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Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment.
Howard JP, Wood FA, Finegold JA, Nowbar AN, Thompson DM, Arnold AD, Rajkumar CA, Connolly S, Cegla J, Stride C, Sever P, Norton C, Thom SAM, Shun-Shin MJ, Francis DP. Howard JP, et al. Among authors: francis dp. J Am Coll Cardiol. 2021 Sep 21;78(12):1210-1222. doi: 10.1016/j.jacc.2021.07.022. J Am Coll Cardiol. 2021. PMID: 34531021 Free PMC article. Clinical Trial.
Mechanical thrombectomy with retrievable stents and aspiration catheters for acute ischaemic stroke: a meta-analysis of randomised controlled trials.
Rajkumar CA, Ganesananthan S, Ahmad Y, Seligman H, Thornton GD, Foley M, Nowbar AN, Howard JP, Francis DP, Keeble TR, Grunwald IQ, Al-Lamee RK, Malik I, Shun-Shin MJ. Rajkumar CA, et al. Among authors: francis dp. EuroIntervention. 2022 Apr 1;17(17):e1425-e1434. doi: 10.4244/EIJ-D-21-00343. EuroIntervention. 2022. PMID: 34503942 Free PMC article.
AIMS: The aim of this analysis was to test the effect of mechanical thrombectomy on mortality and long-term neurological outcome in patients presenting with acute large-vessel anterior circulation ischaemic stroke. ...
AIMS: The aim of this analysis was to test the effect of mechanical thrombectomy on mortality and long-term neurological outcome in p …
Randomized Blinded Placebo-Controlled Trials of Renal Sympathetic Denervation for Hypertension: A Meta-Analysis.
Ahmad Y, Kane C, Arnold AD, Cook CM, Keene D, Shun-Shin M, Cole G, Al-Lamee R, Francis DP, Howard JP. Ahmad Y, et al. Among authors: francis dp. Cardiovasc Revasc Med. 2022 Jan;34:112-118. doi: 10.1016/j.carrev.2021.01.031. Epub 2021 Jan 30. Cardiovasc Revasc Med. 2022. PMID: 33551282 Free PMC article.
CONCLUSIONS: The totality of blinded, randomized placebo-controlled data shows that renal denervation is safe and provides genuine reduction in blood pressure for at least 6 months post-procedure. If this effect continues in the long term, renal denervation might provide a …
CONCLUSIONS: The totality of blinded, randomized placebo-controlled data shows that renal denervation is safe and provides genuine reduction …
Achieving Optimal Medical Therapy: Insights From the ORBITA Trial.
Foley M, Rajkumar CA, Shun-Shin M, Ganesananthan S, Seligman H, Howard J, Nowbar AN, Keeble TR, Davies JR, Tang KH, Gerber R, O'Kane P, Sharp ASP, Petraco R, Malik IS, Nijjer S, Sen S, Francis DP, Al-Lamee R. Foley M, et al. Among authors: francis dp. J Am Heart Assoc. 2021 Feb 2;10(3):e017381. doi: 10.1161/JAHA.120.017381. Epub 2021 Jan 26. J Am Heart Assoc. 2021. PMID: 33496201 Free PMC article. Clinical Trial.
Truly optimal medical therapy can be achieved in clinical trials, and translating this into longer-term clinical practice should be a focus of future study. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT02062593....
Truly optimal medical therapy can be achieved in clinical trials, and translating this into longer-term clinical practice should be a …
Within-patient comparison of His-bundle pacing, right ventricular pacing, and right ventricular pacing avoidance algorithms in patients with PR prolongation: Acute hemodynamic study.
Keene D, Shun-Shin MJ, Arnold AD, March K, Qureshi N, Ng FS, Tanner M, Linton N, Lim PB, Lefroy D, Kanagaratnam P, Peters NS, Francis DP, Whinnett ZI. Keene D, et al. Among authors: francis dp. J Cardiovasc Electrophysiol. 2020 Nov;31(11):2964-2974. doi: 10.1111/jce.14763. Epub 2020 Oct 5. J Cardiovasc Electrophysiol. 2020. PMID: 32976636
Clinical trials may be justified to assess whether these acute improvements translate into longer term clinical benefits in patients with bradycardia indications for pacing....
Clinical trials may be justified to assess whether these acute improvements translate into longer term clinical benefits in patients …
Invasive versus non-invasive management of older patients with non-ST elevation myocardial infarction (SENIOR-NSTEMI): a cohort study based on routine clinical data.
Kaura A, Sterne JAC, Trickey A, Abbott S, Mulla A, Glampson B, Panoulas V, Davies J, Woods K, Omigie J, Shah AD, Channon KM, Weber JN, Thursz MR, Elliott P, Hemingway H, Williams B, Asselbergs FW, O'Sullivan M, Lord GM, Melikian N, Johnson T, Francis DP, Shah AM, Perera D, Kharbanda R, Patel RS, Mayet J. Kaura A, et al. Among authors: francis dp. Lancet. 2020 Aug 29;396(10251):623-634. doi: 10.1016/S0140-6736(20)30930-2. Lancet. 2020. PMID: 32861307 Free PMC article.
BACKGROUND: Previous trials suggest lower long-term risk of mortality after invasive rather than non-invasive management of patients with non-ST elevation myocardial infarction (NSTEMI), but the trials excluded very elderly patients. ...
BACKGROUND: Previous trials suggest lower long-term risk of mortality after invasive rather than non-invasive management of patients …
Safety of Revascularization Deferral of Left Main Stenosis Based on Instantaneous Wave-Free Ratio Evaluation.
Warisawa T, Cook CM, Rajkumar C, Howard JP, Seligman H, Ahmad Y, El Hajj S, Doi S, Nakajima A, Nakayama M, Goto S, Vera-Urquiza R, Sato T, Kikuta Y, Kawase Y, Nishina H, Petraco R, Al-Lamee R, Nijjer S, Sen S, Nakamura S, Lerman A, Matsuo H, Francis DP, Akashi YJ, Escaned J, Davies JE. Warisawa T, et al. Among authors: francis dp. JACC Cardiovasc Interv. 2020 Jul 27;13(14):1655-1664. doi: 10.1016/j.jcin.2020.02.035. Epub 2020 May 13. JACC Cardiovasc Interv. 2020. PMID: 32417088 Free article.
OBJECTIVES: The aim of this study was to assess the long-term clinical outcomes of patients with left main coronary artery (LM) stenosis in whom treatment strategy was based on the instantaneous wave-free ratio (iFR). ...CONCLUSIONS: Deferral of revascularization of LM ste …
OBJECTIVES: The aim of this study was to assess the long-term clinical outcomes of patients with left main coronary artery (LM) steno …
Mortality after drug-eluting stents vs. coronary artery bypass grafting for left main coronary artery disease: a meta-analysis of randomized controlled trials.
Ahmad Y, Howard JP, Arnold AD, Cook CM, Prasad M, Ali ZA, Parikh MA, Kosmidou I, Francis DP, Moses JW, Leon MB, Kirtane AJ, Stone GW, Karmpaliotis D. Ahmad Y, et al. Among authors: francis dp. Eur Heart J. 2020 Sep 7;41(34):3228-3235. doi: 10.1093/eurheartj/ehaa135. Eur Heart J. 2020. PMID: 32118272 Free PMC article.
CONCLUSION: The totality of randomized clinical trial evidence demonstrated similar long-term mortality after PCI with DES compared with CABG in patients with LMCAD. ...
CONCLUSION: The totality of randomized clinical trial evidence demonstrated similar long-term mortality after PCI with DES compared w …
Optimum lesion set and predictors of outcome in persistent atrial fibrillation ablation: a meta-regression analysis.
Sau A, Al-Aidarous S, Howard J, Shalhoub J, Sohaib A, Shun-Shin M, Novak PG, Leather R, Sterns LD, Lane C, Kanagaratnam P, Peters NS, Francis DP, Sikkel MB. Sau A, et al. Among authors: francis dp. Europace. 2019 Aug 1;21(8):1176-1184. doi: 10.1093/europace/euz108. Europace. 2019. PMID: 31071213 Free PMC article.
CONCLUSION: Linear ablation, PWI, and CFAE ablation improves intraprocedural AF termination, but such termination does not predict better long-term outcomes. Study arms including PWI or LAA isolation in the lesion set were associated with improved outcomes in terms of free …
CONCLUSION: Linear ablation, PWI, and CFAE ablation improves intraprocedural AF termination, but such termination does not predict better lo …
Atrioventricular Optimized Direct His Bundle Pacing Improves Acute Hemodynamic Function in Patients With Heart Failure and PR Interval Prolongation Without Left Bundle Branch Block.
Sohaib SMA, Wright I, Lim E, Moore P, Lim PB, Koawing M, Lefroy DC, Lusgarten D, Linton NWF, Davies DW, Peters NS, Kanagaratnam P, Francis DP, Whinnett ZI. Sohaib SMA, et al. Among authors: francis dp. JACC Clin Electrophysiol. 2015 Dec;1(6):582-591. doi: 10.1016/j.jacep.2015.08.008. Epub 2015 Oct 23. JACC Clin Electrophysiol. 2015. PMID: 29759412 Free article.
The improvement is 60% of the effect size previously reported for biventricular pacing in left bundle branch block. Randomized, blinded trials are warranted to test for long-term beneficial effects....
The improvement is 60% of the effect size previously reported for biventricular pacing in left bundle branch block. Randomized, blinded tria …
24 results