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Multidisciplinary ecosystem to study lifecourse determinants and prevention of early-onset burdensome multimorbidity (MELD-B) - protocol for a research collaboration.
Fraser SD, Stannard S, Holland E, Boniface M, Hoyle RB, Wilkinson R, Akbari A, Ashworth M, Berrington A, Chiovoloni R, Enright J, Francis NA, Giles G, Gulliford M, Macdonald S, Mair FS, Owen RK, Paranjothy S, Parsons H, Sanchez-Garcia RJ, Shiranirad M, Zlatev Z, Alwan N. Fraser SD, et al. Among authors: francis na. J Multimorb Comorb. 2023 Sep 25;13:26335565231204544. doi: 10.1177/26335565231204544. eCollection 2023 Jan-Dec. J Multimorb Comorb. 2023. PMID: 37766757 Free PMC article.
BACKGROUND: Most people living with multiple long-term condition multimorbidity (MLTC-M) are under 65 (defined as 'early onset'). Earlier and greater accrual of long-term conditions (LTCs) may be influenced by the timing and nature of exposure to key risk factors, w …
BACKGROUND: Most people living with multiple long-term condition multimorbidity (MLTC-M) are under 65 (defined as 'early onset'). Ear …
Gut microbiology of UK care home residents: a cross-sectional analysis from a randomised controlled trial.
Gillespie D, Wootton M, Ray R, Calder PC, Mandy Lau TM, Owen-Jones E, Lowe R, Davies L, Richards J, Hood K, Castro-Herrera V, Davies J, Francis NA, Hobbs FDR, Lown M, Moore M, Shepherd V, Butler CC. Gillespie D, et al. Among authors: francis na. Clin Microbiol Infect. 2023 Aug 17:S1198-743X(23)00362-2. doi: 10.1016/j.cmi.2023.08.001. Online ahead of print. Clin Microbiol Infect. 2023. PMID: 37595801 Free article.
Is there an association between long-term antibiotics for acne and subsequent infection sequelae and antimicrobial resistance? A systematic review protocol.
Bhate K, Lin LY, Barbieri J, Leyrat C, Hopkins S, Stabler R, Shallcross L, Smeeth L, Francis NA, Mathur R, Langan SM, Sinnott SJ. Bhate K, et al. Among authors: francis na. BMJ Open. 2020 Jul 2;10(7):e033662. doi: 10.1136/bmjopen-2019-033662. BMJ Open. 2020. PMID: 32616485 Free PMC article.
METHODS AND ANALYSIS: A systematic review will be conducted to address the question: What is the existing evidence that long-term oral antibiotics used to treat acne in those over 8 years of age contribute towards antibiotic treatment failure or other outcomes suggestive o …
METHODS AND ANALYSIS: A systematic review will be conducted to address the question: What is the existing evidence that long-term ora …
C-reactive protein point-of-care testing for safely reducing antibiotics for acute exacerbations of chronic obstructive pulmonary disease: the PACE RCT.
Francis NA, Gillespie D, White P, Bates J, Lowe R, Sewell B, Phillips R, Stanton H, Kirby N, Wootton M, Thomas-Jones E, Hood K, Llor C, Cals J, Melbye H, Naik G, Gal M, Fitzsimmons D, Alam MF, Riga E, Cochrane A, Butler CC. Francis NA, et al. Health Technol Assess. 2020 Mar;24(15):1-108. doi: 10.3310/hta24150. Health Technol Assess. 2020. PMID: 32202490 Free PMC article. Clinical Trial.
FUTURE WORK: Implementation studies that also build on our qualitative findings could help determine the effect of this intervention over the longer term. TRIAL REGISTRATION: Current Controlled Trials ISRCTN24346473. ...
FUTURE WORK: Implementation studies that also build on our qualitative findings could help determine the effect of this intervention over th …
Long-term outcomes of urinary tract infection (UTI) in Childhood (LUCI): protocol for an electronic record-linked cohort study.
Lugg-Widger FV, Angel L, Cannings-John R, Jones H, Lau M, Butler C, Francis NA, Hay AD, Heginbothom M, Hood K, Paranjothy S, Vandervoort J, Hughes K. Lugg-Widger FV, et al. Among authors: francis na. BMJ Open. 2019 Apr 20;9(4):e024210. doi: 10.1136/bmjopen-2018-024210. BMJ Open. 2019. PMID: 31005909 Free PMC article.
INTRODUCTION: Current guidelines advise the prompt diagnosis and treatment of urinary tract infection (UTI) in children to improve both short and longer term outcomes. However, the risk of long-term complications following childhood UTI is unclear.UTI is relatively …
INTRODUCTION: Current guidelines advise the prompt diagnosis and treatment of urinary tract infection (UTI) in children to improve both shor …
Oral steroids for hearing loss associated with otitis media with effusion in children aged 2-8 years: the OSTRICH RCT.
Francis NA, Waldron CA, Cannings-John R, Thomas-Jones E, Winfield T, Shepherd V, Harris D, Hood K, Fitzsimmons D, Roberts A, Powell CV, Gal M, Jones S, Butler CC. Francis NA, et al. Health Technol Assess. 2018 Nov;22(61):1-114. doi: 10.3310/hta22610. Health Technol Assess. 2018. PMID: 30407151 Free PMC article. Clinical Trial.
A safe, inexpensive, effective medical treatment would enhance treatment options. Small, poorly conducted trials have found a short-term benefit from oral steroids. OBJECTIVE: To determine the clinical effectiveness and cost-effectiveness of a 7-day course of oral steroids …
A safe, inexpensive, effective medical treatment would enhance treatment options. Small, poorly conducted trials have found a short-term …
Oral steroids for resolution of otitis media with effusion in children (OSTRICH): a double-blinded, placebo-controlled randomised trial.
Francis NA, Cannings-John R, Waldron CA, Thomas-Jones E, Winfield T, Shepherd V, Harris D, Hood K, Fitzsimmons D, Roberts A, Powell C, Gal M, Butler CC. Francis NA, et al. Lancet. 2018 Aug 18;392(10147):557-568. doi: 10.1016/S0140-6736(18)31490-9. Epub 2018 Aug 16. Lancet. 2018. PMID: 30152390 Free PMC article. Clinical Trial.
A safe, cheap, and effective medical treatment would enhance treatment options. Underpowered, poor-quality trials have found short-term benefit from oral steroids. We aimed to investigate whether a short course of oral steroids would achieve acceptable hearing in children …
A safe, cheap, and effective medical treatment would enhance treatment options. Underpowered, poor-quality trials have found short-term …
A randomised placebo-controlled trial of oral and topical antibiotics for children with clinically infected eczema in the community: the ChildRen with Eczema, Antibiotic Management (CREAM) study.
Francis NA, Ridd MJ, Thomas-Jones E, Shepherd V, Butler CC, Hood K, Huang C, Addison K, Longo M, Marwick C, Wootton M, Howe R, Roberts A, Haq MI, Madhok V, Sullivan F; CREAM team. Francis NA, et al. Health Technol Assess. 2016 Mar;20(19):i-xxiv, 1-84. doi: 10.3310/hta20190. Health Technol Assess. 2016. PMID: 26938214 Free PMC article. Clinical Trial.
Analyses of impact on the family, quality of life, daily symptom scores, and longer-term outcomes were all consistent with the finding of no or limited difference and a trend towards worse outcomes in the intervention groups. ...
Analyses of impact on the family, quality of life, daily symptom scores, and longer-term outcomes were all consistent with the findin …
Bath additives for the treatment of childhood eczema (BATHE): protocol for multicentre parallel group randomised trial.
Santer M, Rumsby K, Ridd MJ, Francis NA, Stuart B, Chorozoglou M, Wood W, Roberts A, Thomas KS, Williams HC, Little P. Santer M, et al. Among authors: francis na. BMJ Open. 2015 Nov 1;5(10):e009575. doi: 10.1136/bmjopen-2015-009575. BMJ Open. 2015. PMID: 26525422 Free PMC article. Clinical Trial.
INTERVENTIONS: Children will be randomised to either bath emollients plus standard eczema care or standard eczema care only. OUTCOME MEASURES: Primary outcome is long-term eczema severity, measured by the Patient-Oriented Eczema Measure (POEM) repeated weekly for 16 weeks. …
INTERVENTIONS: Children will be randomised to either bath emollients plus standard eczema care or standard eczema care only. OUTCOME MEASURE …
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