N, Dehbi HM, Freemantle N, Breuer J, Standing JF; FLARE Investigators. Lowe DM, et al. Among authors: freemantle n. PLoS Med. 2022 Oct 19;19(10):e1004120. doi: 10.1371/journal.pmed.1004120. eCollection 2022 Oct. PLoS Med. 2022. PMID: 36260627 Free PMC article. Clinical Trial.
There was no significant interaction between favipiravir and lopinavir-ritonavir (interaction coefficient term: 0.59 log10, 95% CI -0.32 to 1.50, p = 0.20). More participants had undetectable virus at Day 5 in the favipiravir+placebo arm compared to placebo only (46.3% ver …
There was no significant interaction between favipiravir and lopinavir-ritonavir (interaction coefficient term: 0.59 log10, 95% CI -0 …
Evaluating the Role of Antibiotics in Patients Admitted to Hospital With Decompensated Cirrhosis: Lessons From the ATTIRE Trial.
Kutmutia R, Tittanegro T, China L, Forrest E, Kallis Y, Ryder SD, Wright G, Freemantle N, O'Brien A. Kutmutia R, et al. Among authors: freemantle n. Am J Gastroenterol. 2023 Jan 1;118(1):105-113. doi: 10.14309/ajg.0000000000001937. Epub 2022 Aug 12. Am J Gastroenterol. 2023. PMID: 35970815 Free PMC article.
In noninfected patients at enrollment treated with/without rifaximin, there were no differences in HAI ( P = 0.16) or mortality, confirmed with propensity matching. Patients given long-term antibiotic prophylaxis at discharge had no differences in 6-month mortality compare …
In noninfected patients at enrollment treated with/without rifaximin, there were no differences in HAI ( P = 0.16) or mortality, confirmed w …
Target Trial Emulation for Transparent and Robust Estimation of Treatment Effects for Health Technology Assessment Using Real-World Data: Opportunities and Challenges.
Gomes M, Latimer N, Soares M, Dias S, Baio G, Freemantle N, Dawoud D, Wailoo A, Grieve R. Gomes M, et al. Among authors: freemantle n. Pharmacoeconomics. 2022 Jun;40(6):577-586. doi: 10.1007/s40273-022-01141-x. Epub 2022 Mar 25. Pharmacoeconomics. 2022. PMID: 35332434 Free article.
In many instances, evidence from RCTs falls short of the needs of health technology assessment (HTA). For example, RCTs may not be able to capture longer-term treatment effects, or include all relevant comparators and outcomes required for HTA purposes. ...
In many instances, evidence from RCTs falls short of the needs of health technology assessment (HTA). For example, RCTs may not be able to c …
73 results