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Cutting edge: activation of virus-specific CD4 T cells throughout γ-herpesvirus latency.
Freeman ML, Burkum CE, Lanzer KG, Jensen MK, Ahmed M, Yager EJ, Flaño E, Winslow GM, Woodland DL, Blackman MA. Freeman ML, et al. Among authors: flano e. J Immunol. 2011 Dec 15;187(12):6180-4. doi: 10.4049/jimmunol.1102745. Epub 2011 Nov 11. J Immunol. 2011. PMID: 22079983 Free PMC article.
We previously identified a murine MHC class II-restricted epitope in gamma-herpesvirus-68 gp150 (gp150(67-83)I-A(b)) that elicits CD4 T cells that are maintained throughout long-term infection. However, it is unknown whether naive cells can be recruited into the antiviral …
We previously identified a murine MHC class II-restricted epitope in gamma-herpesvirus-68 gp150 (gp150(67-83)I-A(b)) that elicits CD4 T cell …
KLRG1+NKG2A+ CD8 T cells mediate protection and participate in memory responses during γ-herpesvirus infection.
Cush SS, Flaño E. Cush SS, et al. Among authors: flano e. J Immunol. 2011 Apr 1;186(7):4051-8. doi: 10.4049/jimmunol.1003122. Epub 2011 Feb 23. J Immunol. 2011. PMID: 21346231 Free PMC article.
Nevertheless, gammaHV68-specific NKG2A(+)KLRG1(+) CD8 T cells express IL-7 and IL-15 receptors, can survive long-term without cognate Ag, and subsequently mount a protective response during antigenic recall. ...
Nevertheless, gammaHV68-specific NKG2A(+)KLRG1(+) CD8 T cells express IL-7 and IL-15 receptors, can survive long-term without cognate …
Dendritic cells loaded with tumor B cells elicit broad immunity against murine gammaherpesvirus 68 but fail to prevent long-term latency.
Weslow-Schmidt J, Ye F, Cush SS, Stuller KA, Blackman MA, Flaño E. Weslow-Schmidt J, et al. Among authors: flano e. J Virol. 2010 Sep;84(17):8975-9. doi: 10.1128/JVI.00571-10. Epub 2010 Jun 30. J Virol. 2010. PMID: 20592077 Free PMC article.
Dendritic cell vaccination prevents the enlargement of lymph nodes and severely limits acute infection and early latency but does not prevent gammaHV68 from establishing long-term latency. Our findings support the concept that attenuated viruses may be the best vaccine opt …
Dendritic cell vaccination prevents the enlargement of lymph nodes and severely limits acute infection and early latency but does not preven …
Protective antigen-independent CD8 T cell memory is maintained during {gamma}-herpesvirus persistence.
Cush SS, Flaño E. Cush SS, et al. Among authors: flano e. J Immunol. 2009 Apr 1;182(7):3995-4004. doi: 10.4049/jimmunol.0803625. J Immunol. 2009. PMID: 19299697 Free PMC article.
Importantly, the Ag-independent CD8 T cell memory that is maintained during gamma-herpesvirus persistence has the capacity to survive long-term under homeostatic conditions and to mount a protective recall response to a secondary encounter with the pathogen. These data hig …
Importantly, the Ag-independent CD8 T cell memory that is maintained during gamma-herpesvirus persistence has the capacity to survive long- …
Memory generation and maintenance of CD8+ T cell function during viral persistence.
Cush SS, Anderson KM, Ravneberg DH, Weslow-Schmidt JL, Flaño E. Cush SS, et al. Among authors: flano e. J Immunol. 2007 Jul 1;179(1):141-53. doi: 10.4049/jimmunol.179.1.141. J Immunol. 2007. PMID: 17579032 Free PMC article.
During the primary immune response, we show generation of CD8+ memory T cell precursors expressing lymphoid homing molecules (CCR7, L-selectin) and homeostatic cytokine receptors (IL-7alpha, IL-2/IL-15beta). During long-term persistent infection, central-memory cells const …
During the primary immune response, we show generation of CD8+ memory T cell precursors expressing lymphoid homing molecules (CCR7, L-select …
Infection of dendritic cells by a gamma2-herpesvirus induces functional modulation.
Flaño E, Kayhan B, Woodland DL, Blackman MA. Flaño E, et al. J Immunol. 2005 Sep 1;175(5):3225-34. doi: 10.4049/jimmunol.175.5.3225. J Immunol. 2005. PMID: 16116213 Free PMC article.
Analysis of infected mice shows elevated levels of IL-10 expression in DCs and that lack of endogenous IL-10 is associated with decreased gammaHV68 long-term latency. Taken together, these observations indicate that gamma2-herpesvirus infection of DCs is a mechanism of vir …
Analysis of infected mice shows elevated levels of IL-10 expression in DCs and that lack of endogenous IL-10 is associated with decreased ga …
Early establishment of gamma-herpesvirus latency: implications for immune control.
Flaño E, Jia Q, Moore J, Woodland DL, Sun R, Blackman MA. Flaño E, et al. J Immunol. 2005 Apr 15;174(8):4972-8. doi: 10.4049/jimmunol.174.8.4972. J Immunol. 2005. PMID: 15814726 Free PMC article.
The virus exploits the life cycle of the B cell and latency is maintained long term in resting memory B cells. In this study, using a murine gamma-herpesvirus model, we demonstrate an early dominance of latent virus at the site of infection, with lung B cells harboring vir …
The virus exploits the life cycle of the B cell and latency is maintained long term in resting memory B cells. In this study, using a …
T cell reactivity during infectious mononucleosis and persistent gammaherpesvirus infection in mice.
Flaño E, Hardy CL, Kim IJ, Frankling C, Coppola MA, Nguyen P, Woodland DL, Blackman MA. Flaño E, et al. J Immunol. 2004 Mar 1;172(5):3078-85. doi: 10.4049/jimmunol.172.5.3078. J Immunol. 2004. PMID: 14978113
In the current studies, we show that elevated Vbeta4(+)CD8(+) T cell levels are sustained long-term in persistently infected mice, apparently a consequence of continued ligand expression. ...
In the current studies, we show that elevated Vbeta4(+)CD8(+) T cell levels are sustained long-term in persistently infected mice, ap …
Differential gamma-herpesvirus distribution in distinct anatomical locations and cell subsets during persistent infection in mice.
Flaño E, Kim IJ, Moore J, Woodland DL, Blackman MA. Flaño E, et al. J Immunol. 2003 Apr 1;170(7):3828-34. doi: 10.4049/jimmunol.170.7.3828. J Immunol. 2003. PMID: 12646650
Importantly, we demonstrate that although latency in the lung is established in a variety of cell subsets, long-term latency in the lung is only maintained in B cells. In contrast, splenic latency is maintained in macrophages and dendritic cells, as well as in B cells. ... …
Importantly, we demonstrate that although latency in the lung is established in a variety of cell subsets, long-term latency in the l …
15 results