Treg-inducing microparticles promote donor-specific tolerance in experimental vascularized composite allotransplantation.
Fisher JD, Balmert SC, Zhang W, Schweizer R, Schnider JT, Komatsu C, Dong L, Erbas VE, Unadkat JV, Aral AM, Acharya AP, Kulahci Y, Turnquist HR, Thomson AW, Solari MG, Gorantla VS, Little SR.
Fisher JD, et al.
Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25784-25789. doi: 10.1073/pnas.1910701116. Epub 2019 Dec 2.
Proc Natl Acad Sci U S A. 2019.
PMID: 31792185
Free PMC article.
In a rat hindlimb VCA model, local administration of this Treg-inducing system, referred to as TRI-MP, prolonged allograft survival indefinitely without long-term systemic immunosuppression. TRI-MP treatment reduced expression of inflammatory mediators and enhanced express …
In a rat hindlimb VCA model, local administration of this Treg-inducing system, referred to as TRI-MP, prolonged allograft survival indefini …