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Higher Renal Net Acid Excretion, but Not Higher Phosphate Excretion, during Childhood and Adolescence Associates with the Circulating Renal Tubular Injury Marker Interleukin-18 in Adulthood.
Derakhshandeh-Rishehri SM, Franco LP, Hua Y, Herder C, Kalhoff H, Frassetto LA, Wudy SA, Remer T. Derakhshandeh-Rishehri SM, et al. Among authors: frassetto la. Int J Mol Sci. 2024 Jan 24;25(3):1408. doi: 10.3390/ijms25031408. Int J Mol Sci. 2024. PMID: 38338685 Free PMC article.
After adjusting for growth- and adulthood-related covariates and pro-inflammatory biomarkers to rule out confounding by non-renal inflammatory processes, regression models revealed a significant positive relationship of long-term NAE (p = 0.01), but not of long-term …
After adjusting for growth- and adulthood-related covariates and pro-inflammatory biomarkers to rule out confounding by non-renal inflammato …
Dietary Contributions to Metabolic Acidosis.
Frassetto L, Remer T, Banerjee T. Frassetto L, et al. Adv Chronic Kidney Dis. 2022 Jul;29(4):373-380. doi: 10.1053/j.ackd.2022.03.008. Adv Chronic Kidney Dis. 2022. PMID: 36175075 Review.
Alkaline diets based on fruits and vegetables may have a positive effect on long-term preservation of renal function while maintaining nutritional status. ...
Alkaline diets based on fruits and vegetables may have a positive effect on long-term preservation of renal function while maintainin …
A Comparative Analysis of the Safety, Efficacy, and Cost of Islet Versus Pancreas Transplantation in Nonuremic Patients With Type 1 Diabetes.
Moassesfar S, Masharani U, Frassetto LA, Szot GL, Tavakol M, Stock PG, Posselt AM. Moassesfar S, et al. Among authors: frassetto la. Am J Transplant. 2016 Feb;16(2):518-26. doi: 10.1111/ajt.13536. Epub 2015 Nov 23. Am J Transplant. 2016. PMID: 26595767 Free PMC article.
We conclude that with advances in islet isolation and posttransplant management, ITA can produce outcomes similar to PTA and represents a clinically viable option to achieve long-term insulin independence in selected patients with T1D....
We conclude that with advances in islet isolation and posttransplant management, ITA can produce outcomes similar to PTA and represents a cl …
Metabolic and physiologic effects from consuming a hunter-gatherer (Paleolithic)-type diet in type 2 diabetes.
Masharani U, Sherchan P, Schloetter M, Stratford S, Xiao A, Sebastian A, Nolte Kennedy M, Frassetto L. Masharani U, et al. Among authors: frassetto l. Eur J Clin Nutr. 2015 Aug;69(8):944-8. doi: 10.1038/ejcn.2015.39. Epub 2015 Apr 1. Eur J Clin Nutr. 2015. PMID: 25828624 Clinical Trial.
Also, on the Paleo diet, the most insulin-resistant subjects had a significant improvement in insulin sensitivity (r = 0.40, P = 0.02), but no such effect was seen in the most insulin-resistant subjects on the ADA diet (r = 0.39, P = 0.3). CONCLUSIONS: Even short-term cons …
Also, on the Paleo diet, the most insulin-resistant subjects had a significant improvement in insulin sensitivity (r = 0.40, P = 0.02), but …
Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base.
Feinman RD, Pogozelski WK, Astrup A, Bernstein RK, Fine EJ, Westman EC, Accurso A, Frassetto L, Gower BA, McFarlane SI, Nielsen JV, Krarup T, Saslow L, Roth KS, Vernon MC, Volek JS, Wilshire GB, Dahlqvist A, Sundberg R, Childers A, Morrison K, Manninen AH, Dashti HM, Wood RJ, Wortman J, Worm N. Feinman RD, et al. Among authors: frassetto l. Nutrition. 2015 Jan;31(1):1-13. doi: 10.1016/j.nut.2014.06.011. Epub 2014 Jul 16. Nutrition. 2015. PMID: 25287761 Free article. Review.
The benefits of carbohydrate restriction in diabetes are immediate and well documented. Concerns about the efficacy and safety are long term and conjectural rather than data driven. Dietary carbohydrate restriction reliably reduces high blood glucose, does not require weig …
The benefits of carbohydrate restriction in diabetes are immediate and well documented. Concerns about the efficacy and safety are long t …
A healthy diet with and without cereal grains and dairy products in patients with type 2 diabetes: study protocol for a random-order cross-over pilot study--Alimentation and Diabetes in Lanzarote--ADILAN.
Fontes-Villalba M, Jönsson T, Granfeldt Y, Frassetto LA, Sundquist J, Sundquist K, Carrera-Bastos P, Fika-Hernándo M, Picazo Ó, Lindeberg S. Fontes-Villalba M, et al. Among authors: frassetto la. Trials. 2014 Jan 2;15:2. doi: 10.1186/1745-6215-15-2. Trials. 2014. PMID: 24383431 Free PMC article. Clinical Trial.
BACKGROUND: Research on the role of nutrition in type 2 diabetes has largely focused on macro/micronutrient composition and dietary fiber intake, while fewer studies have tested the effects of differing food choice. Some observational studies and short-term intervention st …
BACKGROUND: Research on the role of nutrition in type 2 diabetes has largely focused on macro/micronutrient composition and dietary fiber in …
No evidence that the skeletal non-response to potassium alkali supplements in healthy postmenopausal women depends on blood pressure or sodium chloride intake.
Frassetto LA, Hardcastle AC, Sebastian A, Aucott L, Fraser WD, Reid DM, Macdonald HM. Frassetto LA, et al. Eur J Clin Nutr. 2012 Dec;66(12):1315-22. doi: 10.1038/ejcn.2012.151. Epub 2012 Oct 24. Eur J Clin Nutr. 2012. PMID: 23093337 Clinical Trial.
SUBJECTS/METHODS: We retrospectively analysed data from two data sets (California and NE Scotland) of postmenopausal women (n=266) enrolled in long-term randomized, placebo-controlled studies of the effects of administration of low- or high-dose dietary K alkali supplement …
SUBJECTS/METHODS: We retrospectively analysed data from two data sets (California and NE Scotland) of postmenopausal women (n=266) enrolled …
Long term higher urinary calcium excretion within the normal physiologic range predicts impaired bone status of the proximal radius in healthy children with higher potential renal acid load.
Shi L, Libuda L, Schönau E, Frassetto L, Remer T. Shi L, et al. Among authors: frassetto l. Bone. 2012 May;50(5):1026-31. doi: 10.1016/j.bone.2012.01.026. Epub 2012 Feb 9. Bone. 2012. PMID: 22342797
Stratified analyses based on the median split of uPRAL showed that calcium excretion was negatively associated with vBMD (P=0.007), cortical BMC (P=0.001), and cortical CSA (P=0.004) in those children with higher uPRALs, but not in those with low uPRALs (P>0.3). In conclusion, …
Stratified analyses based on the median split of uPRAL showed that calcium excretion was negatively associated with vBMD (P=0.007), cortical …
Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade.
Posselt AM, Szot GL, Frassetto LA, Masharani U, Tavakol M, Amin R, McElroy J, Ramos MD, Kerlan RK, Fong L, Vincenti F, Bluestone JA, Stock PG. Posselt AM, et al. Among authors: frassetto la. Transplantation. 2010 Dec 27;90(12):1595-601. doi: 10.1097/TP.0b013e3181fe1377. Transplantation. 2010. PMID: 20978464 Free PMC article.
BACKGROUND: The applicability of islet transplantation as treatment for type 1 diabetes is limited by long-term graft dysfunction, immunosuppressive drug toxicity, need for multiple donors, and increased risk of allosensitization. We describe two immunosuppressive regimens …
BACKGROUND: The applicability of islet transplantation as treatment for type 1 diabetes is limited by long-term graft dysfunction, im …
Islet transplantation in type 1 diabetics using an immunosuppressive protocol based on the anti-LFA-1 antibody efalizumab.
Posselt AM, Bellin MD, Tavakol M, Szot GL, Frassetto LA, Masharani U, Kerlan RK, Fong L, Vincenti FG, Hering BJ, Bluestone JA, Stock PG. Posselt AM, et al. Among authors: frassetto la. Am J Transplant. 2010 Aug;10(8):1870-80. doi: 10.1111/j.1600-6143.2010.03073.x. Am J Transplant. 2010. PMID: 20659093 Free PMC article.
We describe a novel immunosuppressive regimen using the antileukocyte functional antigen-1 antibody efalizumab which permits long-term islet allograft survival while reducing the need for corticosteroids and calcineurin inhibitors (CNI). ...Such an approach may minimize re …
We describe a novel immunosuppressive regimen using the antileukocyte functional antigen-1 antibody efalizumab which permits long-term …
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