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Dementia, infections and vaccines: 30 years of controversy.
Ecarnot F, Boccardi V, Calcagno A, Franceschi C, Fülop T, Itzhaki RF, Michel JP, Panza F, Rainero I, Solfrizzi V, Ticinesi A, Veronese N, Maggi S. Ecarnot F, et al. Among authors: franceschi c. Aging Clin Exp Res. 2023 Jun;35(6):1145-1160. doi: 10.1007/s40520-023-02409-8. Epub 2023 May 9. Aging Clin Exp Res. 2023. PMID: 37160649 Free PMC article. Review.
In conclusion, there is a large body of evidence supporting the involvement of various infectious pathogens in the pathogenesis of dementia, but large-scale studies with long-term follow-up are needed to elucidate the role that infection may play, especially before subclin …
In conclusion, there is a large body of evidence supporting the involvement of various infectious pathogens in the pathogenesis of dementia, …
Long-term human spaceflight and inflammaging: Does it promote aging?
Capri M, Conte M, Ciurca E, Pirazzini C, Garagnani P, Santoro A, Longo F, Salvioli S, Lau P, Moeller R, Jordan J, Illig T, Villanueva MM, Gruber M, Bürkle A, Franceschi C, Rittweger J. Capri M, et al. Among authors: franceschi c. Ageing Res Rev. 2023 Jun;87:101909. doi: 10.1016/j.arr.2023.101909. Epub 2023 Mar 12. Ageing Res Rev. 2023. PMID: 36918115 Free article. Review.
Long-Term Decrease in Coloration: A Consequence of Climate Change?
López-Idiáquez D, Teplitsky C, Grégoire A, Fargevieille A, Del Rey M, de Franceschi C, Charmantier A, Doutrelant C. López-Idiáquez D, et al. Among authors: de franceschi c. Am Nat. 2022 Jul;200(1):32-47. doi: 10.1086/719655. Epub 2022 May 11. Am Nat. 2022. PMID: 35737990
Genetic variance in fitness indicates rapid contemporary adaptive evolution in wild animals.
Bonnet T, Morrissey MB, de Villemereuil P, Alberts SC, Arcese P, Bailey LD, Boutin S, Brekke P, Brent LJN, Camenisch G, Charmantier A, Clutton-Brock TH, Cockburn A, Coltman DW, Courtiol A, Davidian E, Evans SR, Ewen JG, Festa-Bianchet M, de Franceschi C, Gustafsson L, Höner OP, Houslay TM, Keller LF, Manser M, McAdam AG, McLean E, Nietlisbach P, Osmond HL, Pemberton JM, Postma E, Reid JM, Rutschmann A, Santure AW, Sheldon BC, Slate J, Teplitsky C, Visser ME, Wachter B, Kruuk LEB. Bonnet T, et al. Among authors: de franceschi c. Science. 2022 May 27;376(6596):1012-1016. doi: 10.1126/science.abk0853. Epub 2022 May 26. Science. 2022. PMID: 35617403 Free article.
To date, there are few robust estimates of this parameter for natural populations, and it is therefore unclear whether adaptive evolution can play a meaningful role in short-term population dynamics. We developed and applied quantitative genetic methods to long-term …
To date, there are few robust estimates of this parameter for natural populations, and it is therefore unclear whether adaptive evolution ca …
Association between fat-soluble vitamins and self-reported health status: a cross-sectional analysis of the MARK-AGE cohort.
Stokes CS, Weber D, Wagenpfeil S, Stuetz W, Moreno-Villanueva M, Dollé MET, Jansen E, Gonos ES, Bernhardt J, Grubeck-Loebenstein B, Fiegl S, Sikora E, Toussaint O, Debacq-Chainiaux F, Capri M, Hervonen A, Slagboom PE, Breusing N, Frank J, Bürkle A, Franceschi C, Grune T. Stokes CS, et al. Among authors: franceschi c. Br J Nutr. 2022 Aug 14;128(3):433-443. doi: 10.1017/S0007114521004633. Epub 2021 Nov 19. Br J Nutr. 2022. PMID: 34794520 Free PMC article.
Lower vitamin A and D status emerged as independent markers for fair/poor SRH. Further insights into the long-term implications of these modifiable nutrients on health status are warranted....
Lower vitamin A and D status emerged as independent markers for fair/poor SRH. Further insights into the long-term implications of th …
Features of age-related response to sleep deprivation: in vivo experimental studies.
Novozhilova M, Mishchenko T, Kondakova E, Lavrova T, Gavrish M, Aferova S, Franceschi C, Vedunova M. Novozhilova M, et al. Among authors: franceschi c. Aging (Albany NY). 2021 Jul 28;13(15):19108-19126. doi: 10.18632/aging.203372. Epub 2021 Jul 28. Aging (Albany NY). 2021. PMID: 34320466 Free PMC article.
Nevertheless, whether insomnia is actually an age-associated process or whether it acts as an independent stress-factor that activates pathological processes, remains controversial. In this study, we analyzed the effects of long-term sleep deprivation modeling on the locom …
Nevertheless, whether insomnia is actually an age-associated process or whether it acts as an independent stress-factor that activates patho …
Inflammaging in Endemic Areas for Infectious Diseases.
Batista MA, Calvo-Fortes F, Silveira-Nunes G, Camatta GC, Speziali E, Turroni S, Teixeira-Carvalho A, Martins-Filho OA, Neretti N, Maioli TU, Santos RR, Brigidi P, Franceschi C, Faria AMC. Batista MA, et al. Among authors: franceschi c. Front Immunol. 2020 Nov 12;11:579972. doi: 10.3389/fimmu.2020.579972. eCollection 2020. Front Immunol. 2020. PMID: 33262758 Free PMC article. Review.
Inflammatory responses may have a protective effect against these infectious agents. At the same time, the long-term consequences of protective immune responses during chronic infections may result in accelerated immunosenescence in these individuals. ...
Inflammatory responses may have a protective effect against these infectious agents. At the same time, the long-term consequences of …
The conundrum of human immune system "senescence".
Pawelec G, Bronikowski A, Cunnane SC, Ferrucci L, Franceschi C, Fülöp T, Gaudreau P, Gladyshev VN, Gonos ES, Gorbunova V, Kennedy BK, Larbi A, Lemaître JF, Liu GH, Maier AB, Morais JA, Nóbrega OT, Moskalev A, Rikkert MO, Seluanov A, Senior AM, Ukraintseva S, Vanhaelen Q, Witkowski J, Cohen AA. Pawelec G, et al. Among authors: franceschi c. Mech Ageing Dev. 2020 Dec;192:111357. doi: 10.1016/j.mad.2020.111357. Epub 2020 Sep 17. Mech Ageing Dev. 2020. PMID: 32949594 Free PMC article. Review.
Here, we consider what we believe to be the especially confused and confusing case of the ageing of the human immune system, commonly referred to as "immunosenescence". But what exactly is meant by this term? It has been used loosely in the literature, resulting in a certa …
Here, we consider what we believe to be the especially confused and confusing case of the ageing of the human immune system, commonly referr …
A public health perspective of aging: do hyper-inflammatory syndromes such as COVID-19, SARS, ARDS, cytokine storm syndrome, and post-ICU syndrome accelerate short- and long-term inflammaging?
Bektas A, Schurman SH, Franceschi C, Ferrucci L. Bektas A, et al. Among authors: franceschi c. Immun Ageing. 2020 Aug 24;17:23. doi: 10.1186/s12979-020-00196-8. eCollection 2020. Immun Ageing. 2020. PMID: 32849908 Free PMC article.
A central clinical question as the world deals with the COVID-19 pandemic is what the long-term sequelae for the millions of individuals will be who recover from the hyperinflammatory state characterizing COVID-19 and in particular for the hundreds of thousands who are ill …
A central clinical question as the world deals with the COVID-19 pandemic is what the long-term sequelae for the millions of individu …
The preventive strategy for pandemics in the elderly is to collect in advance samples & data to counteract chronic inflammation (inflammaging).
Fuellen G, Liesenfeld O, Kowald A, Barrantes I, Bastian M, Simm A, Jansen L, Tietz-Latza A, Quandt D, Franceschi C, Walter M. Fuellen G, et al. Among authors: franceschi c. Ageing Res Rev. 2020 Sep;62:101091. doi: 10.1016/j.arr.2020.101091. Epub 2020 May 24. Ageing Res Rev. 2020. PMID: 32454090 Free PMC article. Review.
Longitudinal outcome data can then be combined with other epidemics and old-age health data, to discover the best biomarkers to predict (i) coping with infection & inflammation and thus hospitalization or intensive care, (ii) long-term health challenges, e.g. deteriora …
Longitudinal outcome data can then be combined with other epidemics and old-age health data, to discover the best biomarkers to predict (i) …
38 results