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Infants Admitted to US Intensive Care Units for RSV Infection During the 2022 Seasonal Peak.
Halasa N, Zambrano LD, Amarin JZ, Stewart LS, Newhams MM, Levy ER, Shein SL, Carroll CL, Fitzgerald JC, Michaels MG, Bline K, Cullimore ML, Loftis L, Montgomery VL, Jeyapalan AS, Pannaraj PS, Schwarz AJ, Cvijanovich NZ, Zinter MS, Maddux AB, Bembea MM, Irby K, Zerr DM, Kuebler JD, Babbitt CJ, Gaspers MG, Nofziger RA, Kong M, Coates BM, Schuster JE, Gertz SJ, Mack EH, White BR, Harvey H, Hobbs CV, Dapul H, Butler AD, Bradford TT, Rowan CM, Wellnitz K, Staat MA, Aguiar CL, Hymes SR, Randolph AG, Campbell AP; RSV-PIC Investigators. Halasa N, et al. Among authors: fitzgerald jc. JAMA Netw Open. 2023 Aug 1;6(8):e2328950. doi: 10.1001/jamanetworkopen.2023.28950. JAMA Netw Open. 2023. PMID: 37581884 Free PMC article.
CONCLUSIONS AND RELEVANCE: In this cross-sectional study, most US infants who required intensive care for RSV LRTIs were young, healthy, and born at term. These findings highlight the need for RSV preventive interventions targeting all infants to reduce the burden of sever …
CONCLUSIONS AND RELEVANCE: In this cross-sectional study, most US infants who required intensive care for RSV LRTIs were young, healthy, and …
Variation in Early Anakinra Use and Short-Term Outcomes in Multisystem Inflammatory Syndrome in Children.
Chang JC, Young CC, Muscal E, Sexson Tejtel SK, Newhams MM, Kucukak S, Crandall H, Maddux AB, Rowan CM, Halasa NB, Harvey HA, Hobbs CV, Hall MW, Kong M, Aguiar CL, Schuster JE, Fitzgerald JC, Singh AR, Wellnitz K, Nofziger RA, Cvijanovich NZ, Mack EH, Schwarz AJ, Heidemann SM, Newburger JW, Zambrano LD, Campbell AP, Patel MM, Randolph AG, Son MBF; Overcoming COVID-19 Investigators. Chang JC, et al. Among authors: fitzgerald jc. Arthritis Rheumatol. 2023 Aug;75(8):1466-1476. doi: 10.1002/art.42495. Epub 2023 May 16. Arthritis Rheumatol. 2023. PMID: 36908050
CONCLUSION: We identified substantial variation in initial anakinra use in a real-world population of children with MIS-C, but no average short-term improvement in cardiovascular outcomes associated with early addition of anakinra to IVIG and/or glucocorticoids compared to …
CONCLUSION: We identified substantial variation in initial anakinra use in a real-world population of children with MIS-C, but no average sh …
Refining the Pediatric Multiple Organ Dysfunction Syndrome.
Weiss SL, Carcillo JA, Leclerc F, Leteurtre S, Schlapbach LJ, Tissieres P, Wynn JL, Lacroix J; Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Collaborative. Weiss SL, et al. Pediatrics. 2022 Jan 1;149(1 Suppl 1):S13-S22. doi: 10.1542/peds.2021-052888C. Pediatrics. 2022. PMID: 34970671 Free PMC article.
Since its introduction into the medical literature in the 1970s, the term multiple organ dysfunction syndrome (or some variant) has been applied broadly to any patient with >1 concurrent organ dysfunction. However, the epidemiology, mechanisms, time course, and outcomes …
Since its introduction into the medical literature in the 1970s, the term multiple organ dysfunction syndrome (or some variant) has b …
Frequency, Characteristics and Complications of COVID-19 in Hospitalized Infants.
Hobbs CV, Woodworth K, Young CC, Jackson AM, Newhams MM, Dapul H, Maamari M, Hall MW, Maddux AB, Singh AR, Schuster JE, Rowan CM, Fitzgerald JC, Irby K, Kong M, Mack EH, Staat MA, Cvijanovich NZ, Bembea MM, Coates BM, Halasa NB, Walker TC, McLaughlin GE, Babbitt CJ, Nofziger RA, Loftis LL, Bradford TT, Campbell AP, Patel MM, Randolph AG; for the Overcoming COVID-19 Investigators. Hobbs CV, et al. Among authors: fitzgerald jc. Pediatr Infect Dis J. 2022 Mar 1;41(3):e81-e86. doi: 10.1097/INF.0000000000003435. Pediatr Infect Dis J. 2022. PMID: 34955519 Free PMC article.
Although most infants hospitalized with COVID-19 did not suffer significant complications, longer term outcomes remain unclear. Notably, 75% of infants with severe disease were <6 months of age in this cohort study period, which predated maternal COVID-19 vaccination, u …
Although most infants hospitalized with COVID-19 did not suffer significant complications, longer term outcomes remain unclear. Notab …
Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome.
LaRovere KL, Riggs BJ, Poussaint TY, Young CC, Newhams MM, Maamari M, Walker TC, Singh AR, Dapul H, Hobbs CV, McLaughlin GE, Son MBF, Maddux AB, Clouser KN, Rowan CM, McGuire JK, Fitzgerald JC, Gertz SJ, Shein SL, Munoz AC, Thomas NJ, Irby K, Levy ER, Staat MA, Tenforde MW, Feldstein LR, Halasa NB, Giuliano JS Jr, Hall MW, Kong M, Carroll CL, Schuster JE, Doymaz S, Loftis LL, Tarquinio KM, Babbitt CJ, Nofziger RA, Kleinman LC, Keenaghan MA, Cvijanovich NZ, Spinella PC, Hume JR, Wellnitz K, Mack EH, Michelson KN, Flori HR, Patel MM, Randolph AG; Overcoming COVID-19 Investigators. LaRovere KL, et al. Among authors: fitzgerald jc. JAMA Neurol. 2021 May 1;78(5):536-547. doi: 10.1001/jamaneurol.2021.0504. JAMA Neurol. 2021. PMID: 33666649 Free PMC article.
A range of life-threatening and fatal neurologic conditions associated with COVID-19 infrequently occurred. Effects on long-term neurodevelopmental outcomes are unknown....
A range of life-threatening and fatal neurologic conditions associated with COVID-19 infrequently occurred. Effects on long-term neur …
Evidence of thrombotic microangiopathy in children with SARS-CoV-2 across the spectrum of clinical presentations.
Diorio C, McNerney KO, Lambert M, Paessler M, Anderson EM, Henrickson SE, Chase J, Liebling EJ, Burudpakdee C, Lee JH, Balamuth FB, Blatz AM, Chiotos K, Fitzgerald JC, Giglia TM, Gollomp K, Odom John AR, Jasen C, Leng T, Petrosa W, Vella LA, Witmer C, Sullivan KE, Laskin BL, Hensley SE, Bassiri H, Behrens EM, Teachey DT. Diorio C, et al. Among authors: fitzgerald jc. Blood Adv. 2020 Dec 8;4(23):6051-6063. doi: 10.1182/bloodadvances.2020003471. Blood Adv. 2020. PMID: 33290544 Free PMC article.
Future studies are needed to determine if hospitalized children with SARS-CoV-2 should be screened for TMA, if TMA-directed management is helpful, and if there are any short- or long-term clinical consequences of complement activation and endothelial damage in children wit …
Future studies are needed to determine if hospitalized children with SARS-CoV-2 should be screened for TMA, if TMA-directed management is he …
Severe Acute Kidney Injury Is Associated With Increased Risk of Death and New Morbidity After Pediatric Septic Shock.
Starr MC, Banks R, Reeder RW, Fitzgerald JC, Pollack MM, Meert KL, McQuillen PS, Mourani PM, Chima RS, Sorenson S, Varni JW, Hingorani S, Zimmerman JJ; Life After Pediatric Sepsis Evaluation (LAPSE) Investigators. Starr MC, et al. Among authors: fitzgerald jc. Pediatr Crit Care Med. 2020 Sep;21(9):e686-e695. doi: 10.1097/PCC.0000000000002418. Pediatr Crit Care Med. 2020. PMID: 32569242 Free PMC article.
Our primary outcome was a composite of mortality or new functional morbidity at day 28 of hospitalization or discharge. We also assessed poor long-term outcome, defined as mortality or a persistent, serious deterioration in health-related quality of life at 3 months. ...
Our primary outcome was a composite of mortality or new functional morbidity at day 28 of hospitalization or discharge. We also assessed poo …
Derivation of a metabolic signature associated with bacterial meningitis in infants.
Gordon SM, Srinivasan L, Taylor DM, Master SR, Tremoglie MA, Hankeova A, Flannery DD, Abbasi S, Fitzgerald JC, Harris MC. Gordon SM, et al. Among authors: fitzgerald jc. Pediatr Res. 2020 Aug;88(2):184-191. doi: 10.1038/s41390-020-0816-7. Epub 2020 Mar 2. Pediatr Res. 2020. PMID: 32120377 Free PMC article.
METHODS: In a nested case-control study, we examined >400 metabolites in CSF of uninfected infants and infants with culture-confirmed BM using gas and liquid chromatography mass spectrometry. Preterm and full-term infants in a Level III or IV Neonatal Intensive Care Uni …
METHODS: In a nested case-control study, we examined >400 metabolites in CSF of uninfected infants and infants with culture-confirmed BM …
Association of Delayed Antimicrobial Therapy with One-Year Mortality in Pediatric Sepsis.
Han M, Fitzgerald JC, Balamuth F, Keele L, Alpern ER, Lavelle J, Chilutti M, Grundmeier RW, Nadkarni VM, Thomas NJ, Weiss SL. Han M, et al. Among authors: fitzgerald jc. Shock. 2017 Jul;48(1):29-35. doi: 10.1097/SHK.0000000000000833. Shock. 2017. PMID: 28114166 Free PMC article.
OBJECTIVE: Delayed antimicrobial therapy in sepsis is associated with increased hospital mortality, but the impact of antimicrobial timing on long-term outcomes is unknown. We tested the hypothesis that hourly delays to antimicrobial therapy are associated with 1-year mort …
OBJECTIVE: Delayed antimicrobial therapy in sepsis is associated with increased hospital mortality, but the impact of antimicrobial timing o …
2016 Update for the Rogers' Textbook of Pediatric Intensive Care: Recognition and Initial Management of Shock.
Fitzgerald JC, Weiss SL, Kissoon N. Fitzgerald JC, et al. Pediatr Crit Care Med. 2016 Nov;17(11):1073-1079. doi: 10.1097/PCC.0000000000000942. Pediatr Crit Care Med. 2016. PMID: 27749512 Free PMC article. Review.
National Library of Medicine PubMed (www.ncbi.nlm.nih.gov/pubmed) was searched for combination of the term "pediatric" and the following terms: "sepsis, septic shock, shock, antibiotics, extracorporeal membrane oxygenation, and steroid." ...
National Library of Medicine PubMed (www.ncbi.nlm.nih.gov/pubmed) was searched for combination of the term "pediatric" and the follow …
12 results