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Hemoadsorption: Consensus report of the 30th Acute Disease Quality Initiative workgroup.
Ankawi G, Bagshaw SM, Bellomo R, Baldwin I, Basu R, Bottari G, Cantaluppi V, Clark W, De Rosa S, Forni LG, Fuhrman D, Goldstein S, Gomez H, Husain-Syed F, Joannidis M, Kashani K, Lorenzin A, Mehta R, Murray PT, Murugan R, Ostermann M, Pannu N, Premuzic V, Prowle J, Reis T, Rimmelé T, Ronco C, Rosner M, Schneider A, See E, Soranno D, Villa G, Whaley-Connell A, Zarbock A. Ankawi G, et al. Among authors: forni lg. Nephrol Dial Transplant. 2024 Apr 15:gfae089. doi: 10.1093/ndt/gfae089. Online ahead of print. Nephrol Dial Transplant. 2024. PMID: 38621759
The data show that hemoadsorption has clinically acceptable short-term biocompatibility and safety, technical feasibility, and experimental demonstration of specified target molecule removal. ...
The data show that hemoadsorption has clinically acceptable short-term biocompatibility and safety, technical feasibility, and experi …
Subphenotypes of acute kidney injury in adults.
Vaara ST, Forni LG, Joannidis M. Vaara ST, et al. Among authors: forni lg. Curr Opin Crit Care. 2022 Dec 1;28(6):599-604. doi: 10.1097/MCC.0000000000000970. Epub 2022 Aug 4. Curr Opin Crit Care. 2022. PMID: 35942680 Review.
SUMMARY: Subphenotyping may help reduce heterogeneity under the umbrella term of acute kidney injury. Despite challenges remain, the identification of AKI subphenotypes has opened the potential of AKI research focused on better targeted therapies....
SUMMARY: Subphenotyping may help reduce heterogeneity under the umbrella term of acute kidney injury. Despite challenges remain, the …
Safety and Feasibility Assessment of Repetitive Vascular Occlusion Stimulus (RVOS) Application to Multi-Organ Failure Critically Ill Patients: A Pilot Randomised Controlled Trial.
Chhetri I, Hunt JEA, Mendis JR, Forni LG, Kirk-Bayley J, White I, Cooper J, Somasundaram K, Shah N, Patterson SD, Puthucheary ZA, Montgomery HE, Creagh-Brown BC. Chhetri I, et al. Among authors: forni lg. J Clin Med. 2022 Jul 6;11(14):3938. doi: 10.3390/jcm11143938. J Clin Med. 2022. PMID: 35887701 Free PMC article.
Muscle wasting is implicated in the pathogenesis of intensive care unit acquired weakness (ICU-AW), affecting 40% of patients and causing long-term physical disability. A repetitive vascular occlusion stimulus (RVOS) limits muscle atrophy in healthy and orthopaedic subject …
Muscle wasting is implicated in the pathogenesis of intensive care unit acquired weakness (ICU-AW), affecting 40% of patients and causing lo …
Postoperative acute kidney injury in adult non-cardiac surgery: joint consensus report of the Acute Disease Quality Initiative and PeriOperative Quality Initiative.
Prowle JR, Forni LG, Bell M, Chew MS, Edwards M, Grams ME, Grocott MPW, Liu KD, McIlroy D, Murray PT, Ostermann M, Zarbock A, Bagshaw SM, Bartz R, Bell S, Bihorac A, Gan TJ, Hobson CE, Joannidis M, Koyner JL, Levett DZH, Mehta RL, Miller TE, Mythen MG, Nadim MK, Pearse RM, Rimmele T, Ronco C, Shaw AD, Kellum JA. Prowle JR, et al. Among authors: forni lg. Nat Rev Nephrol. 2021 Sep;17(9):605-618. doi: 10.1038/s41581-021-00418-2. Epub 2021 May 11. Nat Rev Nephrol. 2021. PMID: 33976395 Free PMC article. Review.
Postoperative acute kidney injury (PO-AKI) is a common complication of major surgery that is strongly associated with short-term surgical complications and long-term adverse outcomes, including increased risk of chronic kidney disease, cardiovascular events and deat …
Postoperative acute kidney injury (PO-AKI) is a common complication of major surgery that is strongly associated with short-term surg …
COVID-19 infection and the kidney.
Alvarez-Belon L, Sarnowski A, Forni LG. Alvarez-Belon L, et al. Among authors: forni lg. Br J Hosp Med (Lond). 2020 Oct 2;81(10):1-8. doi: 10.12968/hmed.2020.0574. Epub 2020 Oct 6. Br J Hosp Med (Lond). 2020. PMID: 33135911 Review.
Treatment is, in the main, supportive, with kidney replacement therapy required in nearly 25% of reported cases. Few data currently exist as to the long-term burden of COVID-19-associated acute kidney injury but evidence suggests that only approximately one-third of patien …
Treatment is, in the main, supportive, with kidney replacement therapy required in nearly 25% of reported cases. Few data currently exist as …
Use of Cell Cycle Arrest Biomarkers in Conjunction With Classical Markers of Acute Kidney Injury.
Joannidis M, Forni LG, Haase M, Koyner J, Shi J, Kashani K, Chawla LS, Kellum JA; Sapphire Investigators. Joannidis M, et al. Among authors: forni lg. Crit Care Med. 2019 Oct;47(10):e820-e826. doi: 10.1097/CCM.0000000000003907. Crit Care Med. 2019. PMID: 31343478 Free PMC article.
CONCLUSIONS: Cell cycle arrest biomarkers, TIMP-2 and IGFBP7, improve risk stratification for severe outcomes in patients with stage 1 acute kidney injury by urine output, serum creatinine or both, with risk increasing with each acute kidney injury indicator. Longer term o …
CONCLUSIONS: Cell cycle arrest biomarkers, TIMP-2 and IGFBP7, improve risk stratification for severe outcomes in patients with stage 1 acute …
Quality Improvement Goals for Acute Kidney Injury.
Kashani K, Rosner MH, Haase M, Lewington AJP, O'Donoghue DJ, Wilson FP, Nadim MK, Silver SA, Zarbock A, Ostermann M, Mehta RL, Kane-Gill SL, Ding X, Pickkers P, Bihorac A, Siew ED, Barreto EF, Macedo E, Kellum JA, Palevsky PM, Tolwani AJ, Ronco C, Juncos LA, Rewa OG, Bagshaw SM, Mottes TA, Koyner JL, Liu KD, Forni LG, Heung M, Wu VC. Kashani K, et al. Among authors: forni lg. Clin J Am Soc Nephrol. 2019 Jun 7;14(6):941-953. doi: 10.2215/CJN.01250119. Epub 2019 May 17. Clin J Am Soc Nephrol. 2019. PMID: 31101671 Free PMC article.
Improving the quality of care provided to these patients, plausibly mitigating the cost of care and improving short- and long-term outcomes, are goals that have not been universally achieved. ...
Improving the quality of care provided to these patients, plausibly mitigating the cost of care and improving short- and long-term ou …
Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury: A Randomized Clinical Trial.
Pickkers P, Mehta RL, Murray PT, Joannidis M, Molitoris BA, Kellum JA, Bachler M, Hoste EAJ, Hoiting O, Krell K, Ostermann M, Rozendaal W, Valkonen M, Brealey D, Beishuizen A, Meziani F, Murugan R, de Geus H, Payen D, van den Berg E, Arend J; STOP-AKI Investigators. Pickkers P, et al. JAMA. 2018 Nov 20;320(19):1998-2009. doi: 10.1001/jama.2018.14283. JAMA. 2018. PMID: 30357272 Free PMC article. Clinical Trial.
IMPORTANCE: Sepsis-associated acute kidney injury (AKI) adversely affects long-term kidney outcomes and survival. Administration of the detoxifying enzyme alkaline phosphatase may improve kidney function and survival. ...CONCLUSIONS AND RELEVANCE: Among patients who were c …
IMPORTANCE: Sepsis-associated acute kidney injury (AKI) adversely affects long-term kidney outcomes and survival. Administration of t …
Acute kidney injury associated with endurance events-is it a cause for concern? A systematic review.
Hodgson LE, Walter E, Venn RM, Galloway R, Pitsiladis Y, Sardat F, Forni LG. Hodgson LE, et al. Among authors: forni lg. BMJ Open Sport Exerc Med. 2017 Jun 14;3(1):e000093. doi: 10.1136/bmjsem-2015-000093. eCollection 2017. BMJ Open Sport Exerc Med. 2017. PMID: 29259804 Free PMC article.
Rises in biomarkers suggest potential parenchymal insult, rather than simply muscle breakdown. However, evidence of long-term deleterious effects is lacking. CONCLUSIONS: Raised levels of SCr are reported immediately after endurance events. ...On-site biochemistry, urine a …
Rises in biomarkers suggest potential parenchymal insult, rather than simply muscle breakdown. However, evidence of long-term deleter …
Renal recovery after acute kidney injury.
Forni LG, Darmon M, Ostermann M, Oudemans-van Straaten HM, Pettilä V, Prowle JR, Schetz M, Joannidis M. Forni LG, et al. Intensive Care Med. 2017 Jun;43(6):855-866. doi: 10.1007/s00134-017-4809-x. Epub 2017 May 2. Intensive Care Med. 2017. PMID: 28466146 Free PMC article. Review.
Acute kidney injury (AKI) is a frequent complication of critical illness and carries a significant risk of short- and long-term mortality, chronic kidney disease (CKD) and cardiovascular events. The degree of renal recovery from AKI may substantially affect these long-t …
Acute kidney injury (AKI) is a frequent complication of critical illness and carries a significant risk of short- and long-term morta …
16 results