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Lymphocyte Depleting and Modulating Therapies for Chronic Lung Allograft Dysfunction.
Bos S, Pradère P, Beeckmans H, Zajacova A, Vanaudenaerde BM, Fisher AJ, Vos R. Bos S, et al. Among authors: fisher aj. Pharmacol Rev. 2023 Nov;75(6):1200-1217. doi: 10.1124/pharmrev.123.000834. Epub 2023 Jun 9. Pharmacol Rev. 2023. PMID: 37295951 Review.
Chronic lung rejection, also called chronic lung allograft dysfunction (CLAD), remains the major hurdle limiting long-term survival after lung transplantation, and limited therapeutic options are available to slow the progressive decline in lung function. ...
Chronic lung rejection, also called chronic lung allograft dysfunction (CLAD), remains the major hurdle limiting long-term survival a …
Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle.
Bos S, Milross L, Filby AJ, Vos R, Fisher AJ. Bos S, et al. Among authors: fisher aj. Eur Respir Rev. 2022 Jul 27;31(165):220060. doi: 10.1183/16000617.0060-2022. Print 2022 Sep 30. Eur Respir Rev. 2022. PMID: 35896274 Free PMC article. Review.
However, chronic lung allograft dysfunction remains the leading obstacle to improved long-term outcomes. Traditionally, lung allograft rejection has been considered primarily as a manifestation of cellular immune responses. ...
However, chronic lung allograft dysfunction remains the leading obstacle to improved long-term outcomes. Traditionally, lung allograf …
Effector immune cells in chronic lung allograft dysfunction: A systematic review.
Bos S, Filby AJ, Vos R, Fisher AJ. Bos S, et al. Among authors: fisher aj. Immunology. 2022 May;166(1):17-37. doi: 10.1111/imm.13458. Epub 2022 Mar 1. Immunology. 2022. PMID: 35137398 Free PMC article. Review.
Chronic lung allograft dysfunction (CLAD) remains the major barrier to long-term survival after lung transplantation and improved insight into its underlying immunological mechanisms is critical to better understand the disease and to identify treatment targets. ...
Chronic lung allograft dysfunction (CLAD) remains the major barrier to long-term survival after lung transplantation and improved ins …
Pharmacological characterisation of GSK3335103, an oral αvβ6 integrin small molecule RGD-mimetic inhibitor for the treatment of fibrotic disease.
Wilkinson AL, John AE, Barrett JW, Gower E, Morrison VS, Man Y, Pun KT, Roper JA, Luckett JC, Borthwick LA, Barksby BS, Burgoyne RA, Barnes R, Fisher AJ, Procopiou PA, Hatley RJD, Barrett TN, Marshall RP, Macdonald SJF, Jenkins RG, Slack RJ. Wilkinson AL, et al. Among authors: fisher aj. Eur J Pharmacol. 2021 Dec 15;913:174618. doi: 10.1016/j.ejphar.2021.174618. Epub 2021 Nov 8. Eur J Pharmacol. 2021. PMID: 34762934
Fibrosis is the formation of scar tissue due to injury or long-term inflammation and is a leading cause of morbidity and mortality. ...
Fibrosis is the formation of scar tissue due to injury or long-term inflammation and is a leading cause of morbidity and mortality. . …
Idiopathic pulmonary arterial hypertension and co-existing lung disease: is this a new phenotype?
Peacock AJ, Ling Y, Johnson MK, Kiely DG, Condliffe R, Elliot CA, Gibbs JSR, Howard LS, Pepke-Zaba J, Sheares KKK, Corris PA, Fisher AJ, Lordan JL, Gaine S, Coghlan JG, Wort SJ, Gatzoulis MA. Peacock AJ, et al. Among authors: fisher aj. Pulm Circ. 2020 Mar 30;10(1):2045894020914851. doi: 10.1177/2045894020914851. eCollection 2020 Jan-Mar. Pulm Circ. 2020. PMID: 32284847 Free PMC article.
This survival was significantly worse in 'IPAH (lung disease) ' even after adjusting for age, gender, smoking history, comorbidities and haemodynamics. 'IPAH (lung disease) ' patients had similar short-term improvement in six-minute walk distance with anti-pulmonary arteri …
This survival was significantly worse in 'IPAH (lung disease) ' even after adjusting for age, gender, smoking history, comorbidities and hae …
Long-term effect of azithromycin in bronchiolitis obliterans syndrome.
Gan CT, Ward C, Meachery G, Lordan JL, Fisher AJ, Corris PA. Gan CT, et al. Among authors: fisher aj. BMJ Open Respir Res. 2019 Oct 15;6(1):e000465. doi: 10.1136/bmjresp-2019-000465. eCollection 2019. BMJ Open Respir Res. 2019. PMID: 31673366 Free PMC article. Clinical Trial.
Survival of patients with early BOS was similar to late-onset BOS (log-rank test p=0.74). DISCUSSION: Long-term treatment with azithromycin slows down the progression of BOS, although the effect of TLI may affect the observed attenuation of FEV(1) decline. BOS progression …
Survival of patients with early BOS was similar to late-onset BOS (log-rank test p=0.74). DISCUSSION: Long-term treatment with azithr …
Pathophysiology and classification of primary graft dysfunction after lung transplantation.
Morrison MI, Pither TL, Fisher AJ. Morrison MI, et al. Among authors: fisher aj. J Thorac Dis. 2017 Oct;9(10):4084-4097. doi: 10.21037/jtd.2017.09.09. J Thorac Dis. 2017. PMID: 29268419 Free PMC article. Review.
The term primary graft dysfunction (PGD) incorporates a continuum of disease severity from moderate to severe acute lung injury (ALI) within 72 h of lung transplantation. ...
The term primary graft dysfunction (PGD) incorporates a continuum of disease severity from moderate to severe acute lung injury (ALI) …
Survival in portopulmonary hypertension: Outcomes of the United Kingdom National Pulmonary Arterial Hypertension Registry.
Sithamparanathan S, Nair A, Thirugnanasothy L, Coghlan JG, Condliffe R, Dimopoulos K, Elliot CA, Fisher AJ, Gaine S, Gibbs JSR, Gatzoulis MA, E Handler C, Howard LS, Johnson M, Kiely DG, Lordan JL, Peacock AJ, Pepke-Zaba J, Schreiber BE, Sheares KKK, Wort SJ, Corris PA; National Pulmonary Hypertension Service Research Collaboration of the United Kingdom and Ireland. Sithamparanathan S, et al. Among authors: fisher aj. J Heart Lung Transplant. 2017 Jul;36(7):770-779. doi: 10.1016/j.healun.2016.12.014. Epub 2016 Dec 31. J Heart Lung Transplant. 2017. PMID: 28190786
BACKGROUND: Portopulmonary hypertension (PoPH) is a rare condition associated with poor survival, and the effect of modern therapies that target pulmonary arterial hypertension (PAH) on long-term outcome is unknown. This study investigated the baseline characteristics and …
BACKGROUND: Portopulmonary hypertension (PoPH) is a rare condition associated with poor survival, and the effect of modern therapies that ta …
An association of particulate air pollution and traffic exposure with mortality after lung transplantation in Europe.
Ruttens D, Verleden SE, Bijnens EM, Winckelmans E, Gottlieb J, Warnecke G, Meloni F, Morosini M, Van Der Bij W, Verschuuren EA, Sommerwerck U, Weinreich G, Kamler M, Roman A, Gomez-Olles S, Berastegui C, Benden C, Holm AM, Iversen M, Schultz HH, Luijk B, Oudijk EJ, Kwakkel-van Erp JM, Jaksch P, Klepetko W, Kneidinger N, Neurohr C, Corris P, Fisher AJ, Lordan J, Meachery G, Piloni D, Vandermeulen E, Bellon H, Hoffmann B, Vienneau D, Hoek G, de Hoogh K, Nemery B, Verleden GM, Vos R, Nawrot TS, Vanaudenaerde BM. Ruttens D, et al. Among authors: fisher aj. Eur Respir J. 2017 Jan 18;49(1):1600484. doi: 10.1183/13993003.00484-2016. Print 2017 Jan. Eur Respir J. 2017. PMID: 27836956 Free article.
Sensitivity analyses for various possible confounders confirmed the robustness of these associations.Long-term residential air pollution and traffic exposure were associated with CLAD and survival after lung transplantation, but only in patients not taking macrolides....
Sensitivity analyses for various possible confounders confirmed the robustness of these associations.Long-term residential air pollut …
High-intensity interval training, but not continuous training, reverses right ventricular hypertrophy and dysfunction in a rat model of pulmonary hypertension.
Brown MB, Neves E, Long G, Graber J, Gladish B, Wiseman A, Owens M, Fisher AJ, Presson RG, Petrache I, Kline J, Lahm T. Brown MB, et al. Among authors: fisher aj. Am J Physiol Regul Integr Comp Physiol. 2017 Feb 1;312(2):R197-R210. doi: 10.1152/ajpregu.00358.2016. Epub 2016 Oct 26. Am J Physiol Regul Integr Comp Physiol. 2017. PMID: 27784688 Free PMC article.
To characterize acute hemodynamic responses to the two approaches, novel recordings of simultaneous pulmonary and systemic pressures during running were obtained at pre- and 2, 4, 6, and 8 wk post-MCT using long-term implantable telemetry. MCT-induced decrement in maximal …
To characterize acute hemodynamic responses to the two approaches, novel recordings of simultaneous pulmonary and systemic pressures during …
27 results