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Two-year results of tapered dupilumab for CRSwNP demonstrates enduring efficacy established in the first 6 months.
van der Lans RJL, Otten JJ, Adriaensen GFJPM, Hoven DR, Benoist LB, Fokkens WJ, Reitsma S. van der Lans RJL, et al. Among authors: fokkens wj. Allergy. 2023 Oct;78(10):2684-2697. doi: 10.1111/all.15796. Epub 2023 Jul 2. Allergy. 2023. PMID: 37394895
BACKGROUND: Dupilumab is an anti-T2-inflammatory biological registered for chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP), indicated by integrated CRS-care pathways when optimal medico-surgical treatment yields insufficient CRS control. This study aims to evaluate long- …
BACKGROUND: Dupilumab is an anti-T2-inflammatory biological registered for chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP), indicate …
Real-world data using mHealth apps in rhinitis, rhinosinusitis and their multimorbidities.
Sousa-Pinto B, Anto A, Berger M, Dramburg S, Pfaar O, Klimek L, Jutel M, Czarlewski W, Bedbrook A, Valiulis A, Agache I, Amaral R, Ansotegui IJ, Bastl K, Berger U, Bergmann KC, Bosnic-Anticevich S, Braido F, Brussino L, Cardona V, Casale T, Canonica GW, Cecchi L, Charpin D, Chivato T, Chu DK, Cingi C, Costa EM, Cruz AA, Devillier P, Durham SR, Ebisawa M, Fiocchi A, Fokkens WJ, Gemicioğlu B, Gotua M, Guzmán MA, Haahtela T, Ivancevich JC, Kuna P, Kaidashev I, Khaitov M, Kvedariene V, Larenas-Linnemann DE, Lipworth B, Laune D, Matricardi PM, Morais-Almeida M, Mullol J, Naclerio R, Neffen H, Nekam K, Niedoszytko M, Okamoto Y, Papadopoulos NG, Park HS, Passalacqua G, Patella V, Pelosi S, Pham-Thi N, Popov TA, Regateiro FS, Reitsma S, Rodriguez-Gonzales M, Rosario N, Rouadi PW, Samolinski B, Sá-Sousa A, Sastre J, Sheikh A, Ulrik CS, Taborda-Barata L, Todo-Bom A, Tomazic PV, Toppila-Salmi S, Tripodi S, Tsiligianni I, Valovirta E, Ventura MT, Valero AA, Vieira RJ, Wallace D, Waserman S, Williams S, Yorgancioglu A, Zhang L, Zidarn M, Zuberbier J, Olze H, Antó JM, Zuberbier T, Fonseca JA, Bousquet J. Sousa-Pinto B, et al. Among authors: fokkens wj. Clin Transl Allergy. 2022 Nov;12(11):e12208. doi: 10.1002/clt2.12208. Clin Transl Allergy. 2022. PMID: 36434742 Free PMC article.
Digital health is an umbrella term which encompasses eHealth and benefits from areas such as advanced computer sciences. eHealth includes mHealth apps, which offer the potential to redesign aspects of healthcare delivery. ...
Digital health is an umbrella term which encompasses eHealth and benefits from areas such as advanced computer sciences. eHealth incl …
Updates in biologic therapy for chronic rhinosinusitis with nasal polyps and NSAID-exacerbated respiratory disease.
Xu X, Reitsma S, Wang Y, Fokkens WJ. Xu X, et al. Among authors: fokkens wj. Allergy. 2022 Dec;77(12):3593-3605. doi: 10.1111/all.15507. Epub 2022 Sep 15. Allergy. 2022. PMID: 36067036 Review.
Moving forward, direct comparisons among biologicals, refining patient selection criteria for specific biologicals, determining optimal treatment duration and monitoring long-term outcomes are areas of emerging interest. This review summarizes the clinical evidence from th …
Moving forward, direct comparisons among biologicals, refining patient selection criteria for specific biologicals, determining optimal trea …
Endoscopic sinus surgery with medical therapy versus medical therapy for chronic rhinosinusitis with nasal polyps: a multicentre, randomised, controlled trial.
Lourijsen ES, Reitsma S, Vleming M, Hannink G, Adriaensen GFJPM, Cornet ME, Hoven DR, Videler WJM, Bretschneider JH, Reinartz SM, Rovers MM, Fokkens WJ. Lourijsen ES, et al. Among authors: fokkens wj. Lancet Respir Med. 2022 Apr;10(4):337-346. doi: 10.1016/S2213-2600(21)00457-4. Epub 2022 Jan 7. Lancet Respir Med. 2022. PMID: 35012708 Clinical Trial.
INTERPRETATION: ESS plus medical therapy is more efficacious than medical therapy alone in patients with CRSwNP, although the minimal clinically important difference was not met. Long-term follow-up data are needed to determine whether the effect persists. ...
INTERPRETATION: ESS plus medical therapy is more efficacious than medical therapy alone in patients with CRSwNP, although the minimal clinic …
Rhinology in review: from COVID-19 to biologicals.
Fokkens WJ, Landis BN, Hopkins C, Reitsma S, Sedaghat AR. Fokkens WJ, et al. Rhinology. 2021 Dec 1;59(6):490-500. doi: 10.4193/Rhin21.424. Rhinology. 2021. PMID: 34812433 Review.
A large body of evidence now demonstrates loss of sense of smell to be one of the most common symptoms of COVID-19 infection; a meta-analysis of 3563 patients found the mean prevalence of self-reported loss to be 47%. A number of studies have now shown long-term reduced lo …
A large body of evidence now demonstrates loss of sense of smell to be one of the most common symptoms of COVID-19 infection; a meta-analysi …
Long-term antibiotics for Chronic Rhinosinusitis: changing views.
Fokkens WJ. Fokkens WJ. Rhinology. 2019 Aug 1;57(4):241. doi: 10.4193/Rhin19.404. Rhinology. 2019. PMID: 31374113
Based on data from Asia showing the positive effect of long-term antibiotics in diffuse panbronchiolitis, a number of studies have been performed on the effect of long-term macrolides on symptomatology of chronic rhinosinusitis. ...
Based on data from Asia showing the positive effect of long-term antibiotics in diffuse panbronchiolitis, a number of studies have be …
Positioning the principles of precision medicine in care pathways for allergic rhinitis and chronic rhinosinusitis - A EUFOREA-ARIA-EPOS-AIRWAYS ICP statement.
Hellings PW, Fokkens WJ, Bachert C, Akdis CA, Bieber T, Agache I, Bernal-Sprekelsen M, Canonica GW, Gevaert P, Joos G, Lund V, Muraro A, Onerci M, Zuberbier T, Pugin B, Seys SF, Bousquet J; ARIA and EPOS working groups. Hellings PW, et al. Among authors: fokkens wj. Allergy. 2017 Sep;72(9):1297-1305. doi: 10.1111/all.13162. Epub 2017 May 21. Allergy. 2017. PMID: 28306159 Free article.
The second-level approach ideally involves strategies to prevent progression of disease, in addition to prediction of success of therapy, and patient participation in the long-term therapeutic strategy. Endotype-driven treatment is part of a personalized approach and shoul …
The second-level approach ideally involves strategies to prevent progression of disease, in addition to prediction of success of therapy, an …
Endoscopic sinus surgery in adult patients with chronic rhinosinusitis with nasal polyps (PolypESS): study protocol for a randomised controlled trial.
Lourijsen ES, de Borgie CA, Vleming M, Fokkens WJ. Lourijsen ES, et al. Among authors: fokkens wj. Trials. 2017 Jan 23;18(1):39. doi: 10.1186/s13063-016-1728-z. Trials. 2017. PMID: 28114954 Free PMC article. Clinical Trial.
Along with its chronic disease burden it creates high societal costs. Therapy consists of long-term use of medication and, if insufficient, endoscopic sinus surgery. ...
Along with its chronic disease burden it creates high societal costs. Therapy consists of long-term use of medication and, if insuffi …
Integrated care pathways for airway diseases (AIRWAYS-ICPs).
European Innovation Partnership on Active and Healthy Ageing, Action Plan B3; Mechanisms of the Development of Allergy, WP 10; Global Alliance against Chronic Respiratory Diseases; Bousquet J, Addis A, Adcock I, Agache I, Agusti A, Alonso A, Annesi-Maesano I, Anto JM, Bachert C, Baena-Cagnani CE, Bai C, Baigenzhin A, Barbara C, Barnes PJ, Bateman ED, Beck L, Bedbrook A, Bel EH, Benezet O, Bennoor KS, Benson M, Bernabeu-Wittel M, Bewick M, Bindslev-Jensen C, Blain H, Blasi F, Bonini M, Bonini S, Boulet LP, Bourdin A, Bourret R, Bousquet PJ, Brightling CE, Briggs A, Brozek J, Buhl R, Bush A, Caimmi D, Calderon M, Calverley P, Camargos PA, Camuzat T, Canonica GW, Carlsen KH, Casale TB, Cazzola M, Cepeda Sarabia AM, Cesario A, Chen YZ, Chkhartishvili E, Chavannes NH, Chiron R, Chuchalin A, Chung KF, Cox L, Crooks G, Crooks MG, Cruz AA, Custovic A, Dahl R, Dahlen SE, De Blay F, Dedeu T, Deleanu D, Demoly P, Devillier P, Didier A, Dinh-Xuan AT, Djukanovic R, Dokic D, Douagui H, Dubakiene R, Eglin S, Elliot F, Emuzyte R, Fabbri L, Fink Wagner A, Fletcher M, Fokkens WJ, Fonseca J, Franco A, Frith P, Furber A, Gaga M, Garcés J, Garcia-Aymerich J, Gamkrelidze A, Gonzales-Diaz S, Gouz… See abstract for full author list ➔ European Innovation Partnership on Active and Healthy Ageing, Action Plan B3, et al. Among authors: fokkens wj. Eur Respir J. 2014 Aug;44(2):304-23. doi: 10.1183/09031936.00014614. Epub 2014 Jun 12. Eur Respir J. 2014. PMID: 24925919 Free article.
AIRWAYS-ICPs has strategic relevance to the European Union Health Strategy and will add value to existing public health knowledge by: 1) proposing a common framework of care pathways for chronic respiratory diseases, which will facilitate comparability and trans-national initiati …
AIRWAYS-ICPs has strategic relevance to the European Union Health Strategy and will add value to existing public health knowledge by: 1) pro …
Long-term results of functional endoscopic sinus surgery in children with chronic rhinosinusitis with nasal polyps.
Cornet ME, Georgalas C, Reinartz SM, Fokkens WJ. Cornet ME, et al. Among authors: fokkens wj. Rhinology. 2013 Dec;51(4):328-34. doi: 10.4193/Rhino13.079. Rhinology. 2013. PMID: 24260765
Functional endoscopic sinus surgery (FESS) has proven to be an effective treatment, but it is still unclear what long-term outcomes are in children with CRSwNP. The objective of this study was to assess long-term results of FESS in children with CRSwNP. ...In childr …
Functional endoscopic sinus surgery (FESS) has proven to be an effective treatment, but it is still unclear what long-term outcomes a …
23 results