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Analysis of seizure-cluster circadian periodicity from a long-term, open-label safety study of diazepam nasal spray.
Fountain NB, Quigg M, Murchison CF, Carrazana E, Rabinowicz AL. Fountain NB, et al. Epilepsia. 2024 Apr;65(4):920-928. doi: 10.1111/epi.17911. Epub 2024 Feb 23. Epilepsia. 2024. PMID: 38391291 Clinical Trial.
However, little is known about the cyclical patterns in seizure clusters. This post hoc analysis of data from a long-term, phase 3, open-label, repeat-dose safety study of diazepam nasal spray modeled the periodicity of treated seizure clusters. ...
However, little is known about the cyclical patterns in seizure clusters. This post hoc analysis of data from a long-term, phase 3, o …
Nine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsy.
Nair DR, Laxer KD, Weber PB, Murro AM, Park YD, Barkley GL, Smith BJ, Gwinn RP, Doherty MJ, Noe KH, Zimmerman RS, Bergey GK, Anderson WS, Heck C, Liu CY, Lee RW, Sadler T, Duckrow RB, Hirsch LJ, Wharen RE Jr, Tatum W, Srinivasan S, McKhann GM, Agostini MA, Alexopoulos AV, Jobst BC, Roberts DW, Salanova V, Witt TC, Cash SS, Cole AJ, Worrell GA, Lundstrom BN, Edwards JC, Halford JJ, Spencer DC, Ernst L, Skidmore CT, Sperling MR, Miller I, Geller EB, Berg MJ, Fessler AJ, Rutecki P, Goldman AM, Mizrahi EM, Gross RE, Shields DC, Schwartz TH, Labar DR, Fountain NB, Elias WJ, Olejniczak PW, Villemarette-Pittman NR, Eisenschenk S, Roper SN, Boggs JG, Courtney TA, Sun FT, Seale CG, Miller KL, Skarpaas TL, Morrell MJ; RNS System LTT Study. Nair DR, et al. Among authors: fountain nb. Neurology. 2020 Sep 1;95(9):e1244-e1256. doi: 10.1212/WNL.0000000000010154. Epub 2020 Jul 20. Neurology. 2020. PMID: 32690786 Free PMC article.
METHODS: Adults treated with brain-responsive neurostimulation in 2-year feasibility or randomized controlled trials were enrolled in a long-term prospective open label trial (LTT) to assess safety, efficacy, and quality of life (QOL) over an additional 7 years. ...
METHODS: Adults treated with brain-responsive neurostimulation in 2-year feasibility or randomized controlled trials were enrolled in a long …
Electrocorticographic events from long-term ambulatory brain recordings can potentially supplement seizure diaries.
Quigg M, Skarpaas TL, Spencer DC, Fountain NB, Jarosiewicz B, Morrell MJ. Quigg M, et al. Among authors: fountain nb. Epilepsy Res. 2020 Mar;161:106302. doi: 10.1016/j.eplepsyres.2020.106302. Epub 2020 Feb 24. Epilepsy Res. 2020. PMID: 32126490 Free article.
METHODS: Data were retrospectively analyzed from a randomized controlled trial of brain-responsive neurostimulation (RNS System) for adjunctive treatment of medically intractable focal onset seizures in 191 subjects. The long-term (3 months) correspondence between daily co …
METHODS: Data were retrospectively analyzed from a randomized controlled trial of brain-responsive neurostimulation (RNS System) for adjunct …
Indications and methodology for video-electroencephalographic studies in the epilepsy monitoring unit.
Shih JJ, Fountain NB, Herman ST, Bagic A, Lado F, Arnold S, Zupanc ML, Riker E, Labiner DM. Shih JJ, et al. Among authors: fountain nb. Epilepsia. 2018 Jan;59(1):27-36. doi: 10.1111/epi.13938. Epub 2017 Nov 10. Epilepsia. 2018. PMID: 29124760 Review.
General neurologists, hospital administrators, and insurers also have yet to fully understand the role this type of testing has in the diagnosis and management of individuals with paroxysmal neurologic symptoms. This review outlines the indications for long-term video-elec …
General neurologists, hospital administrators, and insurers also have yet to fully understand the role this type of testing has in the diagn …
Brain-responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy.
Geller EB, Skarpaas TL, Gross RE, Goodman RR, Barkley GL, Bazil CW, Berg MJ, Bergey GK, Cash SS, Cole AJ, Duckrow RB, Edwards JC, Eisenschenk S, Fessler J, Fountain NB, Goldman AM, Gwinn RP, Heck C, Herekar A, Hirsch LJ, Jobst BC, King-Stephens D, Labar DR, Leiphart JW, Marsh WR, Meador KJ, Mizrahi EM, Murro AM, Nair DR, Noe KH, Park YD, Rutecki PA, Salanova V, Sheth RD, Shields DC, Skidmore C, Smith MC, Spencer DC, Srinivasan S, Tatum W, Van Ness PC, Vossler DG, Wharen RE Jr, Worrell GA, Yoshor D, Zimmerman RS, Cicora K, Sun FT, Morrell MJ. Geller EB, et al. Among authors: fountain nb. Epilepsia. 2017 Jun;58(6):994-1004. doi: 10.1111/epi.13740. Epub 2017 Apr 11. Epilepsia. 2017. PMID: 28398014 Free article. Clinical Trial.
Circadian and ultradian patterns of epileptiform discharges differ by seizure-onset location during long-term ambulatory intracranial monitoring.
Spencer DC, Sun FT, Brown SN, Jobst BC, Fountain NB, Wong VS, Mirro EA, Quigg M. Spencer DC, et al. Among authors: fountain nb. Epilepsia. 2016 Sep;57(9):1495-502. doi: 10.1111/epi.13455. Epub 2016 Jul 11. Epilepsia. 2016. PMID: 27396544 Free article.
OBJECTIVE: Previous studies reporting circadian patterns of epileptiform activity and seizures are limited by (1) short-term recording in an epilepsy monitoring unit (EMU) with altered antiepileptic drugs (AEDs) and sleep, or (2) subjective seizure diary reports. We studie …
OBJECTIVE: Previous studies reporting circadian patterns of epileptiform activity and seizures are limited by (1) short-term recordin …
Long-term efficacy and safety of thalamic stimulation for drug-resistant partial epilepsy.
Salanova V, Witt T, Worth R, Henry TR, Gross RE, Nazzaro JM, Labar D, Sperling MR, Sharan A, Sandok E, Handforth A, Stern JM, Chung S, Henderson JM, French J, Baltuch G, Rosenfeld WE, Garcia P, Barbaro NM, Fountain NB, Elias WJ, Goodman RR, Pollard JR, Tröster AI, Irwin CP, Lambrecht K, Graves N, Fisher R; SANTE Study Group. Salanova V, et al. Among authors: fountain nb. Neurology. 2015 Mar 10;84(10):1017-25. doi: 10.1212/WNL.0000000000001334. Epub 2015 Feb 6. Neurology. 2015. PMID: 25663221 Free PMC article. Clinical Trial.
METHODS: This long-term follow-up is a continuation of a previously reported trial of 5- vs 0-V ANT stimulation. Long-term follow-up began 13 months after device implantation with stimulation parameters adjusted at the investigators' discretion. ...
METHODS: This long-term follow-up is a continuation of a previously reported trial of 5- vs 0-V ANT stimulation. Long-term fol …
Safety and efficacy of adjunctive lacosamide among patients with partial-onset seizures in a long-term open-label extension trial of up to 8 years.
Rosenfeld W, Fountain NB, Kaubrys G, Ben-Menachem E, McShea C, Isojarvi J, Doty P; SP615 Study Investigators. Rosenfeld W, et al. Among authors: fountain nb. Epilepsy Behav. 2014 Dec;41:164-70. doi: 10.1016/j.yebeh.2014.09.074. Epub 2014 Oct 27. Epilepsy Behav. 2014. PMID: 25461210 Clinical Trial.
Long-term (up to 8 years of exposure) safety and efficacy of the antiepileptic drug lacosamide was evaluated in this open-label extension trial (SP615 [ClinicalTrials.gov identifier: NCT00552305]). ...
Long-term (up to 8 years of exposure) safety and efficacy of the antiepileptic drug lacosamide was evaluated in this open-label exten …
Status epilepticus: risk factors and complications.
Fountain NB. Fountain NB. Epilepsia. 2000;41 Suppl 2:S23-30. doi: 10.1111/j.1528-1157.2000.tb01521.x. Epilepsia. 2000. PMID: 10885737 Free article. Review.
Acute complications result from hyperthermia, pulmonary edema, cardiac arrhythmias, and cardiovascular collapse. Long-term complications include epilepsy (20% to 40%), encephalopathy (6% to 15%), and focal neurologic deficits (9% to 11%). ...
Acute complications result from hyperthermia, pulmonary edema, cardiac arrhythmias, and cardiovascular collapse. Long-term complicati …