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L. rhamnosus improves the immune response and tryptophan catabolism in laying hen pullets.
Mindus C, van Staaveren N, Fuchs D, Gostner JM, Kjaer JB, Kunze W, Mian MF, Shoveller AK, Forsythe P, Harlander-Matauschek A. Mindus C, et al. Among authors: forsythe p. Sci Rep. 2021 Oct 1;11(1):19538. doi: 10.1038/s41598-021-98459-x. Sci Rep. 2021. PMID: 34599202 Free PMC article.
Consequently, we investigated whether early-life, oral supplementation with a single Lactobacillus rhamnosus strain can prevent stress-induced feather-pecking behaviour in chickens. To this end, we monitored both the short- and long-term effects of the probiotic supplement …
Consequently, we investigated whether early-life, oral supplementation with a single Lactobacillus rhamnosus strain can prevent stress-induc …
Sex dependent effects of post-natal penicillin on brain, behavior and immune regulation are prevented by concurrent probiotic treatment.
Kayyal M, Javkar T, Firoz Mian M, Binyamin D, Koren O, McVey Neufeld KA, Forsythe P. Kayyal M, et al. Among authors: forsythe p. Sci Rep. 2020 Jun 25;10(1):10318. doi: 10.1038/s41598-020-67271-4. Sci Rep. 2020. PMID: 32587382 Free PMC article.
We demonstrated that exposure to the antibiotic during the pre-weaning period led to long-term changes in social behaviour, but not anxiety-like traits, in male mice only. ...Our study indicates that post-natal exposure to a clinically relevant dose of antibiotic has long- …
We demonstrated that exposure to the antibiotic during the pre-weaning period led to long-term changes in social behaviour, but not a …
The vagus nerve is necessary for the rapid and widespread neuronal activation in the brain following oral administration of psychoactive bacteria.
Bharwani A, West C, Champagne-Jorgensen K, McVey Neufeld KA, Ruberto J, Kunze WA, Bienenstock J, Forsythe P. Bharwani A, et al. Among authors: forsythe p. Neuropharmacology. 2020 Jun 15;170:108067. doi: 10.1016/j.neuropharm.2020.108067. Epub 2020 Mar 26. Neuropharmacology. 2020. PMID: 32224131
These data identify that specific brain regions respond rapidly to gut microbes via vagal-dependent and independent pathways, and demonstrate that acute versus long-term exposure is associated with differential responses in distinct brain regions....
These data identify that specific brain regions respond rapidly to gut microbes via vagal-dependent and independent pathways, and demonstrat …
Oral selective serotonin reuptake inhibitors activate vagus nerve dependent gut-brain signalling.
McVey Neufeld KA, Bienenstock J, Bharwani A, Champagne-Jorgensen K, Mao Y, West C, Liu Y, Surette MG, Kunze W, Forsythe P. McVey Neufeld KA, et al. Among authors: forsythe p. Sci Rep. 2019 Oct 3;9(1):14290. doi: 10.1038/s41598-019-50807-8. Sci Rep. 2019. PMID: 31582799 Free PMC article.
The vagus nerve can transmit signals to the brain resulting in a reduction in depressive behavior as evidenced by the long-term beneficial effects of electrical stimulation of the vagus in patients with intractable depression. ...
The vagus nerve can transmit signals to the brain resulting in a reduction in depressive behavior as evidenced by the long-term benef …
Caring about Preemies' Safe Sleep (CaPSS): An Educational Program to Improve Adherence to Safe Sleep Recommendations by Mothers of Preterm Infants.
Dowling DA, Barsman SG, Forsythe P, Damato EG. Dowling DA, et al. Among authors: forsythe p. J Perinat Neonatal Nurs. 2018 Oct/Dec;32(4):366-372. doi: 10.1097/JPN.0000000000000345. J Perinat Neonatal Nurs. 2018. PMID: 29939882
Preterm infants born before 37 weeks' gestation die of sudden infant death syndrome (SIDS) at a rate more than double that of term infants. There is a need for SIDS prevention programs tailored to the specific needs of parents of high-risk infants. ...
Preterm infants born before 37 weeks' gestation die of sudden infant death syndrome (SIDS) at a rate more than double that of term in …
Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior.
Leclercq S, Mian FM, Stanisz AM, Bindels LB, Cambier E, Ben-Amram H, Koren O, Forsythe P, Bienenstock J. Leclercq S, et al. Among authors: forsythe p. Nat Commun. 2017 Apr 4;8:15062. doi: 10.1038/ncomms15062. Nat Commun. 2017. PMID: 28375200 Free PMC article.
There is increasing concern about potential long-term effects of antibiotics on children's health. Epidemiological studies have revealed that early-life antibiotic exposure can increase the risk of developing immune and metabolic diseases, and rodent studies have shown tha …
There is increasing concern about potential long-term effects of antibiotics on children's health. Epidemiological studies have revea …
Moody microbes or fecal phrenology: what do we know about the microbiota-gut-brain axis?
Forsythe P, Kunze W, Bienenstock J. Forsythe P, et al. BMC Med. 2016 Apr 19;14:58. doi: 10.1186/s12916-016-0604-8. BMC Med. 2016. PMID: 27090095 Free PMC article.
INTRODUCTION: The microbiota-gut-brain axis is a term that is commonly used and covers a broad set of functions and interactions between the gut microbiome, endocrine, immune and nervous systems and the brain. ...
INTRODUCTION: The microbiota-gut-brain axis is a term that is commonly used and covers a broad set of functions and interactions betw …
Mucosal exposure to cockroach extract induces allergic sensitization and allergic airway inflammation.
Arizmendi NG, Abel M, Puttagunta L, Asaduzzaman M, Davidson C, Karimi K, Forsythe P, Vliagoftis H. Arizmendi NG, et al. Among authors: forsythe p. Allergy Asthma Clin Immunol. 2011 Dec 14;7(1):22. doi: 10.1186/1710-1492-7-22. Allergy Asthma Clin Immunol. 2011. PMID: 22168152 Free PMC article.
RESULTS: Mucosal exposure of Balb/c mice to cockroach extract induced airway eosinophilic inflammation, AHR and cockroach-specific IgG1; however, AHR to methacholine was absent in the long term group. Lung histology showed patchy, multicentric damage with inflammatory infi …
RESULTS: Mucosal exposure of Balb/c mice to cockroach extract induced airway eosinophilic inflammation, AHR and cockroach-specific IgG1; how …
Opposing effects of short- and long-term stress on airway inflammation.
Forsythe P, Ebeling C, Gordon JR, Befus AD, Vliagoftis H. Forsythe P, et al. Am J Respir Crit Care Med. 2004 Jan 15;169(2):220-6. doi: 10.1164/rccm.200307-979OC. Epub 2003 Nov 6. Am J Respir Crit Care Med. 2004. PMID: 14604839
After short-term stress, inflammatory cell number was decreased compared with unstressed animals, whereas levels of interleukin (IL)-6, IL-9, and IL-13 were increased. ...Our results indicate that repeated exposure to stress over the long term engages different mech …
After short-term stress, inflammatory cell number was decreased compared with unstressed animals, whereas levels of interleukin (IL)- …