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miRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity.
Welle TM, Rajgor D, Garcia JD, Kareemo D, Zych SM, Gookin SE, Martinez TP, Dell'Acqua ML, Ford CP, Kennedy MJ, Smith KR. Welle TM, et al. Among authors: ford cp. bioRxiv [Preprint]. 2023 Dec 12:2023.12.12.570420. doi: 10.1101/2023.12.12.570420. bioRxiv. 2023. PMID: 38168421 Free PMC article. Preprint.
However, our understanding of the translational mechanisms controlling inhibitory synapses is limited. One distinct form of inhibitory long-term potentiation (iLTP) enhances postsynaptic clusters of GABA(A)Rs and the primary inhibitory scaffold, gephyrin, to promote sustai …
However, our understanding of the translational mechanisms controlling inhibitory synapses is limited. One distinct form of inhibitory long- …
Integration, effectiveness and costs of different models of primary health care provision for people who are homeless: an evaluation study.
Crane M, Joly L, Daly BJ, Gage H, Manthorpe J, Cetrano G, Ford C, Williams P. Crane M, et al. Among authors: ford c. Health Soc Care Deliv Res. 2023 Oct;11(16):1-217. doi: 10.3310/WXUW5103. Health Soc Care Deliv Res. 2023. PMID: 37839804
OBJECTIVES: This study evaluated the work of different models of primary health care provision in England to determine their effectiveness in engaging people who are homeless in health care and in providing continuity of care for long-term conditions. It concerned single p …
OBJECTIVES: This study evaluated the work of different models of primary health care provision in England to determine their effectiveness i …
Central Sleep Apnea in Adults: Diagnosis and Treatment.
Regn DD, Davis AH, Smith WD, Blasser CJ, Ford CM. Regn DD, et al. Among authors: ford cm. Fed Pract. 2023 Mar;40(3):78-86. doi: 10.12788/fp.0367. Epub 2023 Mar 9. Fed Pract. 2023. PMID: 37228430 Free PMC article.
BACKGROUND: While the literature has demonstrated a higher prevalence of moderate-to-severe obstructive sleep apnea (OSA) in the general population compared with central sleep apnea (CSA), more evidence is needed on the long-term clinical impact of and optimal treatment st …
BACKGROUND: While the literature has demonstrated a higher prevalence of moderate-to-severe obstructive sleep apnea (OSA) in the general pop …
Potentially More Out of Reach: Public Reporting Exacerbates Inequities in Home Health Access.
Fashaw-Walters SA, Rahman M, Gee G, Mor V, Rivera-Hernandez M, Ford C, Thomas KS. Fashaw-Walters SA, et al. Among authors: ford c. Milbank Q. 2023 Jun;101(2):527-559. doi: 10.1111/1468-0009.12616. Epub 2023 Mar 24. Milbank Q. 2023. PMID: 36961089
CONTEXT: Literature suggests that public reporting of quality may have the unintended consequence of exacerbating disparities in access to high-quality, long-term care for older adults. The objective of this study is to evaluate the impact of the home health five-star rati …
CONTEXT: Literature suggests that public reporting of quality may have the unintended consequence of exacerbating disparities in access to h …
Targeting Homologous Recombination Deficiency in Ovarian Cancer with PARP Inhibitors: Synthetic Lethal Strategies That Impact Overall Survival.
Xie T, Dickson KA, Yee C, Ma Y, Ford CE, Bowden NA, Marsh DJ. Xie T, et al. Among authors: ford ce. Cancers (Basel). 2022 Sep 23;14(19):4621. doi: 10.3390/cancers14194621. Cancers (Basel). 2022. PMID: 36230543 Free PMC article. Review.
Despite the major advances that PARPis have heralded for women with ovarian cancer, questions and challenges remain, including: can the benefits of PARPis be brought to a wider range of women with ovarian cancer; can other drugs in clinical use function in a similar way or with g …
Despite the major advances that PARPis have heralded for women with ovarian cancer, questions and challenges remain, including: can the bene …
Properties and modulation of excitatory inputs to the locus coeruleus.
Barcomb K, Olah SS, Kennedy MJ, Ford CP. Barcomb K, et al. Among authors: ford cp. J Physiol. 2022 Nov;600(22):4897-4916. doi: 10.1113/JP283605. Epub 2022 Oct 13. J Physiol. 2022. PMID: 36156249 Free PMC article.
While PFC was predicted to make synaptic inputs, we found that the LH and PAG also drove robust excitatory events in LC noradrenaline neurons. The strength, kinetics, and short-term plasticity of each input differed as did the extent of neuromodulation by both dynorphin an …
While PFC was predicted to make synaptic inputs, we found that the LH and PAG also drove robust excitatory events in LC noradrenaline neuron …
Early versus delayed treatment with glatiramer acetate: Analysis of up to 27 years of continuous follow-up in a US open-label extension study.
Ford CC, Cohen JA, Goodman AD, Lindsey JW, Lisak RP, Luzzio C, Pruitt A, Rose J, Rus H, Wolinsky JS, Kadosh SE, Bernstein-Hanlon E, Stark Y, Alexander JK. Ford CC, et al. Mult Scler. 2022 Oct;28(11):1729-1743. doi: 10.1177/13524585221094239. Epub 2022 Jun 29. Mult Scler. 2022. PMID: 35768939 Free PMC article. Clinical Trial.
BACKGROUND: Glatiramer acetate (GA) is US-approved for relapsing multiple sclerosis. OBJECTIVES: To describe GA long-term clinical profile. To compare effectiveness of early start (ES) versus delayed start (DS; up to 3 years) with GA. ...ES prolonged time-to-6-month confir …
BACKGROUND: Glatiramer acetate (GA) is US-approved for relapsing multiple sclerosis. OBJECTIVES: To describe GA long-term clinical pr …
Circulating cell-free DNA undergoes significant decline in yield after prolonged storage time in both plasma and purified form.
Yuwono NL, Boyd MAA, Henry CE, Werner B, Ford CE, Warton K. Yuwono NL, et al. Among authors: ford ce. Clin Chem Lab Med. 2022 May 31;60(8):1287-1298. doi: 10.1515/cclm-2021-1152. Print 2022 Jul 26. Clin Chem Lab Med. 2022. PMID: 35643514
OBJECTIVES: Circulating DNA (cirDNA) is generally purified from plasma that has been biobanked for variable lengths of time. In long-term experiments or clinical trials, the plasma can be stored frozen for up to several years. ...Additionally, cirDNA yield was impacted by …
OBJECTIVES: Circulating DNA (cirDNA) is generally purified from plasma that has been biobanked for variable lengths of time. In long-term …
Sustained immunotolerance in multiple sclerosis after stem cell transplant.
Visweswaran M, Hendrawan K, Massey JC, Khoo ML, Ford CD, Zaunders JJ, Withers B, Sutton IJ, Ma DDF, Moore JJ. Visweswaran M, et al. Among authors: ford cd. Ann Clin Transl Neurol. 2022 Feb;9(2):206-220. doi: 10.1002/acn3.51510. Epub 2022 Feb 1. Ann Clin Transl Neurol. 2022. PMID: 35106961 Free PMC article. Clinical Trial.
However, the mechanisms associated with durable treatment responses in MS require further elucidation. METHODS: To characterise the longer term immune reconstitution effects of AHSCT at 24 and 36 months (M) post-transplant, high-dimensional immunophenotyping of peripheral …
However, the mechanisms associated with durable treatment responses in MS require further elucidation. METHODS: To characterise the longer …
90 results